INT5098

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 70
Total Number 71
Disease Relevance 3.56
Pain Relevance 51.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
spinal cord 6
stomach 6
pancreatic islets 4
blood 4
plasma 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 456 100.00 Very High Very High Very High
Enkephalin 113 100.00 Very High Very High Very High
qutenza 50 100.00 Very High Very High Very High
Glutamate 36 100.00 Very High Very High Very High
agonist 29 100.00 Very High Very High Very High
Calcitonin gene-related peptide 26 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
orphanin 8 100.00 Very High Very High Very High
excitatory amino acid 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 3 100.00 Very High Very High Very High
Hyperalgesia 3 99.56 Very High Very High Very High
Nociception 13 99.04 Very High Very High Very High
Impaired Glucose Tolerance 6 97.44 Very High Very High Very High
Cancer 16 95.12 Very High Very High Very High
Pancreatic Cancer 70 94.04 High High
Nervous System Injury 1 91.88 High High
INFLAMMATION 4 90.44 High High
Neuropathic Pain 3 90.28 High High
Pressure And Volume Under Development 2 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamate-induced somatostatin release was not blocked by tetrodotoxin (1 microM) suggesting that tetrodotoxin-sensitive sodium-dependent action potentials are not involved in this effect.
Negative_regulation (blocked) of Localization (release) of somatostatin associated with action potential, tetrodotoxin, glutamate and somatostatin
1) Confidence 0.58 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 1.08
JYL1421 concentration-dependently (0.1-2 microM) inhibited capsaicin-evoked substance P, calcitonin gene-related peptide and somatostatin release from isolated tracheae, while only 2 microM resulted in a significant inhibition of electrically induced neuropeptide release.
Negative_regulation (inhibited) of Localization (release) of somatostatin associated with qutenza, somatostatin, neuropeptide release, calcitonin gene-related peptide and substance p
2) Confidence 0.57 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15978575 Disease Relevance 0.37 Pain Relevance 0.87
Decreases in pituitary GH or increases in somatostatin secretion would not explain this decreased response because the GH response of MRZ 2549, an opiate agonist, was unchanged by GH-RP-6 pretreatment.
Negative_regulation (Decreases) of Localization (secretion) of somatostatin in pituitary associated with agonist, somatostatin and opiate
3) Confidence 0.57 Published 1985 Journal Endocrinology Section Abstract Doc Link 4029086 Disease Relevance 0 Pain Relevance 0.19
The results indicate that the alpha-adrenergic influence on the secretion of GH is mediated not by inhibition of somatostatin release but rather by effects on the release of a GHRF.
Negative_regulation (inhibition) of Localization (release) of somatostatin associated with somatostatin
4) Confidence 0.57 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.25
The aim of this study was to investigate whether central alpha 2-adrenergic pathways act, in rats, by inhibiting somatostatin (SS) release, as it has been postulated to occur in other species.
Spec (whether) Negative_regulation (inhibiting) of Localization (release) of somatostatin associated with somatostatin
5) Confidence 0.57 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 7901787 Disease Relevance 0 Pain Relevance 0.37
The release of somatostatin induced by the excitatory amino acid agonists was not blocked by tetrodotoxin (1 microM), a result suggesting that tetrodotoxin-sensitive, sodium-dependent action potentials are not involved in the effect.
Negative_regulation (blocked) of Localization (release) of somatostatin associated with action potential, tetrodotoxin, agonist, somatostatin and excitatory amino acid
6) Confidence 0.56 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2570126 Disease Relevance 0 Pain Relevance 0.99
CGS 19755, a highly selective N-methyl-D-aspartate (NMDA) receptor antagonist, significantly reduced tonic somatostatin secretion whereas it was strongly increased by picrotoxin and bicuculline, two GABAA antagonists.
Negative_regulation (reduced) of Localization (secretion) of somatostatin associated with antagonist and somatostatin
7) Confidence 0.56 Published 1992 Journal Endocrinology Section Abstract Doc Link 1346378 Disease Relevance 0 Pain Relevance 1.29
Ip injected CGS 19755 (an antagonist that can freely permeate the blood-brain barrier) completely blocked the peak secretion of somatostatin observed after ip picrotoxin administration, whereas there was no significant effect when it was injected alone.
