INT50933

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 24.31
Pain Relevance 11.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
spinal cord 2
embryos 1
lymph nodes 1
macrophage 1
bowel 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 271 100.00 Very High Very High Very High
cytokine 145 100.00 Very High Very High Very High
antagonist 9 100.00 Very High Very High Very High
Neuropathic pain 23 99.86 Very High Very High Very High
Chronic pancreatitis 7 99.80 Very High Very High Very High
dorsal root ganglion 5 99.08 Very High Very High Very High
Spinal cord 39 99.02 Very High Very High Very High
cva 158 98.72 Very High Very High Very High
Neuritis 9 98.68 Very High Very High Very High
nociceptor 1 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 346 100.00 Very High Very High Very High
Cancer 29 100.00 Very High Very High Very High
Necrosis 17 100.00 Very High Very High Very High
Injury 154 99.96 Very High Very High Very High
Congenital Anomalies 20 99.92 Very High Very High Very High
Neuropathic Pain 35 99.86 Very High Very High Very High
Pancreatitis 7 99.80 Very High Very High Very High
Hyperoxia 98 99.78 Very High Very High Very High
Adenocarcinoma 6 99.66 Very High Very High Very High
Immunization 1 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a polymorphism of the IL-6 gene that will result in abnormalities in IL-6 transcription rate.
Transcription (transcription) of IL-6 associated with congenital anomalies
1) Confidence 0.72 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.36 Pain Relevance 0.30
Although this was not demonstrated by these authors, this abnormal IL-6 transcription could well lead to an abnormal reaction to fat emboli in the lungs and the development of a full blown fat embolism syndrome.
Transcription (transcription) of IL-6 in fat associated with syndrome, cva and fat embolism
2) Confidence 0.72 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.23 Pain Relevance 0.29
SNL resulted also in a massive induction of IL-6 mRNA expression in dorsal root ganglia and increased concentration of IL-6 in dorsal spinal cord.
Transcription (expression) of IL-6 in spinal cord associated with spinal cord
3) Confidence 0.69 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.63 Pain Relevance 0.88
The IL-6 levels were raised in the three groups reaching a peak at 12 hours after surgery (Figure 5).
Transcription (raised) of IL-6
4) Confidence 0.69 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.35 Pain Relevance 0.17
In PA and CP patients Il-6 serum levels were significantly higher than in the control group (P < 0.01).
Transcription (levels) of Il-6 associated with adenocarcinoma and chronic pancreatitis
5) Confidence 0.58 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18661238 Disease Relevance 1.13 Pain Relevance 0.44
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Transcription (concentrations) of IL6 associated with hyperoxia
6) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.67 Pain Relevance 0.28
To study the role of key pro- and anti-inflammatory cytokines in a chronic constriction model of neuropathic pain, mRNA expression of TNF, IL-1beta, IL-6, and IL-10 was quantified using competitive RT-PCR.
Transcription (expression) of IL-6 associated with inflammation, neuropathic pain and cytokine
7) Confidence 0.56 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11358451 Disease Relevance 0.76 Pain Relevance 0.90
Comparing the curves of IRS-1 and IL-6 receptor 1 mRNA reveals a delay time of 30 h between the second decline of IRS-1 and its driving force.
Transcription (curves) of IL-6
8) Confidence 0.54 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
RT-PCR demonstrated that transcripts of IL-6 gene significantly increased 3 h after ligation in the nonembolized lobes.
Transcription (transcripts) of IL-6 gene in lobes
9) Confidence 0.54 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16716357 Disease Relevance 0.07 Pain Relevance 0
Although the IL-6 levels dropped after 12 hours in all 3 groups, it did not reach the pre operative levels at 24 hours.
Transcription (levels) of IL-6
10) Confidence 0.53 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.19 Pain Relevance 0.24
Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour.
Transcription (levels) of IL-6 associated with cancer
11) Confidence 0.52 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11298095 Disease Relevance 1.13 Pain Relevance 0.35
The purpose of this study was to examine whether mRNA of interleukin-A2, interleukin-6, phospholipase A2, and nitric oxide synthase was expressed in the nerve root and dorsal root ganglion of an animal model in which exposure to the nucleus pulposus induced mechanical hyperalgesia, a pain-related behavior.
Transcription (expressed) of interleukin-6 in nerve associated with ganglion cysts, pain, dorsal root ganglion and hyperalgesia
12) Confidence 0.50 Published 1999 Journal J. Orthop. Res. Section Abstract Doc Link 10632462 Disease Relevance 0.36 Pain Relevance 0.30
Thirty pancreatic cancer patients (54.5%) had detectable levels, although interleukin-6 levels were detectable in only one healthy control and in two chronic pancreatitis patients.
Transcription (levels) of interleukin-6 associated with pancreatic cancer and chronic pancreatitis
13) Confidence 0.47 Published 1998 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 9491135 Disease Relevance 1.45 Pain Relevance 0.23
, IL-6, and iNOS were demonstrated after peripheral LPS injection in previous reports (Vallieres and Rivest 1997; Satta et al 1998; Tonelli et al 2003), this is the first study showing that HO-1, IL-1?
Transcription (demonstrated) of IL-6
14) Confidence 0.46 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526382 Disease Relevance 0 Pain Relevance 0.14
IL-6 levels were high in patients with AMI (38.9 +/- 75.6 ng L-1).
Transcription (levels) of IL-6
15) Confidence 0.45 Published 2000 Journal J. Intern. Med. Section Body Doc Link 10947882 Disease Relevance 0.22 Pain Relevance 0
RESULTS: Met-enk stimulated IL-6 mRNA expression and increased its stability.
Transcription (expression) of IL-6
16) Confidence 0.43 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7660811 Disease Relevance 0 Pain Relevance 0
In the present study, the serum IL-6 level was not detected in both groups before and immediately after surgery.
Neg (not) Transcription (detected) of IL-6
17) Confidence 0.43 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2966708 Disease Relevance 1.00 Pain Relevance 0.26
Before operation, the serum IL-6 level was not detected in both groups.
Neg (not) Transcription (detected) of IL-6
18) Confidence 0.43 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2966708 Disease Relevance 0 Pain Relevance 0.08
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Transcription (transcript) of IL-6 associated with hyperoxia
19) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.35 Pain Relevance 0.19
However, we observed a significant up-regulation of IL-6 receptor type 1 transcription.
Transcription (transcription) of IL-6
20) Confidence 0.42 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.48 Pain Relevance 0.21

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