INT51014

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Context Info
Confidence 0.71
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 42
Total Number 44
Disease Relevance 21.56
Pain Relevance 12.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T-cell 13
blood 7
plasma 2
brains 1
pia mater 1
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 369 100.00 Very High Very High Very High
Inflammation 310 100.00 Very High Very High Very High
chemokine 36 100.00 Very High Very High Very High
Morphine 27 99.80 Very High Very High Very High
Endogenous opioid 1 99.40 Very High Very High Very High
cINOD 10 99.34 Very High Very High Very High
Opioid 10 98.92 Very High Very High Very High
depression 6 97.92 Very High Very High Very High
Paracetamol 8 97.84 Very High Very High Very High
antagonist 37 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 321 100.00 Very High Very High Very High
Cancer 42 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Nociception 8 99.68 Very High Very High Very High
Complex Regional Pain Syndromes 27 99.48 Very High Very High Very High
Acrodermatitis 5 99.10 Very High Very High Very High
Disease 235 98.38 Very High Very High Very High
Erythema 9 98.22 Very High Very High Very High
Eczema 61 98.04 Very High Very High Very High
Depression 6 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human IL-2 mRNA was detected by in situ hybridization in the spinal pia mater and parenchyma of the lumbar, sacral, thoracic and cervical regions, and gray matter had higher level of IL-2 expression than white matter.
Transcription (detected) of IL-2 in parenchyma
1) Confidence 0.71 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.69 Pain Relevance 0.70
We know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14
Transcription (transduction) of IL2 in IL2R associated with cytokine
2) Confidence 0.61 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.44 Pain Relevance 0.05
We investigated the role of different crude decoction extracts of this plant on human T-lymphocyte proliferation and expression of IL-2 mRNA.
Transcription (expression) of IL-2 in T-lymphocyte
3) Confidence 0.52 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0.48 Pain Relevance 0.03
The induction of IL-2 gene transcription is a critical event for T-cell proliferation and effector functions.
Transcription (transcription) of IL-2 in T-cell
4) Confidence 0.52 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0 Pain Relevance 0
IL-10 and IL-2 messenger RNAs were undetectable in all brains examined.
Transcription (undetectable) of IL-2 in brains
5) Confidence 0.52 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.86 Pain Relevance 0.26
Further advancement was achieved by the discovery and the use of agents such as Tacrolimus which inhibits T-lymphocyte signal transduction and interleukin-2 transcription, and Sirolimus which inhibits the response to interleukin-2 thereby blocking the activation of T- and B-cells.


Transcription (transcription) of interleukin-2 in B-cells
6) Confidence 0.46 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703995 Disease Relevance 0.92 Pain Relevance 0.08
NSAIDs up-regulated TNF, IFN-gamma and IL-2 production at both the mRNA and protein levels, and IL-12 expression at the mRNA level.
Transcription (mRNA) of IL-2 associated with cinod
7) Confidence 0.42 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.29 Pain Relevance 0.63
We also assessed the expression of IL-2 mRNA and we noticed that different extracts of the Zizyphus exerted inhibitory effects (Figure 3).
Transcription (expression) of IL-2
8) Confidence 0.39 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0.49 Pain Relevance 0.03
We observed that different extracts inhibited T-cell blastogenesis and IL-2 mRNA expression.
Transcription (expression) of IL-2 in T-cell
9) Confidence 0.39 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0 Pain Relevance 0
Seed extracts exerted the most potent immunosuppressive effects on T cell proliferation and IL-2 mRNA expression.
Transcription (expression) of IL-2 in T cell
10) Confidence 0.39 Published 2010 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2955679 Disease Relevance 0 Pain Relevance 0
We demonstrated that morphine and the endogenous opioid beta-endorphin inhibited the transcription of IL-2 in activated human T lymphocytes as well as the activation of the transcription factors AP-1, NFAT, and NF-kappaB, which transactivate IL-2.
Transcription (transcription) of IL-2 in T lymphocytes associated with endogenous opioid and morphine
11) Confidence 0.38 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19561113 Disease Relevance 0.26 Pain Relevance 0.84
Moreover, we found that AM404 specifically inhibited both IL-2 and TNF-alpha gene transcription and TNF-alpha synthesis in CD3/CD28-stimulated Jurkat T cells in a FAAH independent way.
Transcription (transcription) of IL-2 in T cells
12) Confidence 0.33 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.21
CD3/28 mAb-induced interleukin-2 transcription was also inhibited by the opioids fentanyl and loperamide.
Transcription (transcription) of interleukin-2 associated with opioid
13) Confidence 0.32 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.93
Cyclosporine inhibits calcium-dependent signaling pathways in transcription of IL-2 gene by affecting intracellular binding proteins.
Transcription (transcription) of IL-2
14) Confidence 0.32 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.94 Pain Relevance 0.08
This complex of ciclosporin and cyclophilin inhibits calcineurin, which is responsible for activating the transcription of interleukin-2.
Transcription (transcription) of interleukin-2
15) Confidence 0.27 Published 2009 Journal Clin Transplant Section Abstract Doc Link 19930311 Disease Relevance 0.34 Pain Relevance 0.22
This leads to the uncoupling of CBP/p300 thereby abrogating IL-2 transcription.
Transcription (transcription) of IL-2
16) Confidence 0.26 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.55
Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels.
Transcription (transcriptional) of IL-2 associated with morphine
17) Confidence 0.25 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.35
Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels.
Transcription (transcriptional) of interleukin-2 associated with morphine
18) Confidence 0.25 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.35
Human IL-2 mRNA was detected by in situ hybridization in the spinal pia mater and parenchyma of the lumbar, sacral, thoracic and cervical regions, and gray matter had higher level of IL-2 expression than white matter.
Transcription (detected) of IL-2 in pia mater
19) Confidence 0.24 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.69 Pain Relevance 0.70
We have also studied cytokines associated with the function of Th2 (IL-4 and IL-10) and Th1 (IL-2, IL-12 (p70), and INF?)
Transcription (function) of IL-2 associated with cytokine
20) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.19 Pain Relevance 0.76

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