INT50887

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 1 92.32 High High
Migraine 3 75.00 Quite High
agonist 1 28.80 Quite Low
Disease Link Frequency Relevance Heat
Headache 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural modifications of N- and C-linked (principally hydantoin) analogues at the 5-position were synthesized and their pharmacological activities were utilized to deduce significant steric and electrostatic requirements of the 5-HT1D and 5-HT2A receptor subtypes.
Negative_regulation (deduce) of Positive_regulation (requirements) of 5-HT2A
1) Confidence 0.41 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658443 Disease Relevance 0.07 Pain Relevance 0.12
At day 4, this 5-HT2B-mediated inhibition of the 5-HT1B/1D function can be blocked upon concomitant 5-HT2A activation although a 5-HT2A/PLA2 positive coupling was evidenced.
Negative_regulation (blocked) of Positive_regulation (activation) of 5-HT2A
2) Confidence 0.41 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9651340 Disease Relevance 0 Pain Relevance 0.07

General Comments

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