INT5095

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Context Info
Confidence 0.81
First Reported 1981
Last Reported 2009
Negated 2
Speculated 2
Reported most in Abstract
Documents 185
Total Number 187
Disease Relevance 28.09
Pain Relevance 62.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 21
somatotrophs 13
hypothalamus 12
plasma 8
neurons 5
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 629 100.00 Very High Very High Very High
Clonidine 442 100.00 Very High Very High Very High
adenocard 26 100.00 Very High Very High Very High
Morphine 19 100.00 Very High Very High Very High
Nerve growth factor 196 99.98 Very High Very High Very High
antagonist 326 99.92 Very High Very High Very High
dexamethasone 10 99.76 Very High Very High Very High
narcan 71 99.72 Very High Very High Very High
Neurotransmitter 102 99.68 Very High Very High Very High
qutenza 8 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 169 99.98 Very High Very High Very High
Pituitary Cancer 89 99.88 Very High Very High Very High
Obesity 88 99.78 Very High Very High Very High
Syndrome 33 99.72 Very High Very High Very High
Acromegaly 17 99.52 Very High Very High Very High
Aging 214 99.40 Very High Very High Very High
Reprotox - General 2 7 99.36 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

20 99.16 Very High Very High Very High
Carcinoid 42 99.14 Very High Very High Very High
Neuroendocrine Cancer 4 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation by alpha-adrenergic mechanisms of the secretion of growth hormone-releasing factor (GRF) from perifused rat hypothalamus.
Localization (secretion) of GRF in hypothalamus
1) Confidence 0.81 Published 1986 Journal Endocrinology Section Title Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.24
Stimulation by alpha-adrenergic mechanisms of the secretion of growth hormone-releasing factor (GRF) from perifused rat hypothalamus.
Localization (secretion) of growth hormone-releasing factor in hypothalamus
2) Confidence 0.81 Published 1986 Journal Endocrinology Section Title Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.24
These findings suggest that alpha 2-adrenergic mechanisms play a role in stimulating GRF release from the hypothalamus in rats.
Localization (release) of GRF in hypothalamus
3) Confidence 0.81 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.25
The stimulatory effect of clonidine (10(-4) M) on GRF release in the presence of propranolol was inhibited by yohimbine (10(-4) M), an alpha 2-adrenergic blocking agent.
Localization (release) of GRF associated with clonidine
4) Confidence 0.81 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.27
A high potassium concentration (56 mM) stimulated GRF release from the hypothalamus.
Localization (release) of GRF in hypothalamus
5) Confidence 0.81 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.24
In the presence of propranolol (10(-5) M), a beta-adrenergic blocking agent, clonidine (10(-5) and 10(-4) M) stimulated GRF release more prominently in a dose-related manner, whereas propranolol (10(-5) and 10(-4) M) by itself did not affect the spontaneous GRF release.
Localization (release) of GRF associated with clonidine
6) Confidence 0.81 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.28
Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats.
Localization (release) of GHRH in pituitary associated with clonidine
7) Confidence 0.80 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3092819 Disease Relevance 0 Pain Relevance 0.35
It is known that excessive GHRH secretion in patients with gastroenteropancreatic tumors secreting GHRH results in acromegaly and somatotrope hyperplasia.
Localization (secretion) of GHRH in somatotrope associated with acromegaly, cancer and hyperplasia
8) Confidence 0.80 Published 2005 Journal Endokrynol Pol Section Abstract Doc Link 16821213 Disease Relevance 0.47 Pain Relevance 0
We have examined the effect of glucose and FFA on GH-releasing factor (GHRF)-mediated GH secretion in rats under pentobarbital anesthesia.
Localization (secretion) of GHRF associated with anesthesia
9) Confidence 0.80 Published 1986 Journal Endocrinology Section Abstract Doc Link 2870916 Disease Relevance 0.27 Pain Relevance 0.10
