INT50932

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 24.90
Pain Relevance 16.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 13
spinal 8
macrophages 4
lung 4
aorta 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 147 100.00 Very High Very High Very High
cytokine 101 100.00 Very High Very High Very High
Inflammatory marker 23 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
opioid receptor 2 99.98 Very High Very High Very High
Morphine 22 99.68 Very High Very High Very High
Pain 21 99.50 Very High Very High Very High
antagonist 23 99.32 Very High Very High Very High
tolerance 16 99.32 Very High Very High Very High
allodynia 9 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 208 100.00 Very High Very High Very High
INFLAMMATION 196 100.00 Very High Very High Very High
Necrosis 25 100.00 Very High Very High Very High
Nervous System Injury 49 99.90 Very High Very High Very High
Lung Injury 69 99.88 Very High Very High Very High
Cardiovascular Disease 5 99.54 Very High Very High Very High
Pain 11 99.50 Very High Very High Very High
Sickle Cell Anemia 9 99.46 Very High Very High Very High
Infection 1 99.36 Very High Very High Very High
Melanoma 55 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin restored NK activity in both male and female rats but attenuated surgery-induced interleukin-6 increases only in the male rats.
Positive_regulation (induced) of Positive_regulation (increases) of interleukin-6
1) Confidence 0.69 Published 2002 Journal J Pain Section Abstract Doc Link 14622754 Disease Relevance 0.89 Pain Relevance 0.42
Collectively, these data suggest a unique mechanism by which stimulation of central opioid receptors results in the elevation of plasma IL-6 through autonomic activation specifically of the adrenal cortex.
Positive_regulation (results) of Positive_regulation (elevation) of IL-6 in autonomic associated with opioid receptor
2) Confidence 0.50 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.75
The patients with ongoing pain displayed significantly elevated IL-6 levels and an attenuated elevation of cortisol secretion after awakening compared to the two other groups.
Positive_regulation (elevated) of Positive_regulation (elevated) of IL-6 associated with pain
3) Confidence 0.50 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453216 Disease Relevance 0.84 Pain Relevance 0.48
We conclude from these data that increases in IL-6 and nerve growth factor may contribute to the development of mechanical allodynia after trigeminal nerve injury, but they are not specifically correlated with the onset or duration of pain behaviors.
Spec (may) Positive_regulation (contribute) of Positive_regulation (increases) of IL-6 in nerve associated with pain, fifth nerve, nervous system injury, allodynia and nerve growth factor
4) Confidence 0.49 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11369318 Disease Relevance 0.71 Pain Relevance 0.73
In conclusion, we provide evidence that LPS action on IL-6 and PGE2 release can be ascribed to the activation of different transduction mechanisms, which can be pharmacologically dissected with the aid of anti-inflammatory drugs.
Positive_regulation (ascribed) of Positive_regulation (action) of IL-6 associated with inflammation and cinod
5) Confidence 0.49 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.17 Pain Relevance 0.32
Capsaicin-induced desensitization also resulted in significantly higher plasma levels of IL-6 and TNF 1 but not 4 h after LPS challenge.
Positive_regulation (resulted) of Positive_regulation (levels) of IL-6 in plasma
6) Confidence 0.49 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11435748 Disease Relevance 0.07 Pain Relevance 0
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (potentiated) of interleukin-6 associated with necrosis, cancer, tolerance and morphine
7) Confidence 0.48 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.36 Pain Relevance 0.70
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (potentiated) of IL-6 associated with necrosis, cancer, tolerance and morphine
8) Confidence 0.48 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.36 Pain Relevance 0.70
Indeed, circulating IL-6 levels are elevated in patients with acute myocardial infarction (AMI), and also in patients with unstable, but not with stable angina.
Neg (not) Positive_regulation (elevated) of Neg (not) Positive_regulation (elevated) of IL-6 associated with angina and myocardial infarction
9) Confidence 0.47 Published 2001 Journal Clin Cardiol Section Abstract Doc Link 11714126 Disease Relevance 0.94 Pain Relevance 0.21
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Positive_regulation (mediated) of Positive_regulation (elevated) of interleukin-6 in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
10) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.77 Pain Relevance 1.28
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Positive_regulation (elevated) of Positive_regulation (elevated) of IL-6 in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
11) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.75 Pain Relevance 1.27
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Positive_regulation (elevated) of Positive_regulation (elevated) of interleukin-6 in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
12) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.75 Pain Relevance 1.27
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Positive_regulation (mediated) of Positive_regulation (elevated) of IL-6 in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
13) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.77 Pain Relevance 1.28
In a separate group of rats, interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF-alpha) and cytokine-induced neutrophil chemoattractant (CINC-1) concentrations were measured in plasma and tail tissue samples taken at the site of injection, 3 h, 6 h and 24 h after injections.
Positive_regulation (measured) of Positive_regulation (cytokine-induced) of IL-6 in plasma associated with necrosis, cancer and cytokine
14) Confidence 0.43 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17692348 Disease Relevance 0.89 Pain Relevance 0.65
Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta.
Positive_regulation (caused) of Positive_regulation (increase) of interleukin 6 in aorta
15) Confidence 0.42 Published 2009 Journal Angiology Section Abstract Doc Link 19508977 Disease Relevance 0.24 Pain Relevance 0.32
OBJECTIVES: To determine if increased inflammatory activity, as reflected by interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) levels, is present in patients with stable angina pectoris and if IL-6 levels on admission to the coronary care unit in patients with acute myocardial infarction (AMI) are related to heart failure and fever response.
Positive_regulation (increased) of Positive_regulation (increased) of IL-6 in heart associated with stable angina pectoris, angina, inflammation, antagonist, fever and myocardial infarction
16) Confidence 0.42 Published 2000 Journal J. Intern. Med. Section Abstract Doc Link 10947882 Disease Relevance 0.62 Pain Relevance 0.31
The elevation of IL-6 accounted for a greater proportion of the variations of the T(3) and rT(3) in the control group B than in the T(4)-treated group A.
Positive_regulation (accounted) of Positive_regulation (elevation) of IL-6
17) Confidence 0.41 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 14564683 Disease Relevance 0 Pain Relevance 0
CONCLUSION: An up-regulation of IL-6 by met-enk was mediated through an increase in transcriptional activity and stability of IL-6 mRNA.


Positive_regulation (mediated) of Positive_regulation (up-regulation) of IL-6
18) Confidence 0.41 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7660811 Disease Relevance 0 Pain Relevance 0
CONCLUSION: An up-regulation of IL-6 by met-enk was mediated through an increase in transcriptional activity and stability of IL-6 mRNA.


Positive_regulation (increase) of Positive_regulation (stability) of IL-6
19) Confidence 0.41 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7660811 Disease Relevance 0 Pain Relevance 0
CONCLUSION: An up-regulation of IL-6 by met-enk was mediated through an increase in transcriptional activity and stability of IL-6 mRNA.


Positive_regulation (mediated) of Positive_regulation (increase) of IL-6
20) Confidence 0.41 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7660811 Disease Relevance 0 Pain Relevance 0

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