INT51055

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 103
Total Number 105
Disease Relevance 50.07
Pain Relevance 19.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
chondrocytes 6
epithelium 3
leukocytes 3
macrophages 2
optic nerve head 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 974 100.00 Very High Very High Very High
Osteoarthritis 634 99.84 Very High Very High Very High
Inflammation 1279 99.52 Very High Very High Very High
Inflammatory mediators 40 99.40 Very High Very High Very High
Inflammatory response 86 99.38 Very High Very High Very High
fibrosis 390 99.10 Very High Very High Very High
cytokine 617 99.00 Very High Very High Very High
Arthritis 252 98.40 Very High Very High Very High
Endocannabinoid 10 98.36 Very High Very High Very High
Dismenorea 7 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Wrinkles 11 100.00 Very High Very High Very High
Nicotine Addiction 182 99.98 Very High Very High Very High
Major Depressive Disorder 50 99.96 Very High Very High Very High
Tendon Injuries 48 99.92 Very High Very High Very High
Breast Cancer 128 99.84 Very High Very High Very High
Frailty 106 99.84 Very High Very High Very High
Urological Neuroanatomy 17 99.80 Very High Very High Very High
Ocular Hypertension 242 99.72 Very High Very High Very High
Metabolic Syndrome 71 99.72 Very High Very High Very High
Infection 35 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Positive_regulation (elevation) of collagenase in PGE2
1) Confidence 0.69 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.16 Pain Relevance 0.24
Another randomized study using 1.8 g/day EPA–DHA in a similar population of 200 patients saw an increase of EPA and DHA from 4.7% to 8.3% in the patients' red blood cells (Raitt et al 2005).
Positive_regulation (increase) of EPA in red blood cells
2) Confidence 0.57 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.29 Pain Relevance 0
This intervention increased the levels of EPA and DHA in the red blood cells in the actively treated group from 3.5±0.1% to 7.6±0.3%.
Positive_regulation (increased) of EPA in red blood cells
3) Confidence 0.57 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.53 Pain Relevance 0
In comparison to the expression data in tissue described above, these results confirm that circulating MMPs and TIMPs do not always reflect the direct tissue situation.
Positive_regulation (circulating) of TIMP associated with metalloproteinase
4) Confidence 0.49 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.46 Pain Relevance 0.19
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Positive_regulation (matrix) of TIMP associated with metalloproteinase
5) Confidence 0.49 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.55 Pain Relevance 0.16
While there are many transcripts in Table 3 common to the different conditions, there are a few that are unique to a specific disease/condition, such as those encoding kinase deficient protein (WNK1), timp metallopeptidase inhibitor 1 (TIMP1) and cystathionine-beta-synthase (CBS), which are specific to CVD.
Positive_regulation (timp) of TIMP1 associated with cardiovascular disease and disease
6) Confidence 0.48 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 1.31 Pain Relevance 0.05
Both sensitivity and specificity increased to over 90% with the three-marker combination MMP2, MMP9, and TIMP1 (Table 4, Figure 2).
Positive_regulation (increased) of TIMP1
7) Confidence 0.44 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.14 Pain Relevance 0.04
However, an increase in MMP-9 activity and a decrease in TIMP-1 protein levels were observed following the establishment of uterine contractions in media conditioned by amnion.
Positive_regulation (increase) of TIMP-1 in amnion associated with dismenorea
8) Confidence 0.44 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.35 Pain Relevance 0.40
Shown in Fig. 5, our integrated analyses suggest that the differential abundance of urine peptides in SJIA urine may be an outcome of both the pathophysiological changes initiated by IL-18 and RANTES and P/L-Selectin-mediated inflammatory responses and the function of leukocyte-derived TIMP1/MMP9; the latter would influence protein catabolism in SJIA.
Positive_regulation (derived) of TIMP1 in urine associated with inflammatory response
9) Confidence 0.44 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.79 Pain Relevance 0.38
While there are many transcripts in Table 3 common to the different conditions, there are a few that are unique to a specific disease/condition, such as those encoding kinase deficient protein (WNK1), timp metallopeptidase inhibitor 1 (TIMP1) and cystathionine-beta-synthase (CBS), which are specific to CVD.
Positive_regulation (timp) of metallopeptidase inhibitor 1 associated with cardiovascular disease and disease
10) Confidence 0.42 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 1.31 Pain Relevance 0.05
Interestingly, however, a profound positive effect of 3.4 g/day EPA–DHA on the patency of newly constructed hemodialysis polytetrafluorethylene grafts was observed in a randomized one-year study in 24 patients (Schmitz et al 2002).
Positive_regulation (effect) of EPA
11) Confidence 0.41 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.27 Pain Relevance 0
The average time- and frequencydomain parameters of heart rate variability increased significantly during the six month intervention period after EPA–DHA and after soy bean oil, with EPA–DHA being more effective (Holguin et al 2005).
Positive_regulation (increased) of EPA in heart
12) Confidence 0.41 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.47 Pain Relevance 0
Additionally, we observed a concomitant increase in TIMP-1, the main inhibitor of MMP-1 (as well as MMP-2 and ?
Positive_regulation (increase) of TIMP
13) Confidence 0.41 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.42 Pain Relevance 0.17
Osteopontin increases TIMP-1 expression by fibroblasts
Positive_regulation (increases) of TIMP in fibroblasts
14) Confidence 0.41 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
Northern blot analysis (Figure 7A) revealed an increase in TIMP-1 gene expression at 0.4 ?
Positive_regulation (increase) of TIMP
15) Confidence 0.41 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
Fluoroquinolones may also activate metalloproteinases in tendon cells and hence collagenolytic injuries [125].
Positive_regulation (activate) of metalloproteinases in tendon cells associated with injury and metalloproteinase
16) Confidence 0.40 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 0.96 Pain Relevance 0.44
In cells chronically treated with EPA, the EPA content of the cell lipid fraction (mol%) increased time-dependently, while arachidonic acid (AA) decreased, resulting in an increase of EPA to AA ratio.
Positive_regulation (increase) of EPA
17) Confidence 0.40 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.11
We then examined whether the decreased contribution of MMPs in those fluids with a high proteolytic activity correlated with an increased TIMP-1 secretion.
Spec (whether) Positive_regulation (increased) of TIMP
18) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.26 Pain Relevance 0.51
Finally, and most interestingly, increased TIMP-1 secretion by leukocytes in patients with IA shifted the balance toward an MMP-independent proteolytic activity in those SF with high NPA.
Positive_regulation (increased) of TIMP in leukocytes associated with metalloproteinase and arthritis
19) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.69 Pain Relevance 0.43
The average time- and frequencydomain parameters of heart rate variability increased significantly during the six month intervention period after EPA–DHA and after soy bean oil, with EPA–DHA being more effective (Holguin et al 2005).
Positive_regulation (increased) of EPA in heart
20) Confidence 0.38 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.48 Pain Relevance 0

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