INT50767

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.63
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
brain 2
striatum 2
cortex 2
plasma 1
neurons 1
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 69 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
dorsal root ganglion 2 100.00 Very High Very High Very High
Nicotine 44 99.98 Very High Very High Very High
Neuropeptide 8 98.40 Very High Very High Very High
Ventral tegmentum 4 96.44 Very High Very High Very High
Nucleus accumbens 4 95.96 Very High Very High Very High
antinociception 10 95.00 High High
intrathecal 2 92.96 High High
narcan 4 91.00 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 100.00 Very High Very High Very High
Anxiety Disorder 24 99.56 Very High Very High Very High
Sprains And Strains 11 98.84 Very High Very High Very High
Targeted Disruption 22 98.04 Very High Very High Very High
Influenza Virus Infection 4 77.84 Quite High
Viral Infection 1 76.12 Quite High
Disease 20 50.00 Quite Low
Depression 2 24.40 Low Low
Drug Induced Neurotoxicity 2 5.88 Low Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in ppENK mRNA level was inhibited by MEC (3 mg/kg, s.c.).
Positive_regulation (increase) of ENK
1) Confidence 0.67 Published 2008 Journal Brain Res. Section Abstract Doc Link 18048009 Disease Relevance 0.09 Pain Relevance 1.55
Indeed, increased ENK availability in mesolimbic sites may promote behavioral responses that detract from the aversiveness of the stressor experience.
Positive_regulation (increased) of ENK associated with enkephalin
2) Confidence 0.66 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.48 Pain Relevance 0.74
The nucleus accumbens, ventral tegmental area, basolateral (BLA), central (CEA) and medial amygdaloid nuclei, prelimbic and infralimbic cortex were assessed for fos-related antigen (FRA) and/or ENK mRNA as well as neuronal activation of ENK neurons (FRA/ENK).
Positive_regulation (activation) of ENK in cortex associated with ventral tegmentum, nucleus accumbens and enkephalin
3) Confidence 0.66 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.34 Pain Relevance 0.77
A single dose of nicotine increased methionine-enkephalin (Met-Enk) immunoreactivity in the striatum of mice in a time-dependent manner.
Positive_regulation (increased) of Enk in striatum associated with nicotine and enkephalin
4) Confidence 0.49 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891117 Disease Relevance 0 Pain Relevance 0.53
Daily administration of nicotine for 14 days increased Met-Enk content and PPE mRNA in the striatum of mice as well.
Positive_regulation (increased) of Enk in striatum associated with nicotine
5) Confidence 0.49 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891117 Disease Relevance 0 Pain Relevance 0.64
In those five strains, faster efflux rates due to PTS-1 correlated with higher concentrations of Met-Enk in brain and plasma.
Positive_regulation (concentrations) of Enk in plasma associated with sprains and strains
6) Confidence 0.49 Published 1997 Journal Alcohol Section Abstract Doc Link 9160801 Disease Relevance 0.46 Pain Relevance 0.25
The processing of proenkephalin was impaired in PC1 KO mouse brains with a decrease in the level of Met-Enkephalin immunoreactivity (ir-Met-Enk) and an accumulation of higher molecular weight processing intermediates containing ir-Met-Enk.
Positive_regulation (accumulation) of Enk in brains associated with targeted disruption and enkephalin
7) Confidence 0.49 Published 2005 Journal Biochemistry Section Abstract Doc Link 15779921 Disease Relevance 0.52 Pain Relevance 0.32
Other treatment schedules included single doses of 20, 10 and 3 mg/kg/day Met-Enk at either 24 h post- or 72 h post-virus exposure, with highly significant increases in NK and CTL activity noted after the latter treatment.
Positive_regulation (increases) of Enk in CTL
8) Confidence 0.45 Published 1995 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7650294 Disease Relevance 0.30 Pain Relevance 0.15
The preproenkephalin (ppENK) mRNA level in spinal cord, but not dorsal root ganglion, was significantly increased 2 h following nicotine administration and recovered to control level 4 h after nicotine (5 mg/kg, s.c.) administration.
Positive_regulation (increased) of ENK in spinal cord associated with ganglion cysts, dorsal root ganglion, nicotine and spinal cord
9) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18048009 Disease Relevance 0.10 Pain Relevance 1.58
The nucleus accumbens, ventral tegmental area, basolateral (BLA), central (CEA) and medial amygdaloid nuclei, prelimbic and infralimbic cortex were assessed for fos-related antigen (FRA) and/or ENK mRNA as well as neuronal activation of ENK neurons (FRA/ENK).
Positive_regulation (activation) of ENK in cortex associated with ventral tegmentum, nucleus accumbens and enkephalin
10) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.34 Pain Relevance 0.78
In the BLA and CEA, 'high-anxiety' mice also displayed increased FRA/ENK after TMT exposure and LD testing.
Positive_regulation (increased) of ENK associated with anxiety disorder and enkephalin
11) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.53 Pain Relevance 0.92
For example, cortical disinhibition using GABAA receptor blockers leads to the occurrence of membrane depolarizations and bursts in D2 receptor-expressing, but not in D1 receptor-expressing, MSSNs (Cepeda et al., 2008), confirming previous studies showing selective activation of enk-containing neurons using expression of immediate-early gene proteins, Fos and Jun B, after cortical disinhibition (Berretta et al., 1997; Parthasarathy and Graybiel, 1997).
Positive_regulation (activation) of enk in neurons
12) Confidence 0.35 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0 Pain Relevance 0.10
Nakagawa et al. [35] reported that the omission of c-Myc transduction resulted in the generation of high-quality iPS cells from mouse TTFs, in which Nanog is strongly activated and the retroviruses are silenced.
Positive_regulation (activated) of Nanog
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
In those five strains, faster efflux rates due to PTS-1 correlated with higher concentrations of Met-Enk in brain and plasma.
Positive_regulation (concentrations) of Enk in brain associated with sprains and strains
14) Confidence 0.17 Published 1997 Journal Alcohol Section Abstract Doc Link 9160801 Disease Relevance 0.46 Pain Relevance 0.25

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