INT50785

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.22
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map3k1) cytoplasm (Map3k1)
Anatomy Link Frequency
brain 1
Map3k1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.60 Very High Very High Very High
agonist 7 98.08 Very High Very High Very High
depression 73 84.80 Quite High
COX-2 inhibitor 4 83.80 Quite High
opioid receptor 5 75.00 Quite High
addiction 2 65.96 Quite High
tolerance 1 65.40 Quite High
opiate 3 65.00 Quite High
cINOD 5 64.72 Quite High
Eae 4 42.68 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 5 100.00 Very High Very High Very High
Infection 76 95.00 High High
Suicidal Behaviour 124 94.96 High High
Depression 95 94.24 High High
Repression 2 92.36 High High
Apoptosis 14 91.44 High High
Colon Cancer 8 88.52 High High
Targeted Disruption 69 83.64 Quite High
Disease Susceptibility 1 78.96 Quite High
Stress 25 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B–dependent luciferase construct, in the presence or absence of an expression construct for MEKK1.
Gene_expression (expression) of MEKK1
1) Confidence 0.44 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.43 Pain Relevance 0
Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.
Gene_expression (overexpression) of kinase-1 associated with agonist
2) Confidence 0.09 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.80
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Gene_expression (expression) of kinase-1
3) Confidence 0.05 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.69 Pain Relevance 0.21
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Gene_expression (expression) of kinase-1
4) Confidence 0.04 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.69 Pain Relevance 0.20
Here we tested the third strategy in adult mice in which the PTEN-induced putative kinase 1 (PINK1) gene, a Parkinson disease (PD)-associated gene, was targeted.
Gene_expression (disease) of kinase 1 associated with parkinson's disease
5) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.94 Pain Relevance 0
Recently, it has been shown that BDNF and TrkB regulate translational machinery in dendrites.232 Moreover, BDNF induces the expression of Lim kinase 1, a protein kinase whose mRNA translation is inhibited by brain-specific microRNA-134. microRNA 134 is localized in dendrites and its overexpression leads to a decrease in spine size through repression of Lim kinase 1 mRNA translation.233 Thus, studying BDNF/TrkB and other interacting proteins in dendrites will further reveal their novel mechanistic roles in the development of depression/suicidal behavior.



Gene_expression (expression) of kinase 1 in brain associated with suicidal behaviour, depression and repression
6) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.48 Pain Relevance 0.11

General Comments

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