INT51053

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.67
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
brain 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 10 99.36 Very High Very High Very High
Inflammation 344 98.04 Very High Very High Very High
fibrosis 75 79.92 Quite High
metalloproteinase 9 68.20 Quite High
cytokine 71 31.92 Quite Low
sodium channel 15 20.00 Low Low
Inflammatory response 27 10.48 Low Low
agonist 9 7.36 Low Low
cINOD 19 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gingival Overgrowth 30 98.40 Very High Very High Very High
INFLAMMATION 388 98.04 Very High Very High Very High
Obesity 218 84.92 Quite High
Fibrosis 12 79.92 Quite High
Pulmonary Fibrosis 65 78.00 Quite High
Pulmonary Disease 3 73.56 Quite High
Insulin Resistance 20 69.92 Quite High
Hyperinsulinism 8 53.40 Quite High
Myocardial Infarction 11 52.76 Quite High
Chronic Disease 16 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we observed a concomitant increase in TIMP-1, the main inhibitor of MMP-1 (as well as MMP-2 and ?
Negative_regulation (inhibitor) of Positive_regulation (increase) of TIMP
1) Confidence 0.35 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.42 Pain Relevance 0.17
When MMP levels decrease and/or TIMP levels increase, the turnover of ECM diminishes, potentially leading to an exuberant accumulation of these proteins.
Negative_regulation (diminishes) of Positive_regulation (increase) of TIMP
2) Confidence 0.21 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.03
g/mL of either PHT or HPPH prior to LPS stimulation prevented a significant increase in MMP-9 and TIMP-1 (Fig. 1D and Fig. 2).
Negative_regulation (prevented) of Positive_regulation (increase) of TIMP-1
3) Confidence 0.21 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
This reflects more a decrease in MMP production rather than an increase in TIMP.
Negative_regulation (decrease) of Positive_regulation (increase) of TIMP
4) Confidence 0.19 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.15 Pain Relevance 0.03
However, increasing the levels of EPA in the brain can inhibit the binding of endocannabinoids [115].
Negative_regulation (inhibit) of Positive_regulation (increasing) of EPA in brain associated with endocannabinoid
5) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.48 Pain Relevance 0.23
More importantly, an increased EPA content in the membrane phospholipids decreases the release of AA that is necessary to make pro-inflammatory eicosanoids.
Negative_regulation (decreases) of Positive_regulation (increased) of EPA associated with inflammation
6) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.54 Pain Relevance 0.22
IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.
Negative_regulation (inhibited) of Positive_regulation (induced) of collagenase
7) Confidence 0.05 Published 1995 Journal J. Rheumatol. Section Body Doc Link 7674242 Disease Relevance 0 Pain Relevance 0

General Comments

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