While basal GH secretion from the cultured pituitary cells was similar in the two groups (49.7 +/- 3.5 vs. 47.8 +/- 2.7 ng/ml X 4 h for the 2- and 18-month old rats, respectively), the GH-releasing ability of GRF was partially but significantly impaired in cells derived from both 14- and 18-month old rats; 100 nM GRF stimulated the release of 96.7 +/- 1.8 ng/ml X 4 h in the 18-month old rats as opposed to 115.0 +/- 6.0 (P less than 0.05) ng/ml X 4 h in the 2-month-old rats.
Localization (releasing) of GRF in pituitary
10) Confidence 0.80 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.31 Pain Relevance 0.08
The data suggest that an opioid trigger may stimulate complementary central (feeding effects) and peripheral (GH release) GRF actions via the arcuate nucleus.
Localization (release) of GRF in arcuate nucleus associated with opioid
11) Confidence 0.80 Published 1997 Journal Peptides Section Abstract Doc Link 9149291 Disease Relevance 0 Pain Relevance 0.51
These results indicate that 1) functional activation of alpha-2 adrenergic receptors by CLO increases GHRH release from the hypothalamus, 2) CLO, via GHRH, increases GH secretion and biosynthesis, which in turn feeds back in the hypothalamus to reduce GHRH biosynthesis, and 3) reduction of hypothalamic GH-stimulatory activity tones down the initial pituitary somatotropic hyperfunction.
Localization (release) of GHRH in hypothalamus associated with clonidine
12) Confidence 0.80 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 1.00
GHRH-induced secretion was similar on days 45, 60 and 90 in orchidectomized and sham-operated animals.
Localization (secretion) of GHRH
13) Confidence 0.80 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2109443 Disease Relevance 0 Pain Relevance 0.09
Viewed together, these data indicate that in infant rats CLO releases GH via GRF release and that the somatotropes respond earlier to GRF (5 days) than the GRF-secreting structures do to alpha 2-adrenergic stimulation (10 days).
Localization (release) of GRF in somatotropes associated with clonidine
14) Confidence 0.79 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.75
These results suggest that reduction of both hypothalamic GRF and somatostatin release contribute to the impaired GH secretion in VMH lesioned rats.
Localization (release) of GRF associated with somatostatin
15) Confidence 0.78 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.47
Although the actions of dermorphin, 2549, and GHRP on GH release are GHRH dependent, release of endogenous GHRH does not explain how GH is released synergistically by the combination of these peptides.
Localization (release) of GHRH
16) Confidence 0.77 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.70
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Localization (release) of GHRH in hypothalamus associated with clonidine
17) Confidence 0.77 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.78
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Localization (release) of GH-releasing hormone in hypothalamus associated with clonidine
18) Confidence 0.77 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.78
In 10-day-old rats made hypothyroid by giving dams propylthiouracil (PTU) in the drinking water since the day of parturition, simultaneous radioimmunoassay (RIA) determinations of basal and stimulated growth hormone (GH) secretion, hypothalamic GH-releasing hormone (GHRH)-like immunoreactivity (LI) content, immunocytochemical localization of somatotrophs, and hypothalamic GHRH-LI-positive structures were performed.
Localization (localization) of GHRH in somatotrophs
19) Confidence 0.77 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3124121 Disease Relevance 0 Pain Relevance 0
In 10-day-old rats made hypothyroid by giving dams propylthiouracil (PTU) in the drinking water since the day of parturition, simultaneous radioimmunoassay (RIA) determinations of basal and stimulated growth hormone (GH) secretion, hypothalamic GH-releasing hormone (GHRH)-like immunoreactivity (LI) content, immunocytochemical localization of somatotrophs, and hypothalamic GHRH-LI-positive structures were performed.
Localization (secretion) of GH-releasing hormone in somatotrophs
20) Confidence 0.77 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3124121 Disease Relevance 0 Pain Relevance 0

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