INT51054

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 45
Total Number 47
Disease Relevance 24.48
Pain Relevance 18.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
astrocytes 12
NK cells 6
fibroblast 4
macrophages 2
PSC 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 450 100.00 Very High Very High Very High
dexamethasone 125 100.00 Very High Very High Very High
Adalimumab 102 99.98 Very High Very High Very High
Paracetamol 18 99.98 Very High Very High Very High
COX2 56 99.86 Very High Very High Very High
substance P 15 99.68 Very High Very High Very High
Inflammation 413 99.50 Very High Very High Very High
fortral 3 99.48 Very High Very High Very High
rheumatoid arthritis 36 99.44 Very High Very High Very High
qutenza 16 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 570 100.00 Very High Very High Very High
Necrosis 29 100.00 Very High Very High Very High
Urinary Tract Infection 27 99.98 Very High Very High Very High
INFLAMMATION 527 99.50 Very High Very High Very High
Rheumatoid Arthritis 36 99.44 Very High Very High Very High
Anaplastic Astrocytoma 30 99.38 Very High Very High Very High
Osteoarthritis 12 99.32 Very High Very High Very High
Disease 201 99.20 Very High Very High Very High
Post-traumatic Stress Disorder 88 99.16 Very High Very High Very High
Pain 18 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical field stimulation intensively reduced IL-6 secretion.
Negative_regulation (reduced) of Localization (secretion) of IL-6
1) Confidence 0.59 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.93 Pain Relevance 0.70
In patients with OA or RA, this electrically induced reduction of IL-6 secretion was not significantly changed by alpha- or beta-adrenergic antagonists.
Negative_regulation (reduction) of Localization (secretion) of IL-6 associated with antagonist, rheumatoid arthritis and osteoarthritis
2) Confidence 0.59 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.91 Pain Relevance 0.70
The non-specific cyclooxygenase inhibitor indomethacin and BF389 only suppressed the IL-6 release by post-mortem astrocyte culture A157.
Negative_regulation (suppressed) of Localization (release) of IL-6 in astrocyte
3) Confidence 0.57 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 1.00 Pain Relevance 0.47
RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation.
Negative_regulation (reduction) of Localization (release) of IL-6
4) Confidence 0.56 Published 2009 Journal Aktuelle Urol Section Body Doc Link 19296424 Disease Relevance 0 Pain Relevance 0
Blockade of the production of met-enkephalin and enkephalin-containing intermediary peptides resulted in enhancement of the proliferative T cell response and inhibition of monocyte IL-6 secretion.
Negative_regulation (inhibition) of Localization (secretion) of IL-6 in monocyte associated with enkephalin
5) Confidence 0.49 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9600708 Disease Relevance 0 Pain Relevance 1.13
In macrophages, acetaminophen decreased the secretion of TNF-alpha (at 4 and 24 h, concentration-related) and IL-6 (at 24 h, at 0.1 mM), and did not affect significantly IL-8 production.
Negative_regulation (decreased) of Localization (secretion) of IL-6 in macrophages associated with paracetamol
6) Confidence 0.44 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15878691 Disease Relevance 0.24 Pain Relevance 0.76
Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.
Negative_regulation (effect) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma and dexamethasone
7) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.51 Pain Relevance 0.21
Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.
Negative_regulation (prevented) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma and dexamethasone
8) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.50 Pain Relevance 0.21
LPS-induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS-induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected.
Negative_regulation (inhibited) of Localization (release) of IL-6
9) Confidence 0.42 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515409 Disease Relevance 0.50 Pain Relevance 0.19
The glucocorticoid dexamethasone inhibited the IL-1beta-activated release of IL-6 from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines.
Negative_regulation (inhibited) of Localization (release) of IL-6 in astrocyte associated with anaplastic astrocytoma and dexamethasone
10) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.96 Pain Relevance 0.49
Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.
Negative_regulation (prevented) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma
11) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.84 Pain Relevance 0.39
NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2.
Negative_regulation (inhibit) of Localization (release) of IL-6 in astrocytes associated with cox2
12) Confidence 0.42 Published 1997 Journal Brain Res. Section Title Doc Link 9449430 Disease Relevance 0.90 Pain Relevance 0.54
A decoy oligodeoxynucleotide bearing the NF-kappaB binding site inhibited ET-1-stimulated IL-6 release to a great extent suggesting that this transcription factor plays a key role for cytokine production elicited by ET-1 [129].


Negative_regulation (inhibited) of Localization (release) of IL-6 associated with cytokine
13) Confidence 0.37 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.88 Pain Relevance 0.16
NF-kappaB nuclear translocation and IL-6 secretion induced by UVB and UVA were dramatically inhibited by treatment of EGCG [176].
Negative_regulation (inhibited) of Localization (secretion) of IL-6
14) Confidence 0.37 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.87 Pain Relevance 0.09
However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels.
Negative_regulation (inhibited) of Localization (release) of IL-6 associated with qutenza, antagonist and cytokine
15) Confidence 0.35 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9882597 Disease Relevance 0.36 Pain Relevance 0.99
However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels.
Negative_regulation (reduced) of Localization (release) of IL-6 associated with qutenza, antagonist and cytokine
16) Confidence 0.35 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9882597 Disease Relevance 0.35 Pain Relevance 0.97
FGF-2 rapidly induced activation of ERK1/2 and p38 MAP kinases, and specific inhibitors for these enzymes significantly reduced FGF-2-induced IL-6 release.
Negative_regulation (reduced) of Localization (release) of IL-6
17) Confidence 0.35 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.
Negative_regulation (inhibited) of Localization (release) of IL-6
18) Confidence 0.33 Published 1995 Journal J. Rheumatol. Section Body Doc Link 7674242 Disease Relevance 0 Pain Relevance 0
These in vitro observations demonstrate that clinically relevant concentrations of acetaminophen decreased: (i) intracellular GSH in human pulmonary macrophages and type II pneumocytes and (ii) the secretion of TNF-alpha and possibly IL-6 by human pulmonary macrophages.
Spec (possibly) Negative_regulation (decreased) of Localization (secretion) of IL-6 in pneumocytes associated with paracetamol
19) Confidence 0.32 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15878691 Disease Relevance 0.16 Pain Relevance 0.60
Activation of cannabinoid receptors, however, induced de-activation of PSC and dose-dependently inhibited growth and decreased IL-6 and MCP-1 secretion as well as fibronectin, collagen1 and alphaSMA levels.
Negative_regulation (decreased) of Localization (secretion) of IL-6 in PSC associated with cannabinoid receptor and primary sclerosing cholangitis
20) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2253501 Disease Relevance 1.20 Pain Relevance 1.02

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