INT50889

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 1996
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.31
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A, HTR1D) signal transducer activity (HTR1A, HTR1D)
HTR1A (Homo sapiens)
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 97.24 Very High Very High Very High
Serotonin 2 94.84 High High
Substantia nigra 6 94.24 High High
Sumatriptan 11 79.68 Quite High
Migraine 4 75.00 Quite High
Potency 2 70.16 Quite High
monoamine 2 36.28 Quite Low
Neurotransmitter 2 31.56 Quite Low
Disease Link Frequency Relevance Heat
Glioma 2 80.56 Quite High
Headache 4 75.00 Quite High
Cluster Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding experiments at cloned human 5-HT1D alpha, 5-HT1D beta, and 5-HT1A receptors show that all the compounds are very potent and selective ligands for 5-HT1D receptor subtypes.
5-HT1A Binding (ligands) of 5-HT1D
1) Confidence 0.40 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658447 Disease Relevance 0 Pain Relevance 0.33
Most compounds did not differentiate between 5-HT1D alpha and 5-HT1D beta receptors, except methysergide, ritanserin, ocaperidone, risperidone, and ketanserin, which showed 10-60-fold higher affinity for the 5-HT1D alpha receptor.
5-HT1D alpha receptor Neg (except) Binding (affinity) of 5-HT1D
2) Confidence 0.35 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967979 Disease Relevance 0.15 Pain Relevance 0.36
Most compounds did not differentiate between 5-HT1D alpha and 5-HT1D beta receptors, except methysergide, ritanserin, ocaperidone, risperidone, and ketanserin, which showed 10-60-fold higher affinity for the 5-HT1D alpha receptor.
5-HT1D alpha receptor Neg (except) Binding (affinity) of 5-HT1D
3) Confidence 0.35 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967979 Disease Relevance 0.16 Pain Relevance 0.36

General Comments

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