INT50973

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Context Info
Confidence 0.56
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 11.12
Pain Relevance 7.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 24
trigeminal ganglion 4
sensory neurons 2
nociceptors 2
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 306 99.92 Very High Very High Very High
Neuropeptide 58 99.92 Very High Very High Very High
trigeminal ganglion 458 99.84 Very High Very High Very High
Nerve growth factor 214 99.08 Very High Very High Very High
dorsal root ganglion 64 98.44 Very High Very High Very High
Calcitonin gene-related peptide 90 92.96 High High
Central nervous system 21 91.88 High High
mu opioid receptor 24 88.92 High High
Dorsal horn 5 87.56 High High
calcitonin gene related peptide 68 84.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 90 100.00 Very High Very High Very High
Ganglion Cysts 852 99.68 Very High Very High Very High
Aging 11 99.62 Very High Very High Very High
Targeted Disruption 348 99.60 Very High Very High Very High
Disease 283 99.58 Very High Very High Very High
Death 231 98.96 Very High Very High Very High
Neurodegenerative Disease 108 98.16 Very High Very High Very High
Apoptosis 377 95.44 Very High Very High Very High
Sarcoma 8 90.44 High High
Cancer 60 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in neurotrophic requirements may be related to differences in target tissues, in embryonic origin of some trigeminal ganglion cells, or in the timing of down-regulation of trkA expression in trigeminal ganglion cells.
Negative_regulation (down) of Gene_expression (expression) of trkA in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.56 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.32 Pain Relevance 0.59
These neurons must either depend on NGF via a novel, indirect mechanism or alternatively, downregulate TrkA expression during development.
Negative_regulation (downregulate) of Gene_expression (expression) of TrkA in neurons
2) Confidence 0.54 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666178 Disease Relevance 0.62 Pain Relevance 0.36
TrkA expression is reduced, but p75NTR amounts are unchanged in AD [55,56].
Negative_regulation (reduced) of Gene_expression (expression) of TrkA associated with disease
3) Confidence 0.48 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.77 Pain Relevance 0.49
Differences in neurotrophic requirements may be related to differences in target tissues, in embryonic origin of some trigeminal ganglion cells, or in the timing of down-regulation of trkA expression in trigeminal ganglion cells.
Negative_regulation (regulation) of Gene_expression (expression) of trkA in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
4) Confidence 0.42 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11794733 Disease Relevance 0.32 Pain Relevance 0.59
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
Negative_regulation (lost) of Gene_expression (expressing) of TrkA in neurons associated with neuropeptide
5) Confidence 0.39 Published 1995 Journal J. Neurosci. Section Title Doc Link 7666178 Disease Relevance 0.67 Pain Relevance 0.51
With this in mind, we report a loss of 27% of TrkA expressing cells at E13.5 and a 40% loss of TrkA expressing cells at P0, a substantial reduction between E13.5 and P0.
Negative_regulation (loss) of Gene_expression (expressing) of TrkA associated with nociception
6) Confidence 0.39 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.65 Pain Relevance 0.03
The abrogation of Necdin results in a relatively selective loss of neurons in DRGs: TrkA and TrkC cell populations are reduced but not TrkB population.
Neg (not) Negative_regulation (reduced) of Neg (not) Gene_expression (population) of TrkA in neurons associated with nociception
7) Confidence 0.39 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.52 Pain Relevance 0
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Spec (partial) Negative_regulation (loss) of Gene_expression (expressing) of TrkA in sensory neurons
8) Confidence 0.39 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.31 Pain Relevance 0
Early expression of TrkA is normal in the Brn3a knockouts (Figure 5A, B) but begins to decline at mid-gestation and it is markedly reduced by birth in the TG (Figure 2N) [18] and in the DRG [11].
Negative_regulation (decline) of Gene_expression (expression) of TrkA associated with trigeminal ganglion
9) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.72 Pain Relevance 0.50
These changes are accompanied by expanded expression of TrkB in neurons that abnormally express multiple Trks, followed by the loss of TrkC and TrkA expression.
Negative_regulation (loss) of Gene_expression (expression) of TrkA in neurons
10) Confidence 0.32 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 0.33
Brn3a-/- TG neurons also exhibit abnormal persistence of the co-expression of TrkA and TrkB, and subsequent loss of TrkA expression.
Negative_regulation (loss) of Gene_expression (expression) of TrkA in neurons associated with trigeminal ganglion
11) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.71 Pain Relevance 0.42
Runx1-mediated effects are not sufficient to explain the loss of TrkA expression in the Brn3a-/- TG.
Negative_regulation (loss) of Gene_expression (expression) of TrkA associated with trigeminal ganglion
12) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.66 Pain Relevance 0.49
Treatment with Trk inhibitor (ARRY-470) therapy
Negative_regulation (inhibitor) of Gene_expression (therapy) of Trk
13) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.40 Pain Relevance 0.26
However, ret mutation compromises, but does not prevent, the loss of trkA expression in a subset of DRG neurons.
Negative_regulation (prevent) of Gene_expression (expression) of trkA in neurons
14) Confidence 0.24 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.42
In perinatal development, nociceptors further differentiate into peptidergic and non-peptidergic phenotypes, the latter being distinguished by downregulation of TrkA and expression of Ret [2,3].
Negative_regulation (downregulation) of Gene_expression (expression) of TrkA in nociceptors associated with nociceptor
15) Confidence 0.24 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.52
The number of TrkA+ neurons was markedly reduced at P0 (Figure 2M, N), consistent with previous reports [18,39].
Negative_regulation (reduced) of Gene_expression (neurons) of TrkA in neurons
16) Confidence 0.24 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.71 Pain Relevance 0.43
In the same study, siRNA knock-down of early Runx1 expression as well as overexpression of a general dominant-negative Runx protein was shown to down-regulate TrkA expression and cause the subsequent death of the neurons.
Negative_regulation (regulate) of Gene_expression (expression) of TrkA in neurons associated with targeted disruption and death
17) Confidence 0.22 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.61 Pain Relevance 0.17
There seems to be conflicting data with regards to an early role of Runx1 in the development of nociceptive sensory neurons since there is no loss of TrkA+ neurons in mice that lack Runx1 expression in DRG cells [26, 44].
Neg (no) Negative_regulation (loss) of Gene_expression (neurons) of TrkA in neurons associated with nociception and dorsal root ganglion
18) Confidence 0.22 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.63 Pain Relevance 0.31
However, ret mutation compromises, but does not prevent, the loss of trkA expression in a subset of DRG neurons.
Negative_regulation (loss) of Gene_expression (expression) of trkA in neurons
19) Confidence 0.18 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.42
Many but not all ret-positive cells lose trkA expression postnataly and bind the lectin, Griffonia simplicifolia isolectin B4 Postnatally, neurons coexpressing ret and trkA, as analysed by double ISH, undergo trkA extinction, which appears to be complete at P14 (Luo et al. 2007).
Neg (not) Negative_regulation (lose) of Gene_expression (expression) of trkA in neurons
20) Confidence 0.18 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.07

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