INT50970

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 51
Total Number 53
Disease Relevance 29.38
Pain Relevance 22.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 7
neuronal 3
nerve 2
Sensory neurons 1
quadriceps 1
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 551 100.00 Very High Very High Very High
Trk A 34 100.00 Very High Very High Very High
Kappa opioid receptor 7 99.96 Very High Very High Very High
Osteoarthritis 62 99.90 Very High Very High Very High
nociceptor 149 99.86 Very High Very High Very High
antinociception 4 99.80 Very High Very High Very High
Neuropeptide 51 99.76 Very High Very High Very High
analgesia 58 99.44 Very High Very High Very High
Hsan 8 99.26 Very High Very High Very High
epidural 72 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 16 99.92 Very High Very High Very High
Knee Osteoarthritis 18 99.90 Very High Very High Very High
Toxicity 64 99.80 Very High Very High Very High
Pulmonary Disease 108 99.72 Very High Very High Very High
Osteoarthritis 54 99.56 Very High Very High Very High
Hemorrhage 59 99.36 Very High Very High Very High
Heart Rate Under Development 120 99.26 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 13 99.26 Very High Very High Very High
Neuropathic Pain 112 99.16 Very High Very High Very High
Pain 285 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide donors also contribute to neuronal survival through transactivation of TrkA [113-115].
Positive_regulation (transactivation) of TrkA in neuronal
1) Confidence 0.57 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.34 Pain Relevance 0.42
We reported that the mechanical allodynia in db/db mice is concordantly associated increased NGF/Trk A receptor signaling in DRG neurons.
Positive_regulation (increased) of Trk A in neurons associated with nerve growth factor, allodynia and trk a
2) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 2.03 Pain Relevance 1.43
Sensory neurons (nociceptors) that require NGF/trkA signaling for establishing and maintaining cutaneous innervation during development do not require NGF for central targeting [127].
Positive_regulation (require) of trkA in Sensory neurons associated with nerve growth factor and nociceptor
3) Confidence 0.49 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.13 Pain Relevance 0.35
Although secondary osteoarthritis is a relatively rare indication for TKR, it accounted for 15% of operations in patients aged ?
Positive_regulation (indication) of TKR associated with osteoarthritis
4) Confidence 0.48 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917562 Disease Relevance 0.47 Pain Relevance 0.20
Furthermore, this effect involved phosphorylation of cAMP response element-binding protein and activation of the tropomyosin-related kinase (Trk) receptors.
Positive_regulation (activation) of Trk
5) Confidence 0.47 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.55 Pain Relevance 0.43
The timing of neurotrophin/Trk signalling requirements and the cell types affected by the neurotrophin deficiencies have been well studied [26].
Positive_regulation (requirements) of Trk
6) Confidence 0.46 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.46 Pain Relevance 0.03
According to Puntambekar and Mukherjea, the p38-mediated TRPV1 upregulation is secondary to activation of the Trk A receptor and its downstream RAC1/NADPH oxidase pathway [31].
Positive_regulation (activation) of Trk A associated with trk a
7) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.69 Pain Relevance 1.10
In a randomized, double-blind fashion, 36 patients undergoing TKR received either femoral, sciatic-femoral, or sham nerve blocks after a standardized spinal anesthetic.
Positive_regulation (undergoing) of TKR in nerve
8) Confidence 0.40 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9661553 Disease Relevance 0.40 Pain Relevance 1.13
The aim of this study was to compare the results in patients having a quadriceps sparing total knee replacement (TKR) with those undergoing a standard TKR at a minimum follow-up of two years.
Positive_regulation (undergoing) of TKR in quadriceps
9) Confidence 0.40 Published 2006 Journal J Bone Joint Surg Br Section Abstract Doc Link 17075088 Disease Relevance 0.08 Pain Relevance 0.08
Using the Runx1-conditional knockout mouse, it was shown that Runx1 is dispensable for the de novo induction of TrkA [34].
Positive_regulation (induction) of TrkA associated with targeted disruption
10) Confidence 0.40 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.90 Pain Relevance 0.24
One possible explanation is that the minimal enhancer of trkA, which Runx1 regulates [35], may not be required for the de novo induction of trkA expression [36].
Positive_regulation (enhancer) of trkA
11) Confidence 0.40 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.64 Pain Relevance 0.29
CONCLUSION: Based on the extent of SP and trkA co-expression in airway-specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA-mediated SP induction to mediate neurogenic airway inflammation.


Positive_regulation (induction) of trkA in neurons
12) Confidence 0.40 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
Activation of G-protein coupled receptors by adenosine, or pituitary adenylate cyclase activating peptide (PACAP), also leads to transactivation of TrkA, stimulation of downstream signaling, and neuroprotection [116,117].
Positive_regulation (transactivation) of TrkA in pituitary associated with adenocard
13) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.32 Pain Relevance 0.38
Dose-dependent toxicity was also measured for this library and TrkA activation and toxicity were modeled mathematically using quantitative structure activity relationship (QSAR) models.
Positive_regulation (activation) of TrkA associated with toxicity
14) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.38 Pain Relevance 0.28
There was no correlation between activation of TrkA and cellular viability, suggesting that toxicity is not dependent on agonist activity.
Positive_regulation (activation) of TrkA associated with toxicity and agonist
15) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.29 Pain Relevance 0.32
It has also been shown that NGF lowers the threshold and enhances the response of nociceptors to mechanical stimuli [21], suggesting that NGF activation of TrkA may play a role in activating/sensitizing mechanotransducers expressed by sensory nerve fibers.
Positive_regulation (activation) of TrkA in sensory nerve associated with nerve growth factor and nociceptor
16) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.44 Pain Relevance 1.20
These data suggest that local modulation of nerve fibers must be involved, as transport of the NGF/TrkA from the nerve terminals in the femoral fracture site to the cell bodies of sensory neurons that innervate the femur (which are located in the L1-L3 ganglia) would be expected to take significantly longer than 8 hours [24].
Positive_regulation (transport) of TrkA in femur associated with nerve growth factor and femoral fractures
17) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.48 Pain Relevance 0.91
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
Positive_regulation (induction) of trkA in neurons associated with repression
18) Confidence 0.37 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.65 Pain Relevance 0.28
Previous studies suggest the following model for Trk activation: in the ligand-unbound state, the activation loop blocks access of substrates to the active site of the kinase domain.
Positive_regulation (activation) of Trk
19) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Thus, since bone appears to lack the redundancy of the C-fiber non-peptidergic IB4/RET+ nerve fibers that are present in skin [10], blocking TrkA activation may be particularly efficacious in relieving bone pain vs. skin pain.


Positive_regulation (activation) of TrkA in skin associated with pain and c fibre
20) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.90 Pain Relevance 1.06

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