INT50765

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 10.22
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocyte 1
marginal zone 1
B cells 1
leaf 1
T cells 1
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 86 99.80 Very High Very High Very High
diclofenac 27 99.30 Very High Very High Very High
endometriosis 12 99.28 Very High Very High Very High
cINOD 8 98.24 Very High Very High Very High
anesthesia 8 93.68 High High
dexamethasone 12 93.04 High High
Freund adjuvant 12 92.64 High High
pain pelvic 4 87.76 High High
Inflammation 254 87.08 High High
alcohol 1 50.24 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 56 99.98 Very High Very High Very High
Eczema 119 99.96 Very High Very High Very High
Immunization 42 99.40 Very High Very High Very High
Hypersensitivity 280 99.36 Very High Very High Very High
Endometriosis (extended) 12 99.28 Very High Very High Very High
Rhinitis 21 99.02 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Disease 111 98.88 Very High Very High Very High
Asthma 104 98.82 Very High Very High Very High
Eosinophilia 45 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum-soluble CD23 concentration was significantly elevated in patients with endometriosis when compared with the controls (P < 0.0001).
Positive_regulation (elevated) of CD23 associated with endometriosis
1) Confidence 0.68 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650148 Disease Relevance 0.61 Pain Relevance 0.43
We conclude that the elevation of soluble CD23 in patients with endometriosis suggests that there is activation of B cells, which respond to danazol but not leuprolide acetate injection.
Positive_regulation (elevation) of CD23 in B cells associated with endometriosis
2) Confidence 0.45 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650148 Disease Relevance 0.64 Pain Relevance 0.39
CONCLUSION: Gastric acid suppression was found to be a causative mechanism in the induction of IgE-mediated diclofenac allergy.


Positive_regulation (induction) of IgE
3) Confidence 0.39 Published 2010 Journal Clin. Exp. Allergy Section Body Doc Link 19817752 Disease Relevance 0.05 Pain Relevance 0
Total serum IgE was significantly elevated following systemic sensitisation but was not increased by aerosol challenge.
Positive_regulation (elevated) of IgE
4) Confidence 0.19 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.08 Pain Relevance 0
Total serum IgE was significantly increased at day 21 (p < 0.001), 7 days after the second injection of OVA/Alum, compared to naïve mice (Fig. 6).
Positive_regulation (increased) of IgE
5) Confidence 0.19 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0
IgE was elevated by OVA sensitisation but not boosted by OVA aerosol challenge.


Neg (not) Positive_regulation (elevated) of IgE
6) Confidence 0.15 Published 2004 Journal Respir Res Section Abstract Doc Link PMC521690 Disease Relevance 0.33 Pain Relevance 0.03
There was no further increase in the total serum IgE in mice that were sensitised and subsequently challenged with OVA aerosols compared to those that were only systemically sensitised (p = 0.842).
Neg (no) Positive_regulation (increase) of IgE
7) Confidence 0.15 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.14 Pain Relevance 0.03
Total serum IgE was significantly elevated following systemic sensitisation but was not increased by aerosol challenge.
Neg (not) Positive_regulation (increased) of IgE
8) Confidence 0.13 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.08 Pain Relevance 0
Conclusion: the clear elevation of IL-4 and IgE could allow to conclude a possible Th2-like dominated allergic response in TDI-exposed BALB/c mouse model.
Positive_regulation (elevation) of IgE associated with hypersensitivity
9) Confidence 0.12 Published 2007 Journal Scand. J. Immunol. Section Abstract Doc Link 17257216 Disease Relevance 0.43 Pain Relevance 0.20
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of CD23 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
10) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.15 Pain Relevance 0
Data from birth cohort studies suggest that atopy (defined by family history, other allergic manifestations such as eczema, elevated IgE, or sensitization) is a major risk factor for the development of childhood asthma (Lowe et al. 2002; Martinez et al. 1995; Platts-Mills et al. 1997; Wahn et al. 1997).
Positive_regulation (elevated) of IgE associated with asthma, hypersensitivity and eczema
11) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 1.19 Pain Relevance 0
RESULTS: Scratching behaviour was almost completely prevented in Cap-NC mice raised for 84 days under conventional conditions, and the development of dermatitis and elevation of the serum IgE level were significantly suppressed.
Positive_regulation (elevation) of IgE
12) Confidence 0.06 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15327540 Disease Relevance 0.15 Pain Relevance 0
Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (induces) of IgE in T cells associated with diclofenac
13) Confidence 0.05 Published 2002 Journal Toxicol. Lett. Section Title Doc Link 11992736 Disease Relevance 0.55 Pain Relevance 0.56
However, in contrast to streptozotocin, diclofenac caused a selective dose-dependent increase in both IgG(1) and IgE AFCs.
Positive_regulation (increase) of IgE associated with diclofenac
14) Confidence 0.05 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.35
DNA vaccination with plasmid encoding Der p 5, one of the minor HDM allergens, was reported to prevent induction of specific IgE synthesis [11].
Positive_regulation (induction) of IgE
15) Confidence 0.05 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.80 Pain Relevance 0.06
Diseases such as allergic asthma, rhinitis, and atopic dermatitis are all characterized by elevated levels of serum IgE.
Positive_regulation (elevated) of IgE associated with asthma, rhinitis, eczema and disease
16) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.61 Pain Relevance 0.11
Th2 cytokine IL-4 and IgE production were significant increased 5 days after last challenge while IFN-gamma level was below the detection limit.
Positive_regulation (increased) of IgE associated with cytokine
17) Confidence 0.04 Published 2007 Journal Scand. J. Immunol. Section Abstract Doc Link 17257216 Disease Relevance 0.45 Pain Relevance 0.22
This was demonstrated by elevated serum OVA-specific IgE levels (1,187 ng/ml ± 435 ng/ml; Figure 4A) airway eosinophils (1,786 ± 406 × 103; Figure 4B), mononuclear cells (381 ± 54 × 103, data not shown), and lymphocyte subsets (Figure 4C).
Positive_regulation (elevated) of IgE in lymphocyte
18) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.70 Pain Relevance 0
Determining total IgE, HDM-specific IgE, and HDM-specific IgG
Positive_regulation (total) of IgE
19) Confidence 0.02 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.51 Pain Relevance 0.26
In rodent models, widely different particles have been shown to increase allergen-specific IgE levels both after inhalation, intratracheal, intranasal, intraperitoneal and subcutaneous exposure [7-12].
Positive_regulation (increase) of IgE
20) Confidence 0.02 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.96 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox