INT50740

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1995
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 8.30
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPG21) endosome (SPG21) cell death (SPG21)
Golgi apparatus (SPG21) nucleus (SPG21) cytoplasm (SPG21)
Anatomy Link Frequency
mast cell 16
synovial fluid 1
urine 1
SPG21 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 4 99.64 Very High Very High Very High
interstitial cystitis 6 98.20 Very High Very High Very High
spastic colon 1 97.48 Very High Very High Very High
cytokine 3 96.56 Very High Very High Very High
chemokine 3 96.20 Very High Very High Very High
Opioid 2 95.76 Very High Very High Very High
Neurotransmitter 2 94.28 High High
Bile 1 93.58 High High
Pain 4 90.88 High High
opiate 2 87.72 High High
Disease Link Frequency Relevance Heat
Gastroenteritis 1 99.88 Very High Very High Very High
Urticaria 13 99.74 Very High Very High Very High
Cancer 6 99.58 Very High Very High Very High
Rhinitis 1 99.56 Very High Very High Very High
Parasitic Infection 3 98.56 Very High Very High Very High
Hypersensitivity 11 98.28 Very High Very High Very High
Interstitial Cystitis 6 98.20 Very High Very High Very High
Anaphylaxis 21 97.96 Very High Very High Very High
Functional Bowel Disorder 1 97.48 Very High Very High Very High
Pressure Volume 2 Under Development 6 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal urinary levels of LTE4 and serum mast cell tryptase were increased in aspirin-sensitive compared with aspirin-tolerant patients.
Positive_regulation (increased) of mast in mast cell
1) Confidence 0.67 Published 2003 Journal Arch Dermatol Section Body Doc Link 14676074 Disease Relevance 0 Pain Relevance 0
Mast cell tryptase concentrations were increased in 158 patients, equivocal in 10 and not increased in 182.
Neg (not) Positive_regulation (increased) of Mast in Mast cell
2) Confidence 0.67 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.16 Pain Relevance 0
Screening for mast cell tryptase and serum IgE antibodies in 18 patients with anaphylactic shock during general anaesthesia.
Positive_regulation (Screening) of mast in mast cell associated with anaphylaxis
3) Confidence 0.49 Published 2003 Journal Acta Anaesthesiol Scand Section Title Doc Link 14616317 Disease Relevance 0.28 Pain Relevance 0.08
MATERIALS AND METHODS: We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, FcepsilonRIalpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera.
Positive_regulation (augmented) of mast in mast cell
4) Confidence 0.49 Published 2006 Journal BJU Int. Section Body Doc Link 16469037 Disease Relevance 0.17 Pain Relevance 0
MATERIALS AND METHODS: We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, FcepsilonRIalpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera.
Positive_regulation (up-regulation) of mast in mast cell
5) Confidence 0.49 Published 2006 Journal BJU Int. Section Body Doc Link 16469037 Disease Relevance 0.19 Pain Relevance 0
CONCLUSION: This study revealed that mast cell mediator tryptase concentrations increase after intravenous heroin injection in chronic opioid users, but not after heroin inhalation.
Positive_regulation (increase) of mast in mast cell
6) Confidence 0.49 Published 2006 Journal Drug Alcohol Depend Section Body Doc Link 16765536 Disease Relevance 0 Pain Relevance 0
Increased concentrations of mast cell tryptase are a highly sensitive indicator of anaphylactic reactions during anaesthesia.
Positive_regulation (Increased) of mast in mast cell associated with anaphylaxis
7) Confidence 0.49 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.19 Pain Relevance 0
Seven of 143 patients whose mast cell tryptase concentrations were not increased at appropriate sampling times had positive tests for IgE antibodies, and in 33 of 158 patients with increased mast cell tryptase concentrations no IgE antibodies were detected.
Positive_regulation (increased) of mast in mast cell
8) Confidence 0.49 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
We conclude that increased mast cell tryptase concentrations are a valuable indicator of an anaphylactic reaction during anaesthesia.
Positive_regulation (increased) of mast in mast cell associated with anaphylaxis
9) Confidence 0.49 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
Positive_regulation (immunostained) of mast in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
10) Confidence 0.49 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.41 Pain Relevance 0.24
We tested the hypothesis that the flare was a Type-1 hypersensitivity reaction as manifested by the presence of Synvisc antibodies in the synovial fluid and serum and by an increase in the concentration of the mast-cell enzyme tryptase in the synovial fluid.
Positive_regulation (increase) of mast in synovial fluid associated with hypersensitivity
11) Confidence 0.49 Published 2006 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 16394759 Disease Relevance 0.27 Pain Relevance 0.09
Nonimmunological urticarias result from mast cell activation through membrane receptors involved in innate immunity (e.g., complement, Toll-like, cytokine/chemokine, opioid) or by direct toxicity of xenobiotics (haptens, drugs).
Positive_regulation (activation) of mast in mast cell associated with urticaria, chemokine, toxicity, opioid and cytokine
12) Confidence 0.45 Published 2006 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 16461989 Disease Relevance 1.31 Pain Relevance 0.19
Elevated mast cell tryptase in the urine of patients with interstitial cystitis.
Positive_regulation (Elevated) of mast in urine associated with interstitial cystitis
13) Confidence 0.45 Published 1995 Journal Br J Urol Section Title Doc Link 7648070 Disease Relevance 0.19 Pain Relevance 0.28
Adenosine and inosine both activate mast cell A(3) receptors, liberating vasoactive substances and increasing vascular permeability.
Positive_regulation (activate) of mast in mast cell associated with adenocard
14) Confidence 0.45 Published 2002 Journal Toxicon Section Abstract Doc Link 11738231 Disease Relevance 0.35 Pain Relevance 0.21
There was a significant difference in the incidence of positive intradermal tests, radioimmunoassay tests and evidence of an IgE-mediated reaction in patients whose mast cell tryptase concentrations were increased.
Positive_regulation (increased) of mast in mast cell
15) Confidence 0.45 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
Seven of 143 patients whose mast cell tryptase concentrations were not increased at appropriate sampling times had positive tests for IgE antibodies, and in 33 of 158 patients with increased mast cell tryptase concentrations no IgE antibodies were detected.
Neg (not) Positive_regulation (increased) of mast in mast cell
16) Confidence 0.45 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
The mast cell tryptase was also significantly elevated at 76 microg/L, (Normal 2-14 microg/L).
Positive_regulation (elevated) of mast in mast cell
17) Confidence 0.45 Published 2009 Journal Am J Forensic Med Pathol Section Abstract Doc Link 19465816 Disease Relevance 0.95 Pain Relevance 0.48
Immunohistologic studies on paraffin sections demonstrated that the majority of the tumor cells were strongly positive for CD45RB, CD68, and mast cell tryptase.
Positive_regulation (positive) of mast in mast cell associated with cancer
18) Confidence 0.21 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430280 Disease Relevance 0.98 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox