INT5096

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 79
Total Number 83
Disease Relevance 42.26
Pain Relevance 20.62

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RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
nerve 6
brain 4
platelet 3
neuronal 3
neurons 3
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 147 100.00 Very High Very High Very High
Nerve growth factor 95 100.00 Very High Very High Very High
Opioid 14 99.98 Very High Very High Very High
Catecholamine 5 99.98 Very High Very High Very High
Dopamine 71 99.90 Very High Very High Very High
Intracerebroventricular 8 99.86 Very High Very High Very High
Inflammation 228 99.84 Very High Very High Very High
anesthesia 38 99.82 Very High Very High Very High
Somatostatin 11 99.80 Very High Very High Very High
antagonist 52 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 106 100.00 Very High Very High Very High
Necrosis 35 100.00 Very High Very High Very High
Adhesions 34 100.00 Very High Very High Very High
Leukemia 14 100.00 Very High Very High Very High
Natriuresis 7 100.00 Very High Very High Very High
Apoptosis 252 99.98 Very High Very High Very High
Thrombosis 12 99.98 Very High Very High Very High
INFLAMMATION 277 99.84 Very High Very High Very High
Burns 9 99.84 Very High Very High Very High
Brain Hemorrhage 15 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the ACR neuropathy had been established, 12 of the rats were administered 4-MC for 2 weeks, and the other 10 were injected with phosphate-buffered saline alone. 4-MC-administered ACR neuropathy rats showed improvement, i.e., a decrease in landing foot spread distance, increase in motor nerve conduction velocity and increase in nerve growth factor content in the sciatic nerves in comparison with the corresponding values for ACR neuropathy rats given phosphate-buffered saline alone.
Positive_regulation (increase) of factor in sciatic nerves associated with nerve growth factor, neuropathic pain and sciatic nerve
1) Confidence 0.60 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558436 Disease Relevance 0.75 Pain Relevance 0.21
This phenomenon is believed to be produced by a placental opioid-enhancing factor (POEF).
Positive_regulation (enhancing) of factor associated with opioid
2) Confidence 0.40 Published 2000 Journal Physiol. Behav. Section Abstract Doc Link 10978472 Disease Relevance 0.10 Pain Relevance 1.19
Finally, microdialysis sampling has demonstrated in vivo elevation of glial cell line-derived neurotrophic factor following grafting of primed fetal human neural stem cells into brain-injured rats, the first in vivo demonstration of the release of a neurotrophic factor by grafted stem cells.
Positive_regulation (elevation) of factor in brain
3) Confidence 0.39 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18436292 Disease Relevance 0.44 Pain Relevance 0.42
Elevation of the neuroactive cytokine leukemia inhibitory factor following peripheral nerve injury may be a contributory factor to the pathogenesis of neuropathic pain.
Positive_regulation (Elevation) of factor in peripheral nerve associated with leukemia, nervous system injury, neuropathic pain, peripheral nerve injury and cytokine
4) Confidence 0.38 Published 1996 Journal Neuroscience Section Abstract Doc Link 8684613 Disease Relevance 1.23 Pain Relevance 0.69
Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-alpha in vitro in human U138-MG glioblastoma cells.
Positive_regulation (increase) of factor in nerve associated with necrosis, nerve growth factor, glioblastoma and cancer
5) Confidence 0.30 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303935 Disease Relevance 0.72 Pain Relevance 0.30
Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain.
Positive_regulation (upregulation) of factor in sensory neurons associated with neuralgia, nerve growth factor and neuropathic pain
6) Confidence 0.29 Published 2003 Journal Mol. Cell. Neurosci. Section Title Doc Link 12812756 Disease Relevance 0.77 Pain Relevance 1.01
[The biological activity of the transfer factor induced by bacterial antigens].
Positive_regulation (induced) of transfer factor
7) Confidence 0.28 Published 1997 Journal Mikrobiol. Z. Section Title Doc Link 9480022 Disease Relevance 1.17 Pain Relevance 0.08
Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-alpha in vitro in human U138-MG glioblastoma cells.
Positive_regulation (increase) of factor in nerve associated with necrosis, nerve growth factor, glioblastoma and cancer
8) Confidence 0.22 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303935 Disease Relevance 0.72 Pain Relevance 0.30
Cotinine possibly increases the turnover rate of platelet-activating factor (PAF) because it is a potent activator of PAF hydrolase, and it may play a significant role in tobacco-induced arterial thrombosis.
Positive_regulation (activating) of factor in platelet associated with thrombosis
9) Confidence 0.21 Published 1995 Journal Pharmacology Section Abstract Doc Link 7716176 Disease Relevance 0.19 Pain Relevance 0.33
