INT50929

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Context Info
Confidence 0.24
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.50
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
head 1
urine 1
hs (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.48 Very High Very High Very High
noradrenaline 2 98.78 Very High Very High Very High
Serotonin 2 98.18 Very High Very High Very High
depression 2 96.76 Very High Very High Very High
antidepressant 2 95.08 Very High Very High Very High
fluoxetine 1 94.48 High High
Desipramine 1 93.88 High High
antagonist 1 81.08 Quite High
Inflammation 9 73.28 Quite High
qutenza 2 70.52 Quite High
Disease Link Frequency Relevance Heat
Shock 276 100.00 Very High Very High Very High
Natriuresis 3 99.98 Very High Very High Very High
Depression 2 96.76 Very High Very High Very High
Insulin Resistance 75 95.12 Very High Very High Very High
Disorders Of Creatine Metabolism 3 93.56 High High
Injury 2 91.60 High High
Toxicity 4 81.48 Quite High
Diabetes Mellitus 33 77.44 Quite High
Obesity 30 75.84 Quite High
Pressure And Volume Under Development 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Par excretion into urine was increased following HS.
Positive_regulation (increased) of HS in urine associated with paracetamol
1) Confidence 0.24 Published 1995 Journal Yao Xue Xue Bao Section Abstract Doc Link 7660799 Disease Relevance 0.34 Pain Relevance 0.63
To clarify the action of HS and MES on Akt activation, we determined their time-dependent effect.
Positive_regulation (activation) of HS associated with shock
2) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.05 Pain Relevance 0
Knockdown of Hsp72 by siRNA in these cells reduced the effect of HS+MES (Fig. 9F), suggesting that the effect of HS+MES is partly mediated by Hsp72.
Positive_regulation (effect) of HS associated with shock
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.93 Pain Relevance 0
The effect of HS+MES on insulin signaling is likely through the capacity of electrical signal to trigger the activation of Akt (Fig. 8, [8]) and of HS to up-regulate Hsp72, which in turn inhibits JNK and activates the insulin signaling pathway (Fig. 4C, Fig. 9 [24], [41]).
Positive_regulation (activation) of HS associated with shock
4) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.24 Pain Relevance 0.10
Water and sodium balance increased in CAP-HS rats compared with CON-HS (water balance, 20.2 +/- 1.5 vs. 15.5 +/- 1.9 ml/day; sodium balance, 11.9 +/- 3.1 vs. 2.4 +/- 0.3 meq/day, respectively; P < 0.05).
Positive_regulation (increased) of HS associated with natriuresis
5) Confidence 0.04 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15994858 Disease Relevance 0.86 Pain Relevance 0.11
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls.
Positive_regulation (induced) of head twitch response in head associated with desipramine, antidepressant, depression, noradrenaline, serotonin and fluoxetine
6) Confidence 0.03 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.10 Pain Relevance 0.48

General Comments

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