INT50724

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.17
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
substantia nigra 3
ventral 1
Nr4a2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 5 99.20 Very High Very High Very High
Substantia nigra 2 99.20 Very High Very High Very High
antinociception 5 99.18 Very High Very High Very High
Ventral tegmentum 2 98.36 Very High Very High Very High
tail-flick 3 90.44 High High
Nucleus accumbens 4 89.68 High High
antagonist 4 87.88 High High
Dopamine 6 86.28 High High
Kappa opioid receptor 3 75.52 Quite High
Spinal cord 1 63.36 Quite High
Disease Link Frequency Relevance Heat
Psychosis 2 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are consistent with the previous study in mice [Tseng LF and Collins KA (1992) Eur J Pharmacol 214: 59-65] that the antinociception induced by beta-endorphin given i.t. is mediated by the stimulation of mu- and kappa-, but not delta- and epsilon-opioid receptors.
Positive_regulation (mediated) of Positive_regulation (stimulation) of not associated with antinociception and opioid receptor
1) Confidence 0.49 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7643909 Disease Relevance 0 Pain Relevance 0.98
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of Positive_regulation (increased) of Nurr1 in substantia nigra associated with ventral tegmentum and substantia nigra
2) Confidence 0.39 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of in ventral Positive_regulation (increased) of Nurr1 in substantia nigra associated with ventral tegmentum and substantia nigra
3) Confidence 0.13 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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