INT51064

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.02
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
neurons 4
blood 2
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 99.84 Very High Very High Very High
Central nervous system 3 96.04 Very High Very High Very High
Neuritis 1 92.12 High High
antidepressant 90 90.92 High High
analgesia 1 88.60 High High
cINOD 3 86.48 High High
Multiple sclerosis 1 86.36 High High
Inflammation 10 86.00 High High
depression 28 85.52 High High
cytokine 2 85.08 High High
Disease Link Frequency Relevance Heat
Depression 112 100.00 Very High Very High Very High
Stress 8 100.00 Very High Very High Very High
Sepsis 6 99.60 Very High Very High Very High
Neuromyelitis Optica 14 98.52 Very High Very High Very High
Rheumatoid Arthritis 1 95.44 Very High Very High Very High
Demyelinating Disease 2 94.88 High High
Obesity 27 94.40 High High
Transverse Myelitis 1 93.60 High High
Optic Neuritis 1 92.36 High High
Encephalopathy 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hippocampal serotonin levels influence the expression of S100 beta detected by immunocytochemistry.
Regulation (influence) of Gene_expression (expression) of S100 beta associated with serotonin
1) Confidence 0.60 Published 1993 Journal Brain Res. Section Title Doc Link 8298984 Disease Relevance 0 Pain Relevance 0.17
Effect of proportion of Eudragit L100 and Eudragit S100 in matrix either alone or in combination was evaluated.
Regulation (Effect) of Gene_expression (proportion) of S100
2) Confidence 0.44 Published 2008 Journal Pharmazie Section Abstract Doc Link 18972836 Disease Relevance 0.17 Pain Relevance 0.13
Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica.
Regulation (regulation) of Gene_expression (autoantibodies) of S100Beta associated with neuromyelitis optica
3) Confidence 0.44 Published 2010 Journal Neuroimmunomodulation Section Title Doc Link 20134196 Disease Relevance 1.50 Pain Relevance 0.23
The results of previous studies comparing the serum S100B levels of depressive patients and normal controls showed that depressive patients had higher serum S100B levels than normal controls.17,19,20,35 However, there was no difference in the serum S100B levels of depressive patients and normal controls observed in the present study.
Neg (no) Regulation (difference) of Gene_expression (levels) of S100B associated with depression
4) Confidence 0.40 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.56 Pain Relevance 0.17
Our results show that extracranial sources of S100B do not significantly affect serum levels.
Neg (not) Regulation (affect) of Gene_expression (sources) of S100B
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.29 Pain Relevance 0
Overall, the results of the present study indicate that the S100B levels of the depressive patients did not differ significantly from those of the normal controls.
Neg (not) Regulation (differ) of Gene_expression (levels) of S100B associated with depression
6) Confidence 0.35 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.95 Pain Relevance 0.31
Our attempt to control the increased levels of S100B caused by contamination from the surgical field did not yield different results.
Regulation (control) of Gene_expression (levels) of S100B
7) Confidence 0.27 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC544890 Disease Relevance 0.16 Pain Relevance 0
When this blood is retransfused either directly by cardiotomy suction or later in the course by autotransfusion during the postoperative care, the systemic levels of S100B are affected.
Regulation (affected) of Gene_expression (levels) of S100B in blood
8) Confidence 0.27 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.06 Pain Relevance 0
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Regulation (Effect) of Gene_expression (levels) of S-100B associated with stress and sepsis
9) Confidence 0.16 Published 2005 Journal Clin. Chem. Lab. Med. Section Title Doc Link 15843228 Disease Relevance 1.05 Pain Relevance 0.13
Ca2+-regulated S100 proteins
Regulation (regulated) of Gene_expression (proteins) of S100
10) Confidence 0.15 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Aliquots of the Total, S100 and P100 protein fractions (50 ?
Regulation (Aliquots) of Gene_expression (fractions) of S100
11) Confidence 0.12 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0.08 Pain Relevance 0.03
These neurons show a characteristic topography and vary in S100 expression probably due to their function and maturation.
Regulation (vary) of Gene_expression (expression) of S100 in neurons
12) Confidence 0.05 Published 1995 Journal Neuroscience Section Abstract Doc Link 7675218 Disease Relevance 0 Pain Relevance 0.10
The aim of the study was to compare changes in SEP and serum levels of S-100 beta protein and neuron-specific enolase (NSE) with perioperative clinical neurological deficits in patients undergoing regional anaesthesia (RA).
Regulation (changes) of Gene_expression (levels) of S-100 beta in neuron associated with rheumatoid arthritis
13) Confidence 0.04 Published 2007 Journal Zentralbl Chir Section Abstract Doc Link 17610185 Disease Relevance 0.19 Pain Relevance 0.07

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