INT50971

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 15
Speculated 3
Reported most in Abstract
Documents 180
Total Number 190
Disease Relevance 73.52
Pain Relevance 62.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 47
nociceptors 18
sensory neurons 7
dorsal root ganglia 7
nerve 6
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 2470 100.00 Very High Very High Very High
Nerve growth factor 1562 100.00 Very High Very High Very High
dorsal root ganglion 879 100.00 Very High Very High Very High
Calcitonin gene-related peptide 624 100.00 Very High Very High Very High
substance P 364 100.00 Very High Very High Very High
trigeminal ganglion 2446 99.96 Very High Very High Very High
Neuropeptide 474 99.92 Very High Very High Very High
Osteoarthritis 152 99.90 Very High Very High Very High
calcitonin gene related peptide 356 99.80 Very High Very High Very High
Peripheral nervous system 66 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5336 100.00 Very High Very High Very High
Nociception 758 100.00 Very High Very High Very High
Repression 255 100.00 Very High Very High Very High
Knee Osteoarthritis 20 99.90 Very High Very High Very High
Targeted Disruption 2187 99.88 Very High Very High Very High
Disease 1229 99.84 Very High Very High Very High
Cancer 550 99.66 Very High Very High Very High
Toxicity 102 99.66 Very High Very High Very High
Osteoarthritis 75 99.56 Very High Very High Very High
Aging 69 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Delayed migration to the DRGs was suggested by ectopic cells expressing tyrosine receptor kinase A (TrkA) and TrkC, neurotrophin receptors required by DRG sensory neuron development.
Gene_expression (expressing) of TrkA in DRGs
1) Confidence 0.75 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.28
This proportion is considerably lower than that observed in Dorsal Root Ganglion nociceptors, in which approximately 80% in neonates and approximately 40% in adults express trkA (Molliver and Snider, J.
Gene_expression (express) of trkA in nociceptors associated with ganglion cysts and nociceptor
2) Confidence 0.75 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.25 Pain Relevance 0.54
Immunocytochemistry using polyclonal anti-trkA antibodies confirmed this result and extended it to show low levels of trkA protein expression in afferents labeled from the cornea.
Gene_expression (expression) of trkA in cornea
3) Confidence 0.75 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.22 Pain Relevance 0.51
Differences in neurotrophic requirements may be related to differences in target tissues, in embryonic origin of some trigeminal ganglion cells, or in the timing of down-regulation of trkA expression in trigeminal ganglion cells.
Gene_expression (expression) of trkA in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
4) Confidence 0.75 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.32 Pain Relevance 0.58
The identity of these non-TrkA expressing, NGF-dependent neurons has not been established.
Gene_expression (expressing) of TrkA in neurons
5) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.75 Pain Relevance 0.41
These neurons express the signaling receptor for NGF, TrkA.
Gene_expression (express) of TrkA in neurons
6) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.60 Pain Relevance 0.29
These neurons must either depend on NGF via a novel, indirect mechanism or alternatively, downregulate TrkA expression during development.
Gene_expression (expression) of TrkA in neurons
7) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.62 Pain Relevance 0.36
We show here that most of these BSI-binding DRG neurons do not express TrkA in adult mice.
Neg (not) Gene_expression (express) of TrkA in neurons associated with dorsal root ganglion
8) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.76 Pain Relevance 0.43
There is a major discrepancy, however, between the percentage of DRG neurons which require NGF for survival (70-85%) and percentage of DRG neurons expressing TrkA receptors (40-50%).
Gene_expression (expressing) of TrkA in neurons associated with dorsal root ganglion
9) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.74 Pain Relevance 0.40
BSI-binding DRG cells are thus the first identified neuronal population in which cells do not express TrkA in maturity, but require NGF/TrkA signaling for survival during embryonic development.
Neg (not) Gene_expression (express) of TrkA in neuronal associated with dorsal root ganglion
10) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.69 Pain Relevance 0.40
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
Gene_expression (expressing) of TrkA in neurons associated with neuropeptide
11) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Title Doc Link 7666178 Disease Relevance 0.66 Pain Relevance 0.50
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Gene_expression (expressing) of TrkA in sensory neurons
12) Confidence 0.71 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.31 Pain Relevance 0
At P0, in order to confirm the loss of sensory neurons in Ndn-KO DRGs, we compared the expression of TrkA in L1 DRGs specifically, between mutant and wild type neonates (WT: 2050 (1700, 2310), n = 3; Ndn KO: 1243 (1065, 1680), n = 3).
Gene_expression (expression) of TrkA in sensory neurons
13) Confidence 0.71 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.19 Pain Relevance 0
Later in development and in adult, we showed that PV-fibers and CGRP-fibers that express TrkC and TrkA respectively are correctly patterned; however we detected a reduction in the number of fibers.
Gene_expression (express) of TrkA associated with nociception
14) Confidence 0.71 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.26 Pain Relevance 0.12
METHODS: Using retrograde neuronal tracing in combination with double-labelling immunohistochemistry, SP, trkA- and TRPV1-receptor expression was examined in airway-specific sensory neurons of BALB/c mice before and after NGF treatment.
Gene_expression (expression) of trkA in sensory neurons
15) Confidence 0.66 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
RESULTS: NGF injected into the lower airway was able to induce SP (13.0+/-2.03% vs. 5.9+/-0.33%) and trkA expression (78+/-2.66% vs. 60+/-2.11%) in larger diameter (>25 microm), capsaicin-insensitive and trkA-positive vagal sensory neurons that were retrograde-labelled with Fast Blue dye from the main stem bronchi.
Gene_expression (expression) of trkA in stem
16) Confidence 0.66 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
Sensory neurons (nociceptors) that require NGF/trkA signaling for establishing and maintaining cutaneous innervation during development do not require NGF for central targeting [127].
Gene_expression (/) of trkA in Sensory neurons associated with nerve growth factor and nociceptor
17) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.13 Pain Relevance 0.35
Similar enhancements were observed with NT-3 and NT-4 and with NGF despite the fact that hippocampal neurons lack TrkA receptors.
Neg (lack) Gene_expression (lack) of TrkA in neurons associated with nerve growth factor
18) Confidence 0.65 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9356388 Disease Relevance 0 Pain Relevance 0.29
Mechanistically, the great majority of sensory fibers that innervate the bone are CGRP/TrkA expressing fibers, and if the sensitization and activation of these fibers is blocked by anti-NGF therapy there would not be another population of nociceptors, such as the non-peptidergic IB4/RET-IR nerve fibers, to take their place in signaling nociceptive events.
Gene_expression (expressing) of TrkA in nerve associated with nociception, nerve growth factor and nociceptor
19) Confidence 0.65 Published 2005 Journal Pain Section Abstract Doc Link 15836976 Disease Relevance 1.14 Pain Relevance 0.94
Most trkA-positive cells that were CGRP-negative were medium-to-large diameter, while most of those that were CGRP-positive but trkA-negative were small diameter.
Neg (negative) Gene_expression (negative) of trkA
20) Confidence 0.65 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.22 Pain Relevance 0.68

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