INT5103

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Context Info
Confidence 0.33
First Reported 1988
Last Reported 1992
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal, Gh1) mitochondrion (Gh1) Golgi apparatus (Gal)
response to stress (Gal) cytoplasm (Gal) cytosol (Gh1)
Anatomy Link Frequency
neurons 2
median eminence 2
Gal (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 9 98.20 Very High Very High Very High
Clonidine 7 93.32 High High
narcan 3 31.92 Quite Low
Opioid 1 31.12 Quite Low
dopamine receptor 1 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Immunization 1 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all these data indicate that in the infant rat 1) GAL is a potent GH secretagogue; 2) the action of GAL is not exerted directly on GHRF- or somatostatin-secreting structures, but requires the intervention of catecholaminergic neurons; 3) the GH-releasing effect of GAL is ultimately exerted via GHRF release, although a mechanism operating to inhibit hypothalamic somatostatin release cannot be ruled out; and 4) differently from GAL, CLO releases GH via postsynaptic stimulation of GHRF-secreting neurons.
GAL Regulation (effect) of Localization (releasing) of GH in neurons associated with somatostatin and clonidine
1) Confidence 0.33 Published 1988 Journal Endocrinology Section Abstract Doc Link 2449342 Disease Relevance 0.08 Pain Relevance 0.61
Thus, to investigate whether the effect of galanin on GH release is the result of either a stimulation of GH-releasing factor (GRF) and/or an inhibition of somatostatin (SRIF) release, we have evaluated the action of galanin on the release of SRIF and GRF from median eminence (ME) fragments in vitro.
galanin Spec (whether) Regulation (effect) of Spec (investigate) Localization (release) of GH in median eminence associated with somatostatin
2) Confidence 0.06 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1285434 Disease Relevance 0 Pain Relevance 0.21

General Comments

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