INT5100

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Context Info
Confidence 0.64
First Reported 1985
Last Reported 2008
Negated 4
Speculated 8
Reported most in Abstract
Documents 100
Total Number 108
Disease Relevance 24.20
Pain Relevance 30.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 13
plasma 8
hypothalamus 3
neurons 3
adenohypophysis 3
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 145 100.00 Very High Very High Very High
Somatostatin 137 100.00 Very High Very High Very High
Morphine 19 100.00 Very High Very High Very High
opiate 19 99.98 Very High Very High Very High
Sumatriptan 40 99.82 Very High Very High Very High
Neurotransmitter 52 99.80 Very High Very High Very High
depression 32 99.80 Very High Very High Very High
Opioid 32 99.80 Very High Very High Very High
qutenza 12 99.72 Very High Very High Very High
narcan 25 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 16 99.96 Very High Very High Very High
Stress 269 99.82 Very High Very High Very High
Obesity 138 99.82 Very High Very High Very High
Depression 34 99.80 Very High Very High Very High
Hypothyroidism 9 99.66 Very High Very High Very High
Immunization 7 99.60 Very High Very High Very High
Aging 45 99.40 Very High Very High Very High
Eating Disorder 50 99.36 Very High Very High Very High
Arthritis 10 98.60 Very High Very High Very High
Starvation 51 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the opposite, the secretion of GH induced by amino acids or clonidine is not preceded by an elevation of plasma GHRH.
Positive_regulation (elevation) of GHRH in plasma associated with clonidine
1) Confidence 0.64 Published 1986 Journal Horm. Res. Section Abstract Doc Link 3093352 Disease Relevance 0.18 Pain Relevance 0.10
An increase of GRF was found in fetuses of both sexes.
Positive_regulation (increase) of GRF
2) Confidence 0.64 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2532147 Disease Relevance 0.70 Pain Relevance 0.25
Thus, to investigate whether the effect of galanin on GH release is the result of either a stimulation of GH-releasing factor (GRF) and/or an inhibition of somatostatin (SRIF) release, we have evaluated the action of galanin on the release of SRIF and GRF from median eminence (ME) fragments in vitro.
Positive_regulation (stimulation) of GRF in median eminence associated with somatostatin
3) Confidence 0.52 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1285434 Disease Relevance 0 Pain Relevance 0.21
Results showed that (a) pituitary responsiveness to GHRH changes throughout the estrous cycle is maximal in diestrus and minimal in proestrus; (b) GHRH stimulated GH secretion in intact and ovariectomized females on days 45, 60 and 90, but not on day 30; (c) the age increase of GH responsiveness to GHRH administration was slightly reduced in animals ovariectomized on day 23; (e) the age increase of pituitary GH content was similar in control and ovariectomized females; and (d) ovariectomy on day 83 reduced pituitary responsiveness to GHRH more effectively than ovariectomy on day 23.
Positive_regulation (responsiveness) of GHRH in pituitary
4) Confidence 0.50 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1834957 Disease Relevance 0 Pain Relevance 0.06
It is suggested that the clonidine-induced GH secretion is modulated by a chain of events which involves primary stimulation of GHRH release resulting in increased GH secretion which, via a negative-feedback mechanism, triggers an enhancement of somatostatin release which ultimately normalizes the system.
Positive_regulation (stimulation) of GHRH associated with somatostatin and clonidine
5) Confidence 0.50 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.57
Hypothalamic GHRH content increased markedly during transition from pre- to mid- and late-pubertal stages (2.05 +/- 0.17 vs 3.13 +/- 0.26 and 3.46 +/- 0.20 ng/hypothalamus respectively, means +/- S.E.M.).
Positive_regulation (increased) of GHRH in hypothalamus
6) Confidence 0.50 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.43
In conclusion, the GH response to GRF is blunted in aging rats.
Positive_regulation (response) of GRF associated with aging
7) Confidence 0.50 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.33 Pain Relevance 0.10
Opiates activate GRF neurons regulating GH release.
