INT50993

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il1b, Fos) extracellular space (Il1b) extracellular region (Il1b)
nucleolus (Fos) nucleus (Fos) DNA binding (Fos)
Anatomy Link Frequency
nucleus 2
Il1b (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 99.84 Very High Very High Very High
narcan 8 99.44 Very High Very High Very High
opioid receptor 7 97.04 Very High Very High Very High
medulla 4 93.76 High High
Catecholamine 2 90.96 High High
cocaine 6 89.84 High High
cytokine 1 89.12 High High
Inflammation 1 88.76 High High
Opioid 1 78.84 Quite High
Endogenous opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Toxocariasis 3 93.40 High High
INFLAMMATION 1 88.76 High High
Infection 1 79.88 Quite High
Disease 1 56.32 Quite High
Injury 1 55.84 Quite High
Stress 1 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with morphine desensitized FOS responsiveness to morphine and IL-1 beta in the PVN since FOS-IR was no longer induced by IL-1 beta or morphine in the PVN after this treatment.
IL-1 beta Positive_regulation (induced) of FOS in PVN associated with morphine
1) Confidence 0.40 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 7668153 Disease Relevance 0.17 Pain Relevance 0.84
Pre-treatment with naloxone methiodide decreased (15%) IL-1beta-induced Fos-immunoreactivity (Fos-IR) in medial parvocellular paraventricular nucleus (mPVN) corticotropin-releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla (VLM) C1 (65%) and nucleus tractus solitarius (NTS) A2 (110%) catecholamine cell groups and area postrema (136%).
IL-1beta-induced Positive_regulation (induced) of Fos-immunoreactivity in nucleus associated with medulla, catecholamine and narcan
2) Confidence 0.00 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15993445 Disease Relevance 0.26 Pain Relevance 1.00

General Comments

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