INT50878

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 5.57
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
chest 6
heart 2
inferior 2
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 21 98.56 Very High Very High Very High
ischemia 3 75.00 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inferior Wall Myocardial Infarction 2 99.88 Very High Very High Very High
Heart Disease 7 99.76 Very High Very High Very High
Coronary Artery Disease 15 99.62 Very High Very High Very High
Pyometra 60 98.80 Very High Very High Very High
Angina 16 98.56 Very High Very High Very High
Myocardial Infarction 23 98.52 Very High Very High Very High
Renal Failure 1 96.20 Very High Very High Very High
Cv General 3 Under Development 5 95.96 Very High Very High Very High
Injury 35 95.28 Very High Very High Very High
Heart Murmurs 1 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used a cardiospecific enzymoimmunometric assay to measure cardiac troponin I (cTnI) in samples serially drawn from 78 patients with acute myocardial infarction (AMI), 7 patients with unstable angina (Braunwald class III), 22 multi-traumatized patients, and in 30 athletes after eccentric exercise, as well as in 101 non-traumatic chest pain patients on admission to the emergency department. cTnI assay crossreactivity with crude human skeletal muscle homogenates was < 0.1%. cTnI could not be detected in athletes or multi-traumatized patients except for 2 trauma patients with myocardial damage.
Positive_regulation (measure) of Positive_regulation (cardiac) of cTnI in chest associated with angina, emergencies, injury and myocardial infarction
1) Confidence 0.50 Published 1996 Journal Clin. Chim. Acta Section Abstract Doc Link 8646813 Disease Relevance 0.80 Pain Relevance 0.24
We used a cardiospecific enzymoimmunometric assay to measure cardiac troponin I (cTnI) in samples serially drawn from 78 patients with acute myocardial infarction (AMI), 7 patients with unstable angina (Braunwald class III), 22 multi-traumatized patients, and in 30 athletes after eccentric exercise, as well as in 101 non-traumatic chest pain patients on admission to the emergency department. cTnI assay crossreactivity with crude human skeletal muscle homogenates was < 0.1%. cTnI could not be detected in athletes or multi-traumatized patients except for 2 trauma patients with myocardial damage.
Positive_regulation (measure) of Positive_regulation (cardiac) of cardiac troponin I in chest associated with angina, emergencies, injury and myocardial infarction
2) Confidence 0.50 Published 1996 Journal Clin. Chim. Acta Section Abstract Doc Link 8646813 Disease Relevance 0.80 Pain Relevance 0.24
Concurrent structural cardiac disease could also induce increased cTnI values especially in elderly pyometra patients, but this was not suspected in any of the clinical cases due to the absence of heart murmurs.
Positive_regulation (induce) of Positive_regulation (increased) of cTnI in heart associated with pyometra, heart murmurs and heart disease
3) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.25 Pain Relevance 0
Furthermore we ruled out relevant CAD as an alternative cause for cTnI elevation in the majority of the cTnI-positive patients.
Positive_regulation (cause) of Positive_regulation (elevation) of cTnI associated with coronary artery disease
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815772 Disease Relevance 1.13 Pain Relevance 0
Cardiac events and positive test results at 30 days and 6-month mortality increased significantly with increasing cTnI values.
Positive_regulation (increased) of Positive_regulation (increasing) of cTnI
5) Confidence 0.25 Published 2004 Journal J. Am. Coll. Cardiol. Section Body Doc Link 15028350 Disease Relevance 0 Pain Relevance 0
During left atrial manipulation our patients suffered from acute chest pain, showed ECG signs of an acute inferior wall myocardial infarction, and increased levels of cardiac Troponin I (cTnI).
Positive_regulation (levels) of Positive_regulation (increased) of cTnI in inferior associated with angina and inferior wall myocardial infarction
6) Confidence 0.20 Published 2004 Journal Europace Section Abstract Doc Link 15018868 Disease Relevance 0.62 Pain Relevance 0.10
We describe the various conditions that may cause an elevated cTnI level and give possible explanations for these findings, and we offer some guidelines for diagnosis in patients with an elevated cTnI.
Spec (may) Positive_regulation (cause) of Positive_regulation (elevated) of cTnI
7) Confidence 0.18 Published 2003 Journal Clin Invest Med Section Abstract Doc Link 12858947 Disease Relevance 0.34 Pain Relevance 0.21
Early sensitivities of creatine kinase (CK), CKMB (activity and mass), CKMM and CKMB isoform ratios, myoglobin, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) were compared to find the most sensitive serum marker for acute myocardial infarction (AMI) during the first hours after onset of chest pain.
Spec (find) Positive_regulation (find) of Positive_regulation (sensitivities) of cTnI in chest associated with angina and myocardial infarction
8) Confidence 0.12 Published 1995 Journal Clin. Chem. Section Abstract Doc Link 7656437 Disease Relevance 0.53 Pain Relevance 0.17
HYPOTHESIS: We sought to test an algorithm for rapid diagnosis of MI and acute coronary syndromes using cardiac troponin I (cTnI) and myoglobin as adjuncts to creatine kinase (CK)-MB.
Positive_regulation (syndromes) of Positive_regulation (using) of cTnI
9) Confidence 0.05 Published 2000 Journal Clin Cardiol Section Body Doc Link 11129678 Disease Relevance 0.09 Pain Relevance 0

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