INT51047

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.00
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 15 100.00 Very High Very High Very High
agonist 10 99.96 Very High Very High Very High
Morphine 7 99.20 Very High Very High Very High
cocaine 7 97.12 Very High Very High Very High
opiate 4 94.72 High High
addiction 2 94.44 High High
Eae 4 92.76 High High
lidocaine 1 90.16 High High
qutenza 1 77.64 Quite High
Nicotine 2 75.48 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 16 100.00 Very High Very High Very High
Opiate Addiction 2 94.80 High High
Erectile Dysfunction 8 94.32 High High
Hypothermia 4 93.44 High High
Injury 1 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current studies were aimed at better defining the effects of food restriction on D2 and D3 receptor function by assessing the capacity of N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole) to induce yawning, penile erection (PE), hypothermia, and locomotor activity in free-fed and food-restricted rats.
Regulation (effects) of D3 receptor associated with hypothermia, erectile dysfunction, eae and eating disorder
1) Confidence 0.53 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305018 Disease Relevance 0.97 Pain Relevance 0.56
Behavioral and molecular studies suggest that augmented dopaminergic responses observed in food-restricted animals result from a sensitization of the dopamine D2 receptor; however, little is known about how food restriction affects dopamine D3 receptor function.
Regulation (affects) of D3 receptor associated with dopamine and eating disorder
2) Confidence 0.46 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305018 Disease Relevance 0.85 Pain Relevance 0.54
Our results demonstrated that sensory afferent neurones, alpha 2-adrenoceptors and D2-dopaminergic receptors all play a significant role in the defensive mechanism of the gastric mucosa and the adaptive cytoprotection of 20% ethanol, while the M1- and M2-muscarinic receptors and sensory chemoreceptors on the gastric mucosa contribute only to the former action.
Regulation (role) of D2-dopaminergic
3) Confidence 0.45 Published 1995 Journal J Auton Pharmacol Section Abstract Doc Link 7673275 Disease Relevance 0.09 Pain Relevance 0.20
OBJECTIVES: This study analysed the effects of a selective partial D3 receptor agonist, BP 897, on morphine-conditioned place preference (CPP) in deprived and handled rats.
Spec (analysed) Regulation (effects) of D3 receptor
4) Confidence 0.40 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17492273 Disease Relevance 0.09 Pain Relevance 0
Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats.
Regulation (Effects) of dopamine D3 receptor associated with dopamine, cocaine and morphine
5) Confidence 0.36 Published 2003 Journal Neuropsychopharmacology Section Title Doc Link 12915863 Disease Relevance 0 Pain Relevance 0.51
Maternal deprivation and handling modify the effect of the dopamine D3 receptor agonist, BP 897 on morphine-conditioned place preference in rats.
Regulation (effect) of D3 receptor associated with dopamine, agonist and morphine
6) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl.) Section Title Doc Link 17492273 Disease Relevance 0 Pain Relevance 0.39

General Comments

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