INT50957

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 134
Total Number 137
Disease Relevance 79.08
Pain Relevance 42.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 6
neutrophil 5
blood 3
spikes 2
adrenal cortex 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 855 100.00 Very High Very High Very High
cytokine 519 100.00 Very High Very High Very High
agonist 302 100.00 Very High Very High Very High
Pain 122 100.00 Very High Very High Very High
anesthesia 83 100.00 Very High Very High Very High
antagonist 80 100.00 Very High Very High Very High
Inflammatory mediators 41 100.00 Very High Very High Very High
chemokine 30 100.00 Very High Very High Very High
neuralgia 3 100.00 Very High Very High Very High
anakinra 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 948 100.00 Very High Very High Very High
Cancer 112 100.00 Very High Very High Very High
Pain 105 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Multiple Myeloma 35 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 33 100.00 Very High Very High Very High
Hypoglycemia 7 100.00 Very High Very High Very High
Fever 59 99.96 Very High Very High Very High
Arthritis 277 99.84 Very High Very High Very High
Lung Injury 128 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adrenal cortex, IL-6 mRNA was unaltered and IL-6 receptor mRNA was significantly decreased under these same conditions.
Negative_regulation (decreased) of IL-6 in adrenal cortex
1) Confidence 0.59 Published 1999 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 10503733 Disease Relevance 1.15 Pain Relevance 0.80
Among naive subjects in whom tolerance was induced, bronchoalveolar lavage fluid percent neutrophils and interleukin-6 (IL-6) levels were significantly decreased compared with subjects who underwent only a single exposure.
Negative_regulation (decreased) of IL-6 in neutrophils associated with tolerance
2) Confidence 0.58 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 11094787 Disease Relevance 0.16 Pain Relevance 0.36
CONCLUSION: The extracts from rabbit skin inflamed by vaccinia virus have definite effects for rapid pain relief, and can effectively decrease the serum IL-6 level in elderly patients with PHN.


Negative_regulation (decrease) of IL-6 in skin
3) Confidence 0.58 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 18159027 Disease Relevance 0.06 Pain Relevance 0
Among naive subjects in whom tolerance was induced, bronchoalveolar lavage fluid percent neutrophils and interleukin-6 (IL-6) levels were significantly decreased compared with subjects who underwent only a single exposure.
Negative_regulation (decreased) of interleukin-6 in neutrophils associated with tolerance
4) Confidence 0.58 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 11094787 Disease Relevance 0.16 Pain Relevance 0.36
Palliative steroid therapy with 20 mg/day of prednisolone resulted in the decline of serum IL-6 level and, simultaneously, improved anorexia and oral intake.
Negative_regulation (decline) of IL-6 associated with appetite loss and palliative
5) Confidence 0.58 Published 1996 Journal J Pain Symptom Manage Section Abstract Doc Link 8803383 Disease Relevance 0.70 Pain Relevance 0.17
Perineural CGRP antagonists also dramatically reduced IL-6 level in injured nerves.
Negative_regulation (reduced) of IL-6 in nerves associated with antagonist and calcitonin gene-related peptide
6) Confidence 0.58 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.89 Pain Relevance 1.31
Median cord blood interleukin-6 levels were reduced with the high-dose steroid treatment, but this result was statistically significant only between the high-dose and placebo groups (24.0 +/- 38.5 vs 32.0 +/- 95.0 pg/mL, respectively; P = .02).
Negative_regulation (reduced) of interleukin-6 in blood
7) Confidence 0.55 Published 2006 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 16875647 Disease Relevance 0.05 Pain Relevance 0
Liver IL-6 mRNA (2 and 4 hours) and protein (4 hours) levels were also suppressed significantly in both the laparotomy and laparoscopic groups (P < 0.05).
Negative_regulation (suppressed) of IL-6 mRNA in Liver
8) Confidence 0.55 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.41 Pain Relevance 0.22
CONCLUSIONS: Short-term treatment with simvastatin reduces plasma IL-6.
Negative_regulation (reduces) of IL-6 in plasma
9) Confidence 0.54 Published 2009 Journal Clin Invest Med Section Body Doc Link 19640331 Disease Relevance 0.12 Pain Relevance 0
CONCLUSIONS: The IL-6 levels had decreased significantly after antibiotic therapy in patients with CP/CPPS, suggesting a bacterial inflammatory character.
Negative_regulation (decreased) of IL-6
10) Confidence 0.53 Published 2008 Journal Urology Section Body Doc Link 18468661 Disease Relevance 0 Pain Relevance 0
CO(2)-pneumoperitoneum increased survival at 48 hours compared with LPS control (P <.05), and decreased interleukin-6 plasma levels at 2 hours (P <.05).
Negative_regulation (decreased) of interleukin-6 in plasma associated with pneumoperitoneum
11) Confidence 0.53 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 16368488 Disease Relevance 0.61 Pain Relevance 0.29
IL-6 levels were significantly reduced in patients receiving cilostazol as compared with those receiving placebo or pentoxifylline.
Negative_regulation (reduced) of IL-6
12) Confidence 0.51 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583728 Disease Relevance 0.67 Pain Relevance 0.43
To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC.
Spec (whether) Negative_regulation (reduction) of IL-6 associated with restless leg syndrome
13) Confidence 0.51 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583728 Disease Relevance 0.66 Pain Relevance 0.45
When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-1alpha were also marginally decreased in rats fed with Lyprinol.
Negative_regulation (decreased) of IL-6
14) Confidence 0.49 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 19227651 Disease Relevance 0.63 Pain Relevance 0.44
Compared with D, Cr-P supplementation showed a decrease in TNF-alpha (P=0.02), IL-6 (P=0.02), and LP (P=0.01).
Negative_regulation (decrease) of IL-6
15) Confidence 0.47 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17854708 Disease Relevance 0.31 Pain Relevance 0.17
This latter finding is discrepant with the study by de Visser and collaborators [15] who showed significant decrease of MCP-1 and IL-6 mRNAs on day 10 of exposure.
Negative_regulation (decrease) of IL-6
16) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.53 Pain Relevance 0.28
RESULTS: We found that lidocaine (in a dose-dependent manner) significantly attenuated p38 MAPK activation triggered by 1 mM ATP, by inhibiting the transcription of 3 cytokine messenger RNAs and causing a decrease in their respective protein concentrations (TNF-alpha, IL-1beta, and IL-6, P < 0.05, vs. the ATP group).
Negative_regulation (decrease) of IL-6
17) Confidence 0.46 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20686009 Disease Relevance 0 Pain Relevance 0
A single dose of dexamethasone reduces IL-6 and PNE levels associated with CPB.
Negative_regulation (reduces) of IL-6 associated with dexamethasone
18) Confidence 0.44 Published 2008 Journal ASAIO J. Section Abstract Doc Link 18356656 Disease Relevance 0.57 Pain Relevance 0.29
Despite the significant reductions in IL-6 and PNE, there was no effect on clinical outcomes.
Negative_regulation (reductions) of IL-6
19) Confidence 0.44 Published 2008 Journal ASAIO J. Section Abstract Doc Link 18356656 Disease Relevance 0.56 Pain Relevance 0.28
Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain.
Negative_regulation (Suppression) of interleukin-6 associated with neuralgia and neuropathic pain
20) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16687137 Disease Relevance 0.91 Pain Relevance 1.23

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