INT51005

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Context Info
Confidence 0.08
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDYN, IL6) extracellular space (IL6) aging (IL6)
cell death (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
brain 1
PDYN (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 7 100.00 Very High Very High Very High
cytokine 2 96.12 Very High Very High Very High
Opioid 1 95.60 Very High Very High Very High
antagonist 1 86.40 High High
Endogenous opioid 2 86.32 High High
agonist 1 77.32 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 96.76 Very High Very High Very High
Cancer 1 96.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, dynorphin stimulated TNF-alpha and IL-6 in the brain cell cultures at both mRNA and protein levels, suggesting the involvement of these cytokines in opioid-induced HIV-1 expression.
dynorphin Positive_regulation (stimulated) of IL-6 in brain associated with dynorphin, acquired immune deficiency syndrome or hiv infection, opioid and cytokine
1) Confidence 0.08 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7669075 Disease Relevance 0.84 Pain Relevance 0.72

General Comments

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