INT50895

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 4.05
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
blood 1
putamen 1
tail 1
neurons 1
GYPA (Homo sapiens)
GYPA - I58T (1)
Pain Link Frequency Relevance Heat
qutenza 1 99.84 Very High Very High Very High
positron emission tomography 184 98.92 Very High Very High Very High
diabetic neuropathy 99 98.92 Very High Very High Very High
adenocard 6 98.72 Very High Very High Very High
Cannabinoid receptor 4 95.24 Very High Very High Very High
Dopamine 312 94.16 High High
imagery 93 87.48 High High
tetrodotoxin 2 86.84 High High
monoamine 24 85.68 High High
Action potential 12 83.12 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 16 99.54 Very High Very High Very High
Diabetic Neuropathy 102 98.92 Very High Very High Very High
Hemolytic Anemia 4 98.52 Very High Very High Very High
Body Weight 17 97.96 Very High Very High Very High
Alcoholic Liver Cirrhosis 4 97.56 Very High Very High Very High
Parkinsonian Disorders 156 96.76 Very High Very High Very High
Cancer 3 91.88 High High
Disease 383 91.52 High High
Neurodegenerative Disease 21 89.36 High High
Targeted Disruption 5 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inexplicable severity of anti-Pr autoimmune haemolytic anaemia led us to test the hypothesis that the haemolysis was primarily due to a change in the function of glycophorin A, on which the Pr antigen is located.
Regulation (change) of glycophorin A associated with hemolytic anemia
1) Confidence 0.60 Published 2002 Journal Br. J. Haematol. Section Abstract Doc Link 12181064 Disease Relevance 0.10 Pain Relevance 0
The role of glycophorin A in stabilizing and, upon aggregation, destabilizing the phospholipid bilayer is discussed.
Regulation (role) of glycophorin A
2) Confidence 0.44 Published 2002 Journal Br. J. Haematol. Section Abstract Doc Link 12181064 Disease Relevance 0.06 Pain Relevance 0.09
These results show that MnPO neurons projecting to the PVN may carry the information from osmosensitive elements and that there is a difference between WKY and SHR in the responsivity of these MnPO neurons to the osmotic stimulation.
Regulation (responsivity) of MnPO in neurons
3) Confidence 0.28 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659288 Disease Relevance 0.13 Pain Relevance 0.06
Thissubstitution may lead to misdirected intracellular trafficking, followed by changes in Mn-SOD activity in the mitochondria [9,10].
Regulation (changes) of Mn-SOD
4) Confidence 0.25 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.96 Pain Relevance 0.14
The Ala(-9)Val polymorphism of the Mn-SOD gene
Regulation (polymorphism) of Mn-SOD
5) Confidence 0.18 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.10 Pain Relevance 0.10
This single subject had parkinsonian symptoms and elevated Mn in the blood and was responsive to l-dopa therapy, a clinical response that has not been observed in Mn-induced parkinsonism.
Regulation (responsive) of Mn in blood associated with parkinson's disease and parkinsonian disorders
6) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.93 Pain Relevance 0.13
One of the animals had a transient decrease in [11C]-raclopride binding to D2R that returned to baseline by the end of the exposure period, and no effect of Mn treatment on [11C]-l-dopa PET was observed.
Neg (no) Regulation (effect) of Mn associated with positron emission tomography
7) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.56
This latter study not only included a naive control group in which the animals did not receive Mn or neuroimaging studies, but it also included an imaged control group in which the neuroimaging studies were done without Mn exposure.
Neg (not) Regulation (receive) of Mn
8) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.14 Pain Relevance 0.27
In a preliminary report in which four Mn-exposed animal were used, they found no significant effect of Mn exposure (mean cumulative Mn dose, 165.5 mg Mn/kg body weight; range, 152–174 mg Mn/kg body weight) on DAT or D2R receptor levels using autoradiography or tyrosine hydroxylase immunohistochemistry, or on the concentration of dopamine and its metabolite homovanillic acid (HVA) measured by HPLC with electrochemical detection in the caudate or putamen, relative to naive controls (Guilarte et al. 2006a).
Neg (no) Regulation (effect) of Mn in putamen associated with dopamine and body weight
9) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.19 Pain Relevance 0.29
The disagreement observed between Mn-SOD protein content and its activity in the AO adults is intriguing and suggests that Mn-SOD activity may be modulated by post-translational modification [66].
Spec (may) Regulation (modulated) of Mn-SOD
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.07 Pain Relevance 0
Another functional polymorphism of the Mn-SOD gene, Ile58Thr in exon 3, affects the stability of the Mn-SOD tetramer and reduces the activity of the enzyme [14].
Regulation (affects) of Mn-SOD (I58T)
11) Confidence 0.09 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.95 Pain Relevance 0.11
With respect to the junctional complex involving the spectrin tail, there are significant changes in the level of a number of proteins including tropomodulin, tropomyosin, adducin, glycophorin, dematin, and the F-actin capping protein.
Regulation (changes) of glycophorin in tail
12) Confidence 0.02 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 0.34 Pain Relevance 0
We attribute this increase to balanced inhibitory and excitatory synaptic input [13] and conclude that temporal processing in MNs could be affected by synaptic conductance during network activity.


Regulation (affected) of MNs
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0.11
The activities of the recombinant protein expressed in Escherichia coli were not affected by capsaicin, EGCg, and other ENOX2-inhibiting substances.
Neg (not) Regulation (affected) of recombinant protein associated with qutenza
14) Confidence 0.00 Published 2008 Journal Biochemistry Section Abstract Doc Link 19055324 Disease Relevance 0.09 Pain Relevance 0.10

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