INT50743

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.99
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc2) nuclear envelope (Trpc2) plasma membrane (Trpc2)
nucleus (Trpc2) transmembrane transport (Trpc2)
Anatomy Link Frequency
vomeronasal organ 1
hairs 1
skin 1
Trpc2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 6 98.66 Very High Very High Very High
Opioid 9 94.96 High High
melanocortin 1 receptor 8 89.92 High High
Pain 10 89.84 High High
imagery 3 53.88 Quite High
Sciatica 4 50.00 Quite Low
nociceptor 3 25.00 Low Low
Glutamate 4 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
HCN1 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 6 94.92 High High
Targeted Disruption 5 88.88 High High
Cancer 4 82.84 Quite High
Aggression 2 79.76 Quite High
Skin Cancer 10 76.84 Quite High
Pain 7 75.00 Quite High
Nerve Root Compression 4 50.00 Quite Low
Metastasis 2 49.88 Quite Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation at the slaty locus (Slt(lt)) was found to have no effect on pheomelanogenesis, supporting a role of TRP2 only in eumelanogenesis.
Positive_regulation (role) of TRP2
1) Confidence 0.44 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0
In this study, we used congenic mice to eliminate genetic variability, and analyzed eumelanin and pheomelanin contents of hairs from mice mutant at one or more of the major pigment loci, i.e., the albino (C) locus that encodes tyrosinase, the slaty (Slt) locus that encodes tyrosinase-related protein 2 (TRP2 also known as dopachrome tautomerase, DCT), the brown (B) locus that encodes TRP1, the silver (Si) locus that encodes a melanosomal silver protein, the agouti (A) locus that encodes agouti signaling protein (ASP), the extension (E) locus that encodes melanocortin-1 receptor, and the mahogany (Mg) locus that encodes attractin.
Positive_regulation (encodes) of TRP2 in hairs associated with melanocortin 1 receptor
2) Confidence 0.44 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0.09
Phenotypes of chinchilla (c(ch)/c(ch)) mice that are wild type or mutant at the brown and/or slaty, loci indicate that functioning TRP2 and TRP1 are necessary, in addition to high levels of tyrosinase, for a full production of eumelanin.
Positive_regulation (necessary) of TRP2
3) Confidence 0.40 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0.08
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Neg (not) Positive_regulation (not) of TRP-2
4) Confidence 0.32 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.46 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of TRP-2
5) Confidence 0.32 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.47 Pain Relevance 0.14
By RT-PCR and western blot, full thickness skin of pTT-treated mice showed increases in Trp-1, Trp-2 and tyrosinase mRNA and protein levels, compared with control mice.
Positive_regulation (increases) of Trp-2 in skin
6) Confidence 0.31 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17620094 Disease Relevance 0 Pain Relevance 0.07
The inhibitory effect of stimulation of Sm II was reduced after ventriculer microinjection of 20ul of naloxone (n = 9), while marked inhibition was shown at 0-2.5 minutes after stimulating Sm II in the saline control group (n = 9, P < 0.05).
Positive_regulation (stimulation) of Sm II associated with narcan
7) Confidence 0.24 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648693 Disease Relevance 0.26 Pain Relevance 0.42
The inhibitory effect of stimulation of Sm II was reduced after ventriculer microinjection of 20ul of naloxone (n = 9), while marked inhibition was shown at 0-2.5 minutes after stimulating Sm II in the saline control group (n = 9, P < 0.05).
Positive_regulation (stimulating) of Sm II associated with narcan
8) Confidence 0.24 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648693 Disease Relevance 0.24 Pain Relevance 0.44
A handful of putative V1R genes have been reported in the human genome, but humans appear to lack a functional vomeronasal organ, as well as a functional TRPC2 ion channel [39], which is required for the function of the vomeronasal organ in the mouse [40,41].
Positive_regulation (required) of TRPC2 in vomeronasal organ
9) Confidence 0.16 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0.33 Pain Relevance 0.03
There was a statistical difference at 0-2.5 minutes after stimulating Sm II between the two groups (P < 0.05).
Positive_regulation (stimulating) of Sm II
10) Confidence 0.14 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648693 Disease Relevance 0.23 Pain Relevance 0.45
Patients with sciatica who had the Trp2 allele were significantly more flexible (P < 0.05), according to the modified Schober measure.
Positive_regulation (had) of Trp2
11) Confidence 0.05 Published 2002 Journal Spine Section Body Doc Link 11805640 Disease Relevance 0 Pain Relevance 0
RESULTS: Six patients with sciatica and 11 family members had the Trp2 allele.
Positive_regulation (had) of Trp2
12) Confidence 0.05 Published 2002 Journal Spine Section Body Doc Link 11805640 Disease Relevance 0 Pain Relevance 0

General Comments

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