INT51017

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 113
Total Number 115
Disease Relevance 81.16
Pain Relevance 35.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
plasma 17
leukocyte 6
brain 3
monocyte 3
neutrophils 3
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 196 100.00 Very High Very High Very High
cytokine 155 100.00 Very High Very High Very High
Pain 72 100.00 Very High Very High Very High
IPN 43 99.98 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 162 99.96 Very High Very High Very High
Cluster headache 10 99.84 Very High Very High Very High
dexamethasone 44 99.80 Very High Very High Very High
calcitonin gene related peptide 3 99.56 Very High Very High Very High
cva 64 99.52 Very High Very High Very High
Inflammation 440 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 532 100.00 Very High Very High Very High
Cv General 3 Under Development 159 100.00 Very High Very High Very High
Apoptosis 93 100.00 Very High Very High Very High
Necrosis 65 100.00 Very High Very High Very High
Pain 52 100.00 Very High Very High Very High
Cancer 44 100.00 Very High Very High Very High
Sepsis 33 100.00 Very High Very High Very High
Inflammatory Pain 43 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 63 99.96 Very High Very High Very High
Death 42 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed that the induction of ICAM-1 was region specific with increased expression noted in the thalamus and frontal and parietal cortices, which directly correlated with increased expression of activated microglia.
Positive_regulation (induction) of ICAM-1 in microglia associated with thalamus
1) Confidence 0.70 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.81 Pain Relevance 1.03
The ability of the kappa-agonist, PD117302, to inhibit both the inflammation and upregulation of ICAM-1 in arthritic joints emphasizes the potential of kappa-agonists as antiarthritic agents.


Positive_regulation (upregulation) of ICAM-1 in joints
2) Confidence 0.69 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0 Pain Relevance 0
It appears that the kappa-opioid PD117302, but not the NSAID naproxen, inhibits the upregulation of ICAM-1 in arthritic joints, suggesting these agents act via different mechanisms.
Positive_regulation (upregulation) of ICAM-1 in joints
3) Confidence 0.69 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.05 Pain Relevance 0
Flurbiprofen caused a slight upregulation of ICAM-1 in the gastric mucosa and duodenum, whereas NO-flurbiprofen had no affect on expression.
Positive_regulation (upregulation) of ICAM-1 in duodenum
4) Confidence 0.68 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.35 Pain Relevance 0.07
Finally, the effect of the steroid on cytokine-induced ICAM-1 up-regulation was functionally related to its ability to suppress in vitro neutrophil trans-endothelial passage.
Positive_regulation (up-regulation) of ICAM-1 in neutrophil associated with cytokine
5) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.40 Pain Relevance 0.53
To establish the generality of dexamethasone inhibition upon ICAM-1 up-regulation, two other endothelial cell lines were assessed.
Positive_regulation (up-regulation) of ICAM-1 in endothelial cell associated with dexamethasone
6) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.39 Pain Relevance 0.41
Incubation of EA.hy926 cells with 1 microM dexamethasone prior to addition of TNF-alpha consistently reduced ICAM-1 induction by approximately 40%.
Positive_regulation (induction) of ICAM-1 associated with dexamethasone
7) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.44 Pain Relevance 0.37
Inhibition of ICAM-1 up-regulation may, at least in part, mediate the potent anti-migratory action displayed by this class of anti-inflammatory drugs.
Positive_regulation (up-regulation) of ICAM-1 associated with inflammation and cinod
8) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.42 Pain Relevance 0.53
RESULTS: Nerve root injury in the rat produced increased spinal major histocompatibility complex Class II, cluster determinant 4, ICAM-1, and PECAM-1 immunoreactivity and increased bilateral sensitivity to tactile stimuli.
Positive_regulation (increased) of ICAM-1 in Nerve
9) Confidence 0.60 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation.
Spec (whether) Positive_regulation (elevated) of intercellular adhesion molecule-1 in plasma associated with angina and adhesions
10) Confidence 0.56 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9415270 Disease Relevance 0.47 Pain Relevance 0.17
OBJECTIVE: The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation.
Spec (whether) Positive_regulation (elevated) of ICAM-1 in plasma associated with angina and adhesions
11) Confidence 0.56 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9415270 Disease Relevance 0.47 Pain Relevance 0.17
Patients with stable angina and hyperlipidemia compared with those with normal lipids had higher levels of sICAM-1.
Positive_regulation (levels) of sICAM-1 associated with angina and hyperlipidemia
12) Confidence 0.56 Published 2002 Journal Kardiologiia Section Abstract Doc Link 12494066 Disease Relevance 1.01 Pain Relevance 0.62
Levels of cytokines and sICAM-1 were elevated in patients with stable and were even higher in patients with unstable angina.
Positive_regulation (elevated) of sICAM-1 associated with angina and cytokine
13) Confidence 0.56 Published 2002 Journal Kardiologiia Section Abstract Doc Link 12494066 Disease Relevance 0.98 Pain Relevance 0.59
Immunological analysis on admission showed a high level of soluble ICAM-1 and ANCA negative, but that of soluble ICAM-1 was reduced after surgical operation and remained within normal range during an administration of prednisolone and cyclophosphamide.
Positive_regulation (level) of ICAM-1
14) Confidence 0.54 Published 1995 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 7671131 Disease Relevance 0.59 Pain Relevance 0.09
CONCLUSIONS: ICAM-1 and VCAM-1 levels are increased both in patients with CAD and with syndrome X compared with control individuals.
Positive_regulation (increased) of ICAM-1
15) Confidence 0.53 Published 2001 Journal Clin Cardiol Section Body Doc Link 11303698 Disease Relevance 0.18 Pain Relevance 0
Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines.
Positive_regulation (up-regulation) of intercellular adhesion molecule-1 in endothelial cell associated with dexamethasone, adhesions and cytokine
16) Confidence 0.53 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9274931 Disease Relevance 0.48 Pain Relevance 0.41
Soluble E-selectin and intercellular adhesion molecule-1 plasma levels increase during acute myocardial infarction.
Positive_regulation (increase) of intercellular adhesion molecule-1 in plasma associated with myocardial infarction and adhesions
17) Confidence 0.51 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 9335404 Disease Relevance 1.00 Pain Relevance 0.18
These results suggest that the increase in sICAM-1 is associated with repeated episodes of myocardial ischemia and reperfusion not leading to myocardial necrosis.
Positive_regulation (increase) of sICAM-1 associated with necrosis, coronary artery disease and ischemia
18) Confidence 0.50 Published 1997 Journal Jpn. Circ. J. Section Abstract Doc Link 9293403 Disease Relevance 1.71 Pain Relevance 0.89
The increase in sICAM-1 may play an important role as an inflammatory component in the pathogenesis of the ischemic myocardium.
Positive_regulation (increase) of sICAM-1 in myocardium associated with inflammation
19) Confidence 0.50 Published 1997 Journal Jpn. Circ. J. Section Abstract Doc Link 9293403 Disease Relevance 1.71 Pain Relevance 0.84
The findings of the present study were that CIP induces increased ICAM-1 mRNA and protein expression at the BBB and that systemic proinflammatory mediators play no apparent role in the early response (1-6 h); however, brain region-specific increases in microglial activation suggest a potential for a central-mediated response.
Positive_regulation (increased) of ICAM-1 mRNA in brain associated with ipn
20) Confidence 0.50 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.70 Pain Relevance 0.79

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