INT50975

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.64
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
spinal cord 2
spinal 1
eye 1
paw 1
EM-2 1
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 168 100.00 Very High Very High Very High
Dynorphin 80 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
alcohol 34 99.98 Very High Very High Very High
Spinal cord 28 99.68 Very High Very High Very High
Inflammation 49 99.60 Very High Very High Very High
depression 1 99.40 Very High Very High Very High
antinociception 108 99.16 Very High Very High Very High
Analgesic 184 95.96 Very High Very High Very High
analgesia 83 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 86 99.60 Very High Very High Very High
Depression 1 99.40 Very High Very High Very High
Pressure And Volume Under Development 65 96.92 Very High Very High Very High
Pain 60 93.92 High High
Nociception 22 89.64 High High
Parkinson's Disease 4 89.56 High High
Peripheral Arterial Disease 2 85.44 High High
Sprains And Strains 2 79.52 Quite High
Granuloma 22 74.88 Quite High
Neuroblastoma 1 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiinflammatory activity of alcohol extract of ME was evaluated using acute (carrageenan) and sub acute (cotton pellet) models of inflammation.
Localization (extract) of ME associated with inflammation and alcohol
1) Confidence 0.65 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC3013566 Disease Relevance 0.88 Pain Relevance 0.69
In acute inflammation model, the alcohol extract of ME at a dose of 200 mg/kg showed maximum inhibition of carrageenan-induced paw oedema at 3 rd h (30.9%) with a mean paw edema volume of 0.94±0.05 ml and diclofenac showed 36.8 % inhibition (0.86±0.027 ml) of oedema at 3 rd h when compared to control 1.36±0.014 (Table 1).
Localization (extract) of ME in paw associated with pressure and volume under development, inflammation, diclofenac and alcohol
2) Confidence 0.65 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC3013566 Disease Relevance 0.54 Pain Relevance 0.31
In cortex, the change in NE metabolism appears to cause a decrease of ME release and thereby a depression of PE synthesis.
Localization (release) of ME in cortex associated with depression and enkephalin
3) Confidence 0.51 Published 1993 Journal Neurochem. Int. Section Abstract Doc Link 8439770 Disease Relevance 0.39 Pain Relevance 0.62
In contrast to earlier studies using cats, previous reports using rats showed that ME after eye-specific segregation did not alter the distribution patterns of RGC axons in the dLGN [19], [20].
Localization (segregation) of ME in eye
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.08 Pain Relevance 0
Further research implied that the antinociception induced by EM-2 might be mediated by the release of Dyn A1–17 and ME, which subsequently acted on KORs and DORs to produce antinociception (Tseng et al., 2000; Sakurada et al., 2001).
Localization (release) of ME in EM-2 associated with antinociception and dynorphin
5) Confidence 0.11 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.27 Pain Relevance 0.62
Right mouse ears were topically treated 1 X/d for 5 d with 20 wt% P. nagi ME or intact oil (4 ?
Localization (oil) of ME in ears
6) Confidence 0.10 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.29 Pain Relevance 0.03
-EP was attributed to the release of ME in the spinal cord.
Localization (release) of ME in spinal cord associated with spinal cord
7) Confidence 0.10 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.63
To determine the cellular sites for DOR-mediated actions, we examined the ultrastructural localization of DOR and Met5-enkephalin (ME) in the spinal cord by combining immunoperoxidase and immunogold-silver labeling for antibodies against DOR and ME, respectively.
Spec (examined) Localization (localization) of ME in spinal cord associated with enkephalin, opioid receptor and spinal cord
8) Confidence 0.09 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666182 Disease Relevance 0.20 Pain Relevance 1.29
-EP injected into the fourth ventricle could increase immunoreactive ME in the spinal perfusate in urethane-anesthetized rats; furthermore, Bestatin increased the amount of immunoreactive ME released by ?
Localization (released) of ME in spinal
9) Confidence 0.09 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.76
-EP was mediated by release of ME.
Localization (release) of ME
10) Confidence 0.09 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.75

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