INT51029

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 29.34
Pain Relevance 23.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
leukocytes 2
frontal cortex 2
neutrophil 2
macrophages 1
spinal cord 1
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 169 100.00 Very High Very High Very High
cytokine 73 100.00 Very High Very High Very High
Abeta 20 100.00 Very High Very High Very High
Nerve growth factor 12 100.00 Very High Very High Very High
Hyperalgesia 17 99.92 Very High Very High Very High
antinociception 1 99.92 Very High Very High Very High
withdrawal 10 99.80 Very High Very High Very High
anesthesia 16 99.70 Very High Very High Very High
isoflurane 14 99.48 Very High Very High Very High
Paracetamol 7 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 160 100.00 Very High Very High Very High
Asthma 66 100.00 Very High Very High Very High
Nociception 10 100.00 Very High Very High Very High
Hyperalgesia 22 99.92 Very High Very High Very High
Leishmaniasis 14 99.92 Very High Very High Very High
Hypersensitivity 14 99.60 Very High Very High Very High
Appetite Loss 12 99.60 Very High Very High Very High
Alzheimer's Dementia 14 99.48 Very High Very High Very High
Nervous System Injury 13 99.48 Very High Very High Very High
Pain 38 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-alpha, IL-1beta, and IL-6 mRNA levels.
Negative_regulation (inhibited) of IL-1beta associated with ketamine
1) Confidence 0.57 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.15 Pain Relevance 0.68
Among the serum proinflammatory cytokines, the production of TNF-alpha in the BV group was suppressed compared to the control group (59 +/- 4.5 versus 99.5 +/- 6.5, p < 0.05), but IL-1beta was not suppressed.
Neg (not) Negative_regulation (suppressed) of IL-1beta associated with cytokine
2) Confidence 0.57 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15344419 Disease Relevance 0.99 Pain Relevance 0.68
Although interleukin-1beta and insoluble Abeta were more effectively reduced with longer treatment, the magnitude of the effect on soluble Abeta was not dependent on treatment duration.
Negative_regulation (reduced) of interleukin-1beta associated with abeta
3) Confidence 0.57 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755007 Disease Relevance 0.40 Pain Relevance 0.32
Moreover, central treatment of socially isolated mice with oxytocin, a neuropeptide associated with social bonding, attenuated the effects of SNI on depressive-like behavior and reduced frontal cortex IL-1beta protein levels in socially isolated animals.
Negative_regulation (reduced) of IL-1beta in frontal cortex
4) Confidence 0.57 Published 2010 Journal Psychosom Med Section Body Doc Link 20466999 Disease Relevance 0.06 Pain Relevance 0
IL-1beta, which was reduced in our animals by ibuprofen, induced mouse ACT in vitro.
Negative_regulation (reduced) of IL-1beta
5) Confidence 0.57 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.66 Pain Relevance 0.64
The obtained results showed a reduction in leukocytes and decrease in IL-1 beta level in PM mice.
Negative_regulation (reduction) of IL-1 beta in leukocytes associated with appetite loss
6) Confidence 0.56 Published 2006 Journal Egypt J Immunol Section Abstract Doc Link 18689271 Disease Relevance 0.78 Pain Relevance 0.36
Co-administration of alpha-melanocyte-stimulating hormone (300 ng/mouse) or alpha-helical corticotropin-releasing factor (CRF)-(9-41), a CRF receptor antagonist (300 ng/mouse), with interleukin-1 beta also antagonized the inhibitory effect of interleukin-1 beta (1 ng).
Negative_regulation (effect) of interleukin-1 beta in melanocyte associated with antagonist
7) Confidence 0.55 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7671998 Disease Relevance 0.06 Pain Relevance 0.80
Oral treatment with prednisolone and cyclosporin A of zymosan-challenged animals showed a dose-dependent reduction of IL-1 beta concentrations, but no effect of indomethacin.
Negative_regulation (reduction) of IL-1 beta
8) Confidence 0.54 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.73 Pain Relevance 0.23
In drug-treated BPV-challenged animals, prednisolone and cyclosporin A also showed a dose-dependent reduction of IL-1 beta, while indomethacin was again ineffective.
Negative_regulation (reduction) of IL-1 beta
9) Confidence 0.54 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.64 Pain Relevance 0.21
IL-1beta etiologically correlated with joint pathology, whereas TGFbeta expression associated with IL-1beta down-regulation and improvement of articular pathology.
Negative_regulation (down-regulation) of IL-1beta in articular
10) Confidence 0.42 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.14 Pain Relevance 0.73
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of IL-1beta in Spleen associated with withdrawal
11) Confidence 0.42 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).
Negative_regulation (reversed) of IL-1beta associated with leishmaniasis and nerve growth factor
12) Confidence 0.42 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.92 Pain Relevance 0.80
We conclude that thymulin can modulate the hyperalgesia induced by CL by decreasing the levels of the proinflammatory factors IL-1beta and NGF.
Negative_regulation (decreasing) of IL-1beta associated with leishmaniasis, hyperalgesia and nerve growth factor
13) Confidence 0.42 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 1.04 Pain Relevance 0.77
PPADS (25mg/kg) completely reversed nociceptive hypersensitivity and simultaneously reduced the increased NO/NOS system and IL-1beta in both peripheral (injured sciatic nerve and L4-L6 ipsilateral dorsal root ganglia) and central steps of nervous system (L4-L6 spinal cord and thalamus) involved in pain signalling.
Negative_regulation (reduced) of IL-1beta in thalamus associated with nociception, pain, hypersensitivity, thalamus, sciatic nerve and spinal cord
14) Confidence 0.42 Published 2008 Journal Pain Section Abstract Doc Link 17900807 Disease Relevance 1.47 Pain Relevance 1.49
The obtained results showed a reduction in leukocytes and decrease in IL-1 beta level in PM mice.
Negative_regulation (decrease) of IL-1 beta in leukocytes associated with appetite loss
15) Confidence 0.42 Published 2006 Journal Egypt J Immunol Section Abstract Doc Link 18689271 Disease Relevance 0.78 Pain Relevance 0.35
In separate experiments, we administered AdTNF-alpha or AdIL-1beta to mice deficient in ICAM-1.
Negative_regulation (administered) of IL-1beta
16) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.63 Pain Relevance 0.23
Ozone also reduced IL-1beta staining in the orbito-frontal cortex in neuropathic mice.
Negative_regulation (reduced) of IL-1beta in frontal cortex associated with neuropathic pain and urological neuroanatomy
17) Confidence 0.41 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.98 Pain Relevance 0.82
C. baccatum juice also reduced neutrophil recruitment and exudate levels of pro-inflammatory cytokines TNF-alpha and IL-1beta in mouse inflammatory immune peritonitis.
Negative_regulation (reduced) of IL-1beta in neutrophil associated with inflammation, peritonitis and cytokine
18) Confidence 0.41 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18380920 Disease Relevance 1.59 Pain Relevance 0.90
In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.
Negative_regulation (downregulation) of IL-1beta
19) Confidence 0.41 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.81 Pain Relevance 0.20
In the pro-inflammatory cytokine pain model, a single immobilization stress decreased the pain behaviors induced by TNF-alpha, IL-1beta administered i.t. but not by IFN-gamma administered i.t.
Neg (not) Negative_regulation (administered) of IL-1beta associated with stress, pain, inflammation and cytokine
20) Confidence 0.41 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113957 Disease Relevance 1.67 Pain Relevance 1.48

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