INT51028

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 28
Total Number 31
Disease Relevance 21.15
Pain Relevance 12.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophage 2
THP-1 2
liver 1
tail 1
skeletal muscle 1
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 121 100.00 Very High Very High Very High
cytokine 70 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Paracetamol 20 99.84 Very High Very High Very High
cINOD 13 99.84 Very High Very High Very High
narcan 7 99.84 Very High Very High Very High
Nerve growth factor 6 99.80 Very High Very High Very High
antagonist 8 99.44 Very High Very High Very High
withdrawal 5 98.96 Very High Very High Very High
Morphine 18 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 131 100.00 Very High Very High Very High
Appetite Loss 4 100.00 Very High Very High Very High
Nociception 4 100.00 Very High Very High Very High
Cv General 2 Under Development 2 100.00 Very High Very High Very High
Cancer 37 99.92 Very High Very High Very High
Granuloma 2 99.76 Very High Very High Very High
Pressure And Volume Under Development 18 99.68 Very High Very High Very High
Necrosis 15 99.68 Very High Very High Very High
Wallerian Degeneration 30 99.44 Very High Very High Very High
Hepatotoxicity 8 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MKGS also affected the levels of IL-1beta, TNF-alpha and NO induced by lambda-carrageenan.
Regulation (affected) of IL-1beta in MKGS
1) Confidence 0.60 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 1.04 Pain Relevance 0.57
No IL-1beta or TNF-alpha response was observed at any time point in either exposure model.
Neg (No) Regulation (response) of IL-1beta
2) Confidence 0.60 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 0.85 Pain Relevance 0.47
Compound influence on the formation ofTNF-alpha, IL-1beta, IL-6, and IL-8 was examined using LPS-stimulated monocytic cells (THP-1) and measurement of cytokine concentrations by specific ELISAs.
Regulation (influence) of IL-1beta in THP-1
3) Confidence 0.60 Published 1999 Journal Inflamm. Res. Section Body Doc Link 10450786 Disease Relevance 0.07 Pain Relevance 0
In stimulated monocytic cells (THP-1), lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected.
Regulation (affected) of IL-1beta in THP-1
4) Confidence 0.60 Published 1999 Journal Inflamm. Res. Section Body Doc Link 10450786 Disease Relevance 0 Pain Relevance 0
[Protective effect of interleukin-1 beta on acetaminophen induced liver damage in mice].
Regulation (effect) of interleukin-1 beta in liver associated with paracetamol and hepatotoxicity
5) Confidence 0.45 Published 1997 Journal Sheng Li Xue Bao Section Title Doc Link 9812850 Disease Relevance 0.25 Pain Relevance 0.75
Injection of thymulin only did not alter the nociceptive thresholds or the levels of IL-1beta and NGF.
Neg (not) Regulation (alter) of IL-1beta associated with nociception and nerve growth factor
6) Confidence 0.44 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.89 Pain Relevance 0.79
The results indicated that in the Dyn system neither the IL1beta in the spinal cord or brain implicated prostaglandin release because i.t. and i.c.v.
Neg (neither) Regulation (implicated) of IL1beta in brain associated with spinal cord
7) Confidence 0.44 Published 2002 Journal Life Sci. Section Abstract Doc Link 11860156 Disease Relevance 0 Pain Relevance 0.57
We presently document the involvement of the inflammatory cytokines TNFalpha, interleukin (IL)-1alpha, and IL-1beta in peripheral nerve (PNS) injury in C57/BL/6NHSD (C57/BL) mice that display the normal rapid progression of WD (rapid-WD) and C57/BL/6-WLD/OLA/NHSD mice that display abnormal slow progression of WD (slow-WD).
Regulation (involvement) of IL-1beta in PNS associated with inflammation, injury, wallerian degeneration and cytokine
8) Confidence 0.44 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.39 Pain Relevance 0.28
To investigate the effect of interleukin-1beta (IL-1beta) on I(A) and I(K) currents in cultured murine trigeminal ganglion (TG) neurons, whole-cell patch clamp technique was used to record the I(A) and I(K) currents before and after 20 ng/mL I(L)-1beta perfusion.
Spec (investigate) Regulation (effect) of IL-1beta in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
9) Confidence 0.44 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17497277 Disease Relevance 0.27 Pain Relevance 0.16
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of IL-1beta associated with necrosis, inflammation, cancer and cytokine
10) Confidence 0.44 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.04 Pain Relevance 0.44
Therefore, we examined direct effects of IL-1beta, intracerebroventricularly (i.c.v.), on morphine-induced analgesia, subcutaneously (s.c.), in diabetic and control mice by using the tail-flick test.
Spec (examined) Regulation (effects) of IL-1beta in tail associated with diabetes mellitus, tail-flick, analgesia and morphine
11) Confidence 0.44 Published 2000 Journal Pain Section Abstract Doc Link 11113291 Disease Relevance 0.70 Pain Relevance 1.29
RESULTS: Induction of an osteoarthritis-like condition in the TMJ in the Col1-IL-1betaXAT mouse model resulted in up-regulation of murine IL-1beta at the dorsal horns.
Regulation (regulation) of IL-1beta in dorsal horns
12) Confidence 0.44 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.13 Pain Relevance 0
Only mice lacking the EP3 receptor fail to show a febrile response to PGE2 and to either IL-1beta or LPS.
Regulation (response) of IL-1beta in PGE2 associated with cv general 2 under development
13) Confidence 0.44 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.81 Pain Relevance 0.20
MDT also affected the levels of interleukin-1beta, tumor necrosis factor-alpha, NO and MDA which were induced by lambda-carrageenan.
Regulation (affected) of interleukin-1beta associated with necrosis and cancer
14) Confidence 0.44 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.33 Pain Relevance 0.59
Cot/Tpl-2 kinase activation plays an integral role in the production of pro-inflammatory cytokines such as TNF and IL-1beta in this immune cell type.
Regulation (role) of IL-1beta in immune cell associated with inflammation and cytokine
15) Confidence 0.44 Published 2009 Journal Curr Top Med Chem Section Abstract Doc Link 19689369 Disease Relevance 0.65 Pain Relevance 0.35
No effects were observed on IL-1beta or MCP-1 expression.
Neg (No) Regulation (effects) of IL-1beta
16) Confidence 0.44 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.30 Pain Relevance 1.08
The effect of central administration of interleukin-1 beta on naloxone-precipitated withdrawal in morphine-dependent mice was studied.
Regulation (effect) of interleukin-1 beta associated with narcan, withdrawal and morphine
17) Confidence 0.42 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7671998 Disease Relevance 0.09 Pain Relevance 0.70
The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.
Spec (examined) Regulation (effects) of IL-1 beta associated with bordatella infection, inflammation and bacterial respiratory disease
18) Confidence 0.42 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.81 Pain Relevance 0.25
The beneficial or detrimental roles of these cytokines, including interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), remain to be clarified.
Regulation (roles) of IL-1beta associated with necrosis, cancer and cytokine
19) Confidence 0.31 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399681 Disease Relevance 0.50 Pain Relevance 0.18
The effects of mIL-1 beta on PEA mRNA expression in Con-A-activated thymocytes are different from its effects on Con-A-stimulated thymocyte proliferation.
Regulation (effects) of mIL-1 beta in thymocyte
20) Confidence 0.27 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.13

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