INT50784

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Context Info
Confidence 0.06
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map3k1) cytoplasm (Map3k1)
Map3k1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 99.60 Very High Very High Very High
agonist 7 98.08 Very High Very High Very High
opioid receptor 5 75.00 Quite High
addiction 1 65.96 Quite High
tolerance 1 65.40 Quite High
opiate 2 65.00 Quite High
Enkephalin 1 25.00 Low Low
Analgesic 1 25.00 Low Low
Dopamine 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 5 100.00 Very High Very High Very High
Targeted Disruption 48 84.32 Quite High
Reprotox - General 3 1 58.68 Quite High
Death 7 58.08 Quite High
Contagious Ecthyma 3 16.00 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low
Embryonic Lethality 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of kinase-1 associated with agonist
1) Confidence 0.06 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.80
Here we tested the third strategy in adult mice in which the PTEN-induced putative kinase 1 (PINK1) gene, a Parkinson disease (PD)-associated gene, was targeted.
Positive_regulation (induced) of Gene_expression (disease) of kinase 1 associated with parkinson's disease
2) Confidence 0.03 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.94 Pain Relevance 0

General Comments

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