Positive_regulation (activate) of GRF in neurons associated with opiate
8) Confidence 0.50 Published 1997 Journal Peptides Section Abstract Doc Link 9149291 Disease Relevance 0 Pain Relevance 0.48
These results indicate that HST calves responded to exogenous GHRF with an abrupt increase in plasma GH, but GH response to GHRF during SRIH infusion was greatly inhibited.
Positive_regulation (response) of GHRF in plasma
9) Confidence 0.50 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2904152 Disease Relevance 0 Pain Relevance 0.08
The effects of growth hormone-releasing factor (GHRF) on growth hormone (GH) secretion were studied in beef calves after hypophysial stalk transection (HST).
Positive_regulation (effects) of GHRF in hypophysial stalk
10) Confidence 0.50 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2904152 Disease Relevance 0 Pain Relevance 0.12
The effects of growth hormone-releasing factor (GHRF) on growth hormone (GH) secretion were studied in beef calves after hypophysial stalk transection (HST).
Positive_regulation (effects) of growth hormone-releasing factor in hypophysial stalk
11) Confidence 0.50 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2904152 Disease Relevance 0 Pain Relevance 0.12
In GX males, however, GH responses to GHRH were enhanced by replacement with estradiol or testosterone, while in GX females, estradiol, but not testosterone, had the same effect.
Positive_regulation (enhanced) of GHRH
12) Confidence 0.50 Published 1988 Journal J. Neural Transm. Section Abstract Doc Link 3126262 Disease Relevance 0 Pain Relevance 0.42
Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats.
Positive_regulation (response) of GH-releasing factor in plasma associated with glutamate
13) Confidence 0.49 Published 1986 Journal Brain Res. Section Title Doc Link 3085872 Disease Relevance 0 Pain Relevance 0.19
Reduction of somatostatin caused enhanced GH response to GRF and no increase in basal GH level with pre-treatment of antiserum against somatostatin.
Positive_regulation (response) of GRF associated with somatostatin
14) Confidence 0.49 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.48
The effect of GH-releasing hormone (GHRH) on the release of the endogenous opioid dynorphin from rat adenohypophysis was investigated in vitro.
Spec (investigated) Positive_regulation (effect) of GHRH in adenohypophysis associated with dynorphin and endogenous opioid
15) Confidence 0.49 Published 1987 Journal Endocrinology Section Abstract Doc Link 2879724 Disease Relevance 0 Pain Relevance 0.22
The effect of GH-releasing hormone (GHRH) on the release of the endogenous opioid dynorphin from rat adenohypophysis was investigated in vitro.
Spec (investigated) Positive_regulation (effect) of GH-releasing hormone in adenohypophysis associated with dynorphin and endogenous opioid
16) Confidence 0.49 Published 1987 Journal Endocrinology Section Abstract Doc Link 2879724 Disease Relevance 0 Pain Relevance 0.22
Neither dermorphin nor 2549 released GH or augmented the GH responses of GHRP or GHRH in vitro by a direct pituitary action, while GHRH antiserum inhibited the GH response of both dermorphin and 2549 in vivo.
Positive_regulation (responses) of GHRH in pituitary
17) Confidence 0.48 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.53
GH and SRIF mRNA levels were significantly higher in alpha-FMH-treated pups than in controls, whereas no difference was observed in GHRH mRNA levels.
Positive_regulation (observed) of GHRH associated with somatostatin
18) Confidence 0.48 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.33
In contrast, GH response to a maximal dose of GH-releasing hormone (GHRH, 1 microgram/100 g BW), a peptide acting directly on pituitary somatotropes, is greater in AIA than in control rats.
Positive_regulation (response) of GHRH in somatotropes associated with arthritis
19) Confidence 0.48 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.84 Pain Relevance 0.61
In this study, we utilized the immunocytochemical detection of Fos protein to examine the effects of morphine- and GH-releasing hormone (GHRH)-induced GH release on the activation of arcuate nucleus neurons following GHS administration.
Spec (examine) Positive_regulation (-induced) of GH-releasing hormone in neurons associated with morphine
20) Confidence 0.48 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.32

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