INT50990

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Context Info
Confidence 0.37
First Reported 1993
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.71
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
CPu 4
CPU 1
brain 1
brainstem 1
VMN 1
Cpb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 110 100.00 Very High Very High Very High
opioid receptor 30 100.00 Very High Very High Very High
Central grey 28 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
cocaine 6 100.00 Very High Very High Very High
Nucleus accumbens 78 99.88 Very High Very High Very High
medulla 1 99.72 Very High Very High Very High
antagonist 6 99.34 Very High Very High Very High
gABA 28 99.00 Very High Very High Very High
withdrawal 9 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 29 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
Myocardial Infarction 24 92.72 High High
Depression 6 88.84 High High
Angina 56 87.24 High High
Cognitive Disorder 29 86.88 High High
Convulsion 1 85.04 High High
Nociception 5 84.48 Quite High
Syndrome 2 77.16 Quite High
INFLAMMATION 2 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A random effects model was used to estimate the effect of CPU care compared to control hospitals, after adjusting for baseline difference between CPU and control hospitals.
Regulation (effect) of CPU
1) Confidence 0.37 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2527313 Disease Relevance 0.57 Pain Relevance 0.20
Thus evidence, which cannot be incorporated in the economic model, leads us to believe that introducing CPU care may increase health service costs without any corresponding evidence that it will improve outcomes.
Regulation (introducing) of CPU
2) Confidence 0.37 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2527313 Disease Relevance 0.28 Pain Relevance 0.28
The addition of nipecotic acid (0.5 mM), a GABA uptake blocker, increased basal extracellular GABA levels 6-15-fold in the intact CPu, while GABA overflow in either the acute or chronic lesioned CPu was not significantly altered.
Neg (not) Regulation (altered) of CPu in CPu associated with gaba
3) Confidence 0.24 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348317 Disease Relevance 0 Pain Relevance 0.72
Veratridine administered at 75 microM, produced a 45-fold increase in GABA overflow in the intact CPu, but failed to produce any effect in the lesioned CPu.
Regulation (effect) of CPu in CPu associated with gaba
4) Confidence 0.24 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348317 Disease Relevance 0 Pain Relevance 0.66
Neither the PL nor IL 6-OHDA lesion had any effect on striatal DA as there were no significant changes in DA levels in the CPu or in either accumbal subterritory.
Neg (no) Regulation (changes) of CPu associated with dopamine
5) Confidence 0.22 Published 2010 Journal Neuroscience Section Body Doc Link PMC2930211 Disease Relevance 0 Pain Relevance 0.46
This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin (PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN).
Regulation (regions) of CPu in brainstem associated with medulla, raphe and withdrawal
6) Confidence 0.22 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.46 Pain Relevance 0.63
The present study examined the effects of NE and the alpha-adrenoceptor antagonist phentolamine on the pain-evoked response of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the CPu of rats.
Spec (examined) Regulation (response) of CPu in CPu associated with pain and antagonist
7) Confidence 0.22 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20553996 Disease Relevance 0.79 Pain Relevance 0.74
In line with previous reports (e.g., Parkinson et al., 2002; Robbins, Giardini, Jones, Reading, & Sahakian, 1990), secondary changes in DA levels were also observed in the mPFC and CPu.
Regulation (changes) of CPu associated with dopamine
8) Confidence 0.20 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.16 Pain Relevance 0.33
By contrast, chronic cocaine did not affect FOS responsiveness to IL-1 beta in the PVN even though the treatment was able to desensitize the FOS responsiveness to acute cocaine in the CPU, nAcc, and LC.
Regulation (responsiveness) of CPU in CPU associated with cocaine
9) Confidence 0.16 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 7668153 Disease Relevance 0 Pain Relevance 0.82
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of CPu in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
10) Confidence 0.16 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0 Pain Relevance 0.48
It is not clear at present, why MORs in this brain region respond differently to mercurial exposure than those in the PAG or CPU.
Neg (not) Regulation (respond) of CPU in brain associated with opioid receptor and central grey
11) Confidence 0.15 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.44 Pain Relevance 0.81
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of CPu in VMN associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
12) Confidence 0.05 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0 Pain Relevance 0.48
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of CPu in CPu associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
13) Confidence 0.05 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0 Pain Relevance 0.48

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