INT50843

Context Info Confidence 0.43 First Reported 1994 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.38 Pain Relevance 1.31

peptidase activity (Phex) Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Anatomy Link Frequency HYP 1 blood 1 MRF 1 neurons 1 NIL 1 Phex (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 3 98.26 anesthesia 3 97.66 midbrain 3 92.80 Central grey 2 84.32 Pain 11 83.44

Disease Link Frequency Relevance Heat Urological Neuroanatomy 6 98.72 Osteophyte 1 96.52 Injury 2 95.76 Pain 10 83.44 Low Back Pain 1 47.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of the dam's MRF and Hyp had no marked influence on the blood flow in the fetal brain.

Positive_regulation (Activation) of Hyp in blood

1) Confidence 0.43 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653643 Disease Relevance 0 Pain Relevance 0.16

The dam's blood pressure was increased immediately after the beginning of MRF or Hyp stimulation.

Positive_regulation (stimulation) of Hyp in MRF

2) Confidence 0.31 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653643 Disease Relevance 0 Pain Relevance 0.16

Under urethan anesthesia, the spontaneous or glutamate-induced discharge of single brain stem neurons in fetuses was decreased by electrical stimulation of the dam's hypothalamus (Hyp).

Positive_regulation (stimulation) of Hyp in neurons associated with glutamate and anesthesia

3) Confidence 0.29 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653643 Disease Relevance 0 Pain Relevance 0.19

Sex differences in beta-EP concentration between the Control groups were found in all tissues except the HYP; beta-EP levels were higher in females in the PAG and NIL, but greater in the AP in males. beta-EP concentration increased in males in the HYP and NIL with formalin 10%; in females, a decrease was found in the HYP with formalin 0.1%.

Positive_regulation (increased) of HYP in HYP associated with urological neuroanatomy

4) Confidence 0.02 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616627 Disease Relevance 0.57 Pain Relevance 0.40

In the nucleus pulposus, the Hyp concentration and the activities of PH and GGT were significantly increased, whereas the water content had decreased.

Positive_regulation (increased) of Hyp in nucleus pulposus

5) Confidence 0.02 Published 1994 Journal J. Orthop. Res. Section Abstract Doc Link 8113947 Disease Relevance 0.25 Pain Relevance 0

Sex differences in beta-EP concentration between the Control groups were found in all tissues except the HYP; beta-EP levels were higher in females in the PAG and NIL, but greater in the AP in males. beta-EP concentration increased in males in the HYP and NIL with formalin 10%; in females, a decrease was found in the HYP with formalin 0.1%.

Positive_regulation (increased) of HYP in NIL associated with urological neuroanatomy

6) Confidence 0.01 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616627 Disease Relevance 0.57 Pain Relevance 0.40

General Comments

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