Negative_regulation (blocked) of Localization (secretion) of somatostatin in blood associated with antagonist and somatostatin
8) Confidence 0.56 Published 1992 Journal Endocrinology Section Abstract Doc Link 1346378 Disease Relevance 0 Pain Relevance 1.09
Opioid peptides are potent inhibitors of gastric somatostatin secretion.
Negative_regulation (inhibitors) of Localization (secretion) of somatostatin associated with somatostatin and opioid
9) Confidence 0.56 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982463 Disease Relevance 0 Pain Relevance 0.83
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Negative_regulation (inhibition) of Localization (secretion) of somatostatin in stomach associated with analgesic, somatostatin and opioid
10) Confidence 0.56 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7982463 Disease Relevance 0 Pain Relevance 1.36
Anantin alone inhibited somatostatin secretion by 18+/-3% (P<0.005), implying that endogenous ANP, acting via the NPR-A receptor, stimulates somatostatin secretion.
Negative_regulation (inhibited) of Localization (secretion) of somatostatin associated with somatostatin
11) Confidence 0.56 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.15 Pain Relevance 0.67
Pretreatment with phentolamine (1 mg kg-1) significantly increased and pretreatment with clonidine (60 micrograms kg-1 h-1) significantly decreased somatostatin release caused by vagal stimulation, whereas gastrin levels remained largely unchanged.
Negative_regulation (decreased) of Localization (release) of somatostatin associated with somatostatin and clonidine
12) Confidence 0.55 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1350163 Disease Relevance 0 Pain Relevance 0.51
Naloxone (10(-6) M) significantly inhibited basal somatostatin secretion in the presence and absence of atropine and of hexamethonium, whereas basal GRP and gastrin secretion was not affected by naloxone.
Negative_regulation (inhibited) of Localization (secretion) of somatostatin associated with somatostatin and narcan
13) Confidence 0.54 Published 1987 Journal Life Sci. Section Abstract Doc Link 2889122 Disease Relevance 0 Pain Relevance 0.67
Field stimulation at 30 V, 10 Hz, 4 ms caused a sixfold increase in gastrin and a twofold increase in somatostatin secretion that were nearly abolished by tetrodotoxin (85-89% inhibition).
Negative_regulation (abolished) of Localization (secretion) of somatostatin associated with tetrodotoxin and somatostatin
14) Confidence 0.51 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.43
Atropine inhibited bombesin-induced somatostatin release to the same extent as tetrodotoxin, indicating that cholinergic pathways mediated bombesin-induced somatostatin release.
Negative_regulation (inhibited) of Localization (release) of somatostatin associated with tetrodotoxin and somatostatin
15) Confidence 0.51 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1976561 Disease Relevance 0 Pain Relevance 0.82
Coadministration of gastrin antiserum and tetrodotoxin attenuated bombesin-stimulated somatostatin release.
Negative_regulation (attenuated) of Localization (release) of somatostatin associated with tetrodotoxin and somatostatin
16) Confidence 0.51 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1976561 Disease Relevance 0.06 Pain Relevance 0.94
gamma-Aminobutyric acid inhibits the potassium-stimulated release of somatostatin from rat spinal cord slices.
Negative_regulation (inhibits) of Localization (release) of somatostatin in spinal cord associated with somatostatin and spinal cord
17) Confidence 0.50 Published 1990 Journal Brain Res. Section Title Doc Link 1967972 Disease Relevance 0.18 Pain Relevance 0.82
Capsaicin administration inhibited the stimulated gastrin and histamine secretion and reversed the suppression of somatostatin secretion mediated by vagal stimulation.
Negative_regulation (reversed) of Localization (secretion) of somatostatin
18) Confidence 0.48 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19296048 Disease Relevance 0 Pain Relevance 0
However, capsaicin had no effect on stimulated gastrin secretion, suppression of somatostatin secretion, or stimulated histamine secretion because of bethanecol.
Negative_regulation (suppression) of Localization (secretion) of somatostatin
19) Confidence 0.48 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19296048 Disease Relevance 0 Pain Relevance 0
The selective bombesin/gastrin-releasing peptide (GRP) antagonist [Leu13-psi(CH2NH)-Leu14]-bombesin partly inhibited the gastrin response (65%) and caused a further decrease in somatostatin secretion.
Negative_regulation (decrease) of Localization (secretion) of somatostatin associated with antagonist and somatostatin
20) Confidence 0.44 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.66

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