INT51051

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.79
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, IL6) aging (IL1B, IL6) extracellular region (IL1B, IL6)
cytosol (IL1B) signal transduction (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
astrocytes 10
IL1B (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 20 99.84 Very High Very High Very High
COX2 5 99.62 Very High Very High Very High
cINOD 16 94.08 High High
Inflammation 15 89.24 High High
cytokine 5 88.20 High High
diclofenac 1 5.00 Very Low Very Low Very Low
interstitial cystitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 25 99.16 Very High Very High Very High
INFLAMMATION 32 93.88 High High
Disease 20 91.48 High High
Necrosis 2 60.16 Quite High
Cancer 2 59.80 Quite High
Overactive Bladder 2 50.00 Quite Low
Interstitial Cystitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.
IL-1 Positive_regulation (induced) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma
1) Confidence 0.57 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.60 Pain Relevance 0.30
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
IL-1beta Positive_regulation (induced) of Localization (release) of IL-6
2) Confidence 0.44 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.12 Pain Relevance 0
Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.
IL-1beta-activated Positive_regulation (activated) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma and dexamethasone
3) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.51 Pain Relevance 0.21
NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2.
IL-1 Positive_regulation (induced) of Localization (release) of IL-6 in astrocytes associated with cox2
4) Confidence 0.41 Published 1997 Journal Brain Res. Section Title Doc Link 9449430 Disease Relevance 0.90 Pain Relevance 0.54
The glucocorticoid dexamethasone inhibited the IL-1beta-activated release of IL-6 from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines.
IL-1beta-activated Positive_regulation (activated) of Localization (release) of IL-6 in astrocyte associated with anaplastic astrocytoma and dexamethasone
5) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.95 Pain Relevance 0.49
Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.
IL-1beta-activated Positive_regulation (activated) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma
6) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.71 Pain Relevance 0.33
IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.
IL-1 Positive_regulation (induced) of Localization (release) of IL-6
7) Confidence 0.33 Published 1995 Journal J. Rheumatol. Section Body Doc Link 7674242 Disease Relevance 0 Pain Relevance 0

General Comments

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