INT50814

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 72
Total Number 74
Disease Relevance 51.37
Pain Relevance 20.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
fibroblast 3
extracellular matrix 3
plasma 2
nucleus 2
band 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 744 100.00 Very High Very High Very High
Osteoarthritis 43 99.84 Very High Very High Very High
palliative 564 99.78 Very High Very High Very High
Paracetamol 16 98.88 Very High Very High Very High
cytokine 285 98.76 Very High Very High Very High
Hyperalgesia 36 98.72 Very High Very High Very High
ischemia 120 98.24 Very High Very High Very High
rheumatoid arthritis 92 98.24 Very High Very High Very High
spinal inflammation 5 98.00 Very High Very High Very High
Inflammation 540 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1921 100.00 Very High Very High Very High
Sprains And Strains 82 99.96 Very High Very High Very High
Metastasis 687 99.92 Very High Very High Very High
Osteoarthritis 46 99.84 Very High Very High Very High
Myocardial Infarction 91 99.76 Very High Very High Very High
Stroke 245 99.72 Very High Very High Very High
Infarction 4 99.68 Very High Very High Very High
Colon Cancer 29 99.48 Very High Very High Very High
Obesity 228 99.36 Very High Very High Very High
Fibrosis 188 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zymography showed that ET and saline injected paws elicited increased gelatinase activity by 9 h after injection.
Positive_regulation (elicited) of gelatinase
1) Confidence 0.68 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.70 Pain Relevance 0.72
Our data revealed that palliative resection activated MMP2 and down-regulated TIMP2.
Positive_regulation (activated) of MMP2 associated with palliative
2) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.04 Pain Relevance 0.57
Lower TIMP2 levels might cause MMP2 activation, which resulted in degradation of the extracellular matrix and increased angiogenesis.
Spec (might) Positive_regulation (activation) of MMP2 in extracellular matrix
3) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.04 Pain Relevance 0.51
The levels of mRNAs and activities of MMP-2 and MMP-9 in the liver were increased from 1 h through 6 h after APAP gavage.
Positive_regulation (increased) of MMP-2 in liver associated with paracetamol
4) Confidence 0.60 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15456921 Disease Relevance 0.40 Pain Relevance 0.89
A significant increase in gelatinase concentration was also observed in the plasma of AS patients but not in the plasma of patients with OA.
Positive_regulation (increase) of gelatinase in plasma associated with spinal inflammation and osteoarthritis
5) Confidence 0.52 Published 1995 Journal Rheumatol. Int. Section Abstract Doc Link 7652465 Disease Relevance 1.98 Pain Relevance 0.91
Although MMP-2 activity was equivalent in BAL of both strains, MMP-2 activity increased substantially in the lung homogenate of the WT mice.
Positive_regulation (increased) of MMP-2 in lung associated with sprains and strains
6) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.25 Pain Relevance 0.11
Other affected members had a missense mutation in exon 2 arginine 101-histidine (R101H) leading to no MMP-2 enzyme activity in serum or fibroblast or both of affected individuals.
Positive_regulation (leading) of MMP-2 in fibroblast
7) Confidence 0.47 Published 2005 Journal Saudi Med J Section Body Doc Link 15756348 Disease Relevance 0.12 Pain Relevance 0
The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.
Positive_regulation (activator) of MMP2 associated with cancer
8) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.13 Pain Relevance 0.37
Our results demonstrate that tumor cells co-cultured with EC-Bcl-2 showed marked increase in activated MMP-2 as compared to tumor cells co-cultured with EC-VC.
Positive_regulation (increase) of MMP-2 associated with cancer
9) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.72 Pain Relevance 0.04
Interestingly, the 90-kD gelatinase was upregulated in the contralateral paw of the ET-injected mice beyond 48 h post injection.
Positive_regulation (upregulated) of gelatinase in paw
10) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.75 Pain Relevance 0.79
Zymography showed that ET and saline injected paws elicited increased gelatinase activity by 9 h after injection.
Positive_regulation (increased) of gelatinase
11) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.70 Pain Relevance 0.72
In the palliative resection group, the number of lung metastatic nodules increased markedly as compared to the sham operation group (14.3 ± 4.7 versus 8.7 ± 3.6, P < 0.05); tumor matrix metalloproteinase 2 (MMP2) activity was elevated by 1.4-fold, with up-regulation of vascular endothelial growth factor (VEGF) and down-regulation of tissue inhibitor of metalloproteinase 2 (TIMP2).
Positive_regulation (elevated) of matrix metalloproteinase 2 in nodules associated with cancer, metalloproteinase and palliative
12) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2976755 Disease Relevance 0.91 Pain Relevance 0.73
In the palliative resection group, the number of lung metastatic nodules increased markedly as compared to the sham operation group (14.3 ± 4.7 versus 8.7 ± 3.6, P < 0.05); tumor matrix metalloproteinase 2 (MMP2) activity was elevated by 1.4-fold, with up-regulation of vascular endothelial growth factor (VEGF) and down-regulation of tissue inhibitor of metalloproteinase 2 (TIMP2).
Positive_regulation (elevated) of MMP2 in nodules associated with cancer, metalloproteinase and palliative
13) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2976755 Disease Relevance 0.90 Pain Relevance 0.72
Gelatin zymography assays clearly showed that tumor MMP2 activity was stronger in the palliative resection group (Figure 2A1); the normalized optical density of the band presenting MMP2 activity was significantly elevated (1.4-fold, P < 0.01, Figure 2A2), in accord with up-regulation of the MMP2 protein level in the palliative resection group, that is, 73.7 ± 8.0 ng/mg versus 57.9 ± 10.1 ng/mg (P < 0.01, Figure 2A3).
Positive_regulation (stronger) of MMP2 in band associated with cancer and palliative
14) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.59 Pain Relevance 0.60
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Positive_regulation (enhances) of MMP2 associated with cancer and palliative
15) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.54
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Positive_regulation (elevates) of MMP2 associated with cancer and palliative
16) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.59
Gelatin zymography assays clearly showed that tumor MMP2 activity was stronger in the palliative resection group (Figure 2A1); the normalized optical density of the band presenting MMP2 activity was significantly elevated (1.4-fold, P < 0.01, Figure 2A2), in accord with up-regulation of the MMP2 protein level in the palliative resection group, that is, 73.7 ± 8.0 ng/mg versus 57.9 ± 10.1 ng/mg (P < 0.01, Figure 2A3).
Positive_regulation (elevated) of MMP2 in band associated with cancer and palliative
17) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.68 Pain Relevance 0.54
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Positive_regulation (elevates) of MMP2 associated with cancer and palliative
18) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.54
This study showed that palliative resection-accelerated HCC metastasis may be attributed, in part, to up-regulation of VEGF and MMP2/TIMP2; SYY reinforced IFN-?
Positive_regulation (up-regulation) of MMP2 associated with hepatocellular cancer, metastasis and palliative
19) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.01 Pain Relevance 0.28
The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.
Positive_regulation (increased) of MMP2 associated with cancer
20) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.13 Pain Relevance 0.37

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