INT50781

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Context Info
Confidence 0.12
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.55
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Map3k5) kinase activity (Map3k5) response to stress (Map3k5)
cytoplasm (Map3k5)
Map3k5 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 14 99.78 Very High Very High Very High
Kinase C 6 93.40 High High
Dopamine 20 86.80 High High
opioid receptor 10 75.00 Quite High
addiction 2 59.76 Quite High
tolerance 2 59.20 Quite High
opiate 4 58.80 Quite High
Enkephalin 2 25.00 Low Low
Analgesic 2 25.00 Low Low
Inflammation 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Stress 3 89.28 High High
Parkinson's Disease 18 78.32 Quite High
Apoptosis 6 67.08 Quite High
Toxicity 2 62.00 Quite High
Neurodegenerative Disease 1 53.20 Quite High
Aging 3 50.64 Quite High
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Wound Infection 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sevoflurane exposure also induced phosphorylation of apoptosis signal-regulating kinase-1 (ASK1), MAP kinase kinases 3 and 6 (MKK3/MKK6), and ATF-2.
Phosphorylation (phosphorylation) of apoptosis signal-regulating kinase-1
1) Confidence 0.12 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.07 Pain Relevance 0
Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.
Phosphorylation (phosphorylation) of kinase-5 associated with agonist
2) Confidence 0.08 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.73
Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.
Phosphorylation (phosphorylation) of kinase-5 associated with agonist
3) Confidence 0.08 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.75
Importantly, Ser(P)-129 is not dephosphorylated by PP2A (72), a finding that we verified (Fig. 7B). a-Syn can be phosphorylated by at least three kinases, including casein kinase 2 (72, 96–99), G-protein-coupled receptor kinase 5 (100), and Polo-like kinases, especially PLK2, which exclusively phosphorylates Ser-129 (101).
Phosphorylation (phosphorylated) of kinase 5
4) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

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