INT51000

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.63
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
dorsal horn 1
Schwann cell 1
Atp9a (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 100.00 Very High Very High Very High
spinal dorsal horn 4 100.00 Very High Very High Very High
Bioavailability 1 98.50 Very High Very High Very High
Inflammation 76 97.88 Very High Very High Very High
Spinal cord 81 96.68 Very High Very High Very High
Hyperalgesia 34 94.16 High High
Central nervous system 55 92.08 High High
Angina 2 80.56 Quite High
Thermal hyperalgesia 28 78.68 Quite High
Stimulus evoked pain 4 77.56 Quite High
Disease Link Frequency Relevance Heat
Infection 106 99.12 Very High Very High Very High
Apoptosis 36 98.10 Very High Very High Very High
Togavirus Infection 150 97.88 Very High Very High Very High
INFLAMMATION 87 97.88 Very High Very High Very High
Hyperalgesia 62 94.16 High High
Disease 23 91.76 High High
Acute Coronary Syndrome 2 86.00 High High
Multiple Sclerosis 51 84.24 Quite High
Metabolic Syndrome 1 83.96 Quite High
Cv General 3 Under Development 1 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the nucleotide dependence of NMM IIA and actin recruitment was investigated in presence of GDP?
Positive_regulation (dependence) of IIA associated with addiction
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0.05
Although the actual mechanism facilitating peroxisome acto-myosin interaction is not known, binding of RhoA-GTP to the peroxisomal membrane may trigger this process possibly by activating NMM IIA.
Positive_regulation (activating) of IIA
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
Exercise tolerance increased in AP of functional class II-III and IV by 50 and 24%, respectively.
Positive_regulation (increased) of class II-III
3) Confidence 0.35 Published 1999 Journal Ter. Arkh. Section Body Doc Link 10515033 Disease Relevance 0.08 Pain Relevance 0
Then, as shown by quantitative analysis in Fig. 6, the expression of members in class I HDACs was found to be stable or be slightly reduced during the time period examined, while those in class IIa HDACs were upregulated significantly to different levels.
Positive_regulation (upregulated) of IIa
4) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.34 Pain Relevance 0.31
Using immunoblot analysis, we further found that the levels of class IIa HDAC members (HDAC4, 5, 7, 9) in the spinal dorsal horn were upregulated following CFA injection while those of class I HDAC members (HDAC1, 2, 3) remained stable or were slightly reduced.


Positive_regulation (upregulated) of IIa in dorsal horn associated with spinal dorsal horn
5) Confidence 0.09 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2942827 Disease Relevance 0.88 Pain Relevance 0.92
These changes were accompanied by a significant upregulation of MHC class I throughout the CVOs and induction of MHC class II on perivascular cells.
Positive_regulation (induction) of class II
6) Confidence 0.07 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.71 Pain Relevance 0.24
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of class II associated with inflammation, apoptosis and infection
7) Confidence 0.02 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.14 Pain Relevance 0.09
Several major histocompatibility complex (MHC) class II genes e.g., H2-D1, H2-D4 H2-Q7 and H2-T23 were upregulated at 72 hr and 96 hr post infection, concomitant with VEEV antigen appearance in the brain.
Positive_regulation (upregulated) of class II in brain associated with togavirus infection and infection
8) Confidence 0.02 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.98 Pain Relevance 0.20
, is required for endurance exercise-induced mitochondrial biogenesis and angiogenesis, whereas none of the p38 isoforms are required for IIb-to-IIa fiber-type transformation.
Positive_regulation (required) of IIb-to-IIa
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775956 Disease Relevance 0.08 Pain Relevance 0
In contrast to unfractionated heparin (UFH), LMWH have greater bioavailability, a more predictable anticoagulant response, longer half-life and a higher proportion of anti-factor Xa to anti-factor IIa activity.
Positive_regulation (proportion) of IIa associated with bioavailability
10) Confidence 0.02 Published 2005 Journal Expert Opin Pharmacother Section Abstract Doc Link 15957976 Disease Relevance 0.32 Pain Relevance 0.13
Using the Boyden chamber to observe Schwann cell migration, we found that cell migration increased after danshen and tanshinone IIA treatment (Figure 3(d)).
Positive_regulation (increased) of IIA in Schwann cell
11) Confidence 0.01 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.05 Pain Relevance 0
Zymography revealed MMP 9 enzyme activity increased after danshen and tanshinone IIA treatment (Figure 3(c)).
Positive_regulation (increased) of IIA
12) Confidence 0.01 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.06 Pain Relevance 0
In order to label all the commonly observed peaks with latency less than 5 milliseconds, it is necessary at times to use labels eIIa, eIIb, eIIIa, eIIIb, eIVa, eIVb, eVa, and eVb.
Positive_regulation (necessary) of eIIa
13) Confidence 0.00 Published 1995 Journal Ann Otol Rhinol Laryngol Suppl Section Abstract Doc Link 7668772 Disease Relevance 0 Pain Relevance 0

General Comments

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