This repeat-binding factor was also shown to be developmentally upregulated specifically in pachytene spermatocytes.
Positive_regulation (upregulated) of factor in spermatocytes
10) Confidence 0.18 Published 2000 Journal Mol. Reprod. Dev. Section Abstract Doc Link 11013429 Disease Relevance 0.08 Pain Relevance 0
Repeated measurements of transfer factor in rabbits: an animal model suitable for evaluation of short-term exposure.
Positive_regulation (measurements) of transfer factor associated with anesthesia
11) Confidence 0.16 Published 1994 Journal Clin Physiol Section Title Doc Link 8149710 Disease Relevance 0 Pain Relevance 0.10
BACKGROUND: Plasma concentrations of hepatocyte growth factor (HGF), a powerful angiogenic growth factor inducible by heparin, increase in thrombus-associated disorders such as myocardial infarction and unstable angina.
Positive_regulation (inducible) of factor in Plasma associated with angina, myocardial infarction and thrombosis
12) Confidence 0.12 Published 2002 Journal Circulation Section Abstract Doc Link 12473563 Disease Relevance 0.37 Pain Relevance 0.10
Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells.
Positive_regulation (increases) of factor in hepatocyte associated with thrombosis
13) Confidence 0.12 Published 2002 Journal Circulation Section Title Doc Link 12473563 Disease Relevance 0.29 Pain Relevance 0.09
Because nerve growth factor (NGF), which is elevated in burn-injured tissue, produces mechanical hyperalgesia and activates protein kinase C (PKC)-epsilon, a key mediator in inflammatory and neuropathic pain, we used this model to evaluate the role of the NGF receptor, tyrosine-receptor kinase A (TrkA), and PKC-epsilon in burn-induced primary mechanical hyperalgesia.
Positive_regulation (elevated) of factor in nerve associated with kinase c, hyperalgesia, inflammation, nerve growth factor, burns and neuropathic pain
14) Confidence 0.11 Published 2006 Journal J Pain Section Abstract Doc Link 17157774 Disease Relevance 1.62 Pain Relevance 1.24
This study was designed to identify brain regions that demonstrate specific induction of the IEG c-fos, a component of the AP-1 transcription factor, in response to acute morphine, and to contrast this induction with the stressful effects of the injection itself.
Positive_regulation (induction) of factor in brain associated with morphine
15) Confidence 0.10 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673793 Disease Relevance 0 Pain Relevance 0.60
We propose that the release of ACTH and the suppression of growth hormone release following urethane anaesthesia is a result of activation of central NNA and suggest that the hormonal responses are mediated via hypothalamic noradrenergic facilitation of corticotrophin releasing factor and somatostatin release to the anterior pituitary.
Positive_regulation (facilitation) of factor in anterior pituitary associated with somatostatin
16) Confidence 0.10 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 2855198 Disease Relevance 0 Pain Relevance 0.61
We propose that the release of ACTH and the suppression of growth hormone release following urethane anaesthesia is a result of activation of central NNA and suggest that the hormonal responses are mediated via hypothalamic noradrenergic facilitation of corticotrophin releasing factor and somatostatin release to the anterior pituitary.
Positive_regulation (facilitation) of factor in anterior pituitary associated with somatostatin
17) Confidence 0.10 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 3274655 Disease Relevance 0 Pain Relevance 0.61
Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-L-histidyl-L-lysine, for enhancement of function of hepatoma cells.
Positive_regulation (enhancement) of factor associated with hepatocellular cancer
18) Confidence 0.09 Published 1999 Journal J. Biosci. Bioeng. Section Title Doc Link 16232640 Disease Relevance 0.32 Pain Relevance 0.08
The inactivation of rat atrial natriuretic factor (ANF) was studied using a bioassay, ANF-stimulated guanylate cyclase activity.
Positive_regulation (inactivation) of factor associated with natriuresis
19) Confidence 0.08 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2973321 Disease Relevance 0.17 Pain Relevance 0.09
The effects of N6-cyclohexyladenosine (0.1 mg/kg) and L-N6-phenylisopropyladenosine (0.1 mg/kg) were completely blocked in animals pretreated with dexamethasone (3 x 1 mg/kg), as well as in animals with a pharmacological blockade of the release of hypothalamic corticotropin-releasing factor induced by chloropromazine (10 mg/kg), morphine (20 mg/kg) and nembutal (25 mg/kg), whereas the corticosterone response to 5'-N-ethylcarboxamidoadenosine (0.01 mg/kg) was blocked in dexamethasone-pretreated rats only.
Positive_regulation (induced) of factor associated with dexamethasone and morphine
20) Confidence 0.08 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1471459 Disease Relevance 0 Pain Relevance 0.35

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