INT51030

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 5.83
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LMOD1) cytoskeleton (LMOD1) cytoplasm (LMOD1)
Anatomy Link Frequency
muscle 2
striatum 1
MCF-7 1
frontal cortex 1
LMOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 555 100.00 Very High Very High Very High
depression 9 100.00 Very High Very High Very High
Inflammation 69 99.36 Very High Very High Very High
Serotonin 4 99.24 Very High Very High Very High
antagonist 179 98.44 Very High Very High Very High
cytokine 38 98.32 Very High Very High Very High
agonist 174 97.06 Very High Very High Very High
Neurotransmitter 33 95.72 Very High Very High Very High
opioid receptor 2 95.08 Very High Very High Very High
amygdala 3 93.52 High High
Disease Link Frequency Relevance Heat
Depression 9 100.00 Very High Very High Very High
Skin Cancer 7 99.56 Very High Very High Very High
INFLAMMATION 77 99.36 Very High Very High Very High
Urological Neuroanatomy 2 99.00 Very High Very High Very High
Muscle Rigidity 20 98.28 Very High Very High Very High
Schizophrenia 6 98.28 Very High Very High Very High
Disease 76 97.84 Very High Very High Very High
Breast Cancer 69 97.68 Very High Very High Very High
Apoptosis 72 97.00 Very High Very High Very High
Adenocarcinoma 4 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of sigma ligands in MCF-7 and melanoma cells was not due to blockade of dopamine D1 and D2 receptors, serotonin (5-HT2) receptors, N-methyl-D-aspartate (NMDA)/phencyclidine receptors, beta-adrenoceptors or opioid receptors, since 100 microM SCH 23390, raclopride, mianserin, (+)-MK-801, propranolol and 1 microM naloxone respectively, were ineffective.
Negative_regulation (blockade) of D1 in MCF-7 associated with dopamine, narcan, opioid receptor, skin cancer and serotonin
1) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7671999 Disease Relevance 1.14 Pain Relevance 0.79
According to our model, the pathologic tone disinhibition may be a consequence of impaired dopamine/D1 interaction.
Negative_regulation (impaired) of D1 associated with dopamine
2) Confidence 0.40 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.81 Pain Relevance 0.36
We suggest that the greater reduction of dopamine/D1 interaction may be caused by further impairment of presynaptic dopamine release by one or more of several neurotransmitters that are activated by proprioreceptive mechanisms with influences on presynaptic nigrostriatal dopaminergic terminals.
Negative_regulation (reduction) of D1 associated with neurotransmitter and dopamine
3) Confidence 0.40 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.21 Pain Relevance 0.50
In the proposed hypothesis, impaired D1 activation lead to tone disinhibition and muscular rigidity, whereas impaired D2 effects induce diminished acceleration of muscle contraction and bradykinesia.
Negative_regulation (impaired) of D1 in muscle associated with hypokinesia and muscle rigidity
4) Confidence 0.39 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.92 Pain Relevance 0.31
RESULTS: After a high-level CES, the positive FA and AM of the current efflux showed a significant increase at the early phase 34 ms, and significantly decreased at 45 ms in D1 SEPs.
Negative_regulation (decreased) of D1
5) Confidence 0.38 Published 2006 Journal Clin Neurophysiol Section Body Doc Link 16545600 Disease Relevance 0 Pain Relevance 0
The maximal D1 mediated tone reduction occurs as all D1 receptors are saturated.
Negative_regulation (reduction) of D1
6) Confidence 0.35 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.50
Inhibited dopamine release causes diminished D1 stimulation, and as a consequence, muscle tone acutely increases.
Negative_regulation (diminished) of D1 in muscle associated with dopamine
7) Confidence 0.34 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.14 Pain Relevance 0.24
In this regard, a decrease in D1 receptor density in the frontal cortex of schizophrenic patients with negative signs have been shown no change in the striatum [43-45].


Negative_regulation (decrease) of D1 in frontal cortex associated with urological neuroanatomy and schizophrenia
8) Confidence 0.20 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2958859 Disease Relevance 1.37 Pain Relevance 0.47
inhibition of E2F/DP DNA binding [129], the inhibition of cyclins D1 and E,
Negative_regulation (inhibition) of D1
9) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.36 Pain Relevance 0.14
Agonists that potentiate dopaminergic neurotransmission improve the speed of motor responses in animals, whereas striatal dopamine depletion and selective blockade of dopamine D1 or D2 receptors significantly impair performance on reaction time tasks (13,16,17).
Negative_regulation (blockade) of D1 associated with dopamine and agonist
10) Confidence 0.09 Published 2008 Journal Biological Psychiatry Section Body Doc Link PMC2885493 Disease Relevance 0.05 Pain Relevance 0.63
Extra-cellular dopamine levels are increased in the striatum, causing a depression in mRNA levels of both D1 and D2 receptors and decreased stores of dopamine [71, 96].
Negative_regulation (depression) of D1 in striatum associated with dopamine and depression
11) Confidence 0.05 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.20 Pain Relevance 0.57
7.6 ű0.6) and closed (d1<6.25 Å) 30% of the time (d1?
Negative_regulation (closed) of d1
12) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
This was associated with downregulation of the levels of cyclins D1 and B1, and with inhibition of CDK1, CDK2 and CDK4.
Negative_regulation (downregulation) of cyclins D1
13) Confidence 0.01 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.62 Pain Relevance 0.07

General Comments

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