INT51066

Context Info Confidence 0.48 First Reported 1995 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 24 Total Number 24 Disease Relevance 13.50 Pain Relevance 0.97

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B) cytoplasm (S100B)

Anatomy Link Frequency smooth muscle 2 Langerhans cell 2 leukocyte 1 neuron 1 myeloid cells 1 S100B (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 69 94.24 Neuritis 2 78.08 imagery 21 76.48 fifth nerve 2 75.00 spastic colon 2 75.00 rheumatoid arthritis 1 74.40 cva 2 73.64 Arthritis 21 71.84 Acute pain 1 71.12 Osteoarthritis 1 70.64

Disease Link Frequency Relevance Heat Cancer 233 99.90 Melanoma 39 99.70 Paraganglioma 5 99.00 Chondroblastoma 17 97.56 Carcinoma 38 96.76 Fibroma 150 96.72 Epstein-barr Virus 1 96.32 Lymphatic System Cancer 7 96.28 Sarcoma 33 95.76 Metastasis 89 95.66

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, utilizing a statistic model, an association between S100B levels the first hours after surgery and neuropsychological outcome was found, where the most informative time point seems to be 1 hour after the termination of CPB.

S100B Binding (association) of

1) Confidence 0.48 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.08 Pain Relevance 0

A pH-dependent sustained release tablet was prepared using a combination of Eudragit L100 and Eudragit S100.

S100 Binding (combination) of

2) Confidence 0.47 Published 2009 Journal Drug Dev Ind Pharm Section Abstract Doc Link 19031287 Disease Relevance 0.14 Pain Relevance 0.07

Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).

S100 Binding (binding) of in Langerhans cell associated with cancer

3) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.34 Pain Relevance 0

CP-10 (chemotactic protein of m.w. 10,000) is a member of the S100 superfamily of Ca2+ binding peptides, which has potent chemotactic activity for murine and human myeloid cells.

S100 Binding (member) of in myeloid cells

4) Confidence 0.36 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378879 Disease Relevance 0.76 Pain Relevance 0.19

Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).

S100 Binding (interactions) of in Langerhans cell associated with cancer

5) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.33 Pain Relevance 0

The cases were evaluated for histologic features and, when material was available, by immunostaining with 7 antibodies: keratin (AE1/AE3), OCT4, placental alkaline phosphatase, alpha-fetoprotein (AFP), CD117, CD30, and S100.

S100 Binding (immunostaining) of

6) Confidence 0.36 Published 2009 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 19461507 Disease Relevance 0.97 Pain Relevance 0.07

Based on its variable immunostaining for smooth muscle actin (SMA) and S-100, some investigators have suggested that they are related to chondroblastoma, but CMF is thought to be far less aggressive and considerably different histologically [5,7,9,12,26-28].

S-100 Binding (immunostaining) of in smooth muscle associated with fibroma and chondroblastoma

7) Confidence 0.36 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2203974 Disease Relevance 1.41 Pain Relevance 0

The clinical tests all measure total S100B, regardless of it monomeric or dimeric state, nor do they consider whether S100B is bound to S100B or S100A1.

S100B Spec (whether) Binding (bound) of

8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.13 Pain Relevance 0

The resected tumor was negative for S-100.

S-100 Binding (negative) of associated with cancer

9) Confidence 0.35 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092435 Disease Relevance 1.57 Pain Relevance 0.05

As previously noted in the literature, the cells can be positive for actin but unlike conventional chondroid neoplasms can be negative for S-100.

S-100 Binding (negative) of associated with cancer

10) Confidence 0.35 Published 2007 Journal Diagn Pathol Section Abstract Doc Link PMC2203974 Disease Relevance 0.64 Pain Relevance 0

It showed immunopositivity for leukocyte common antigen (LCA) and immunonegativity for S-100 and lysozyme.

S-100 Binding (immunonegativity) of in leukocyte

11) Confidence 0.35 Published 2006 Journal J. Neurooncol. Section Abstract Doc Link 16132497 Disease Relevance 0.86 Pain Relevance 0.37

S100B assay

S100B Binding (assay) of

12) Confidence 0.33 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0 Pain Relevance 0

Immunohistochemistry showed strong and diffuse positivity for synaptophysin, chromogranin (Figure 1c), cytokeratin (Figure 1d) Bcl-2 protein and neuron-specific enolase (NSE) but negativity for S100, desmin and epithelial membrane antigen (EMA).

S100 Neg (negativity) Binding (negativity) of in neuron

13) Confidence 0.28 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.15 Pain Relevance 0

Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.

S100 Binding (negative) of

14) Confidence 0.28 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.76 Pain Relevance 0.07

Immunohistochemistry showed strong and diffuse positive staining for neuroendocrine markers (NSE, chromogranin, synaptophysin) and CAM 5.2 but was negative for EMA, S100 and HMB45.

S100 Binding (negative) of

15) Confidence 0.28 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.28 Pain Relevance 0

Thus, a broader panel of immuno-markers may be useful in distinguishing between metastases of malignant melanoma and other metastatic malignancies when the lesion is morphologically undifferentiated; Gupta et al. [15], in fact, reported four cases of morphologically undifferentiated melanoma that showed a positivity for HMB45 (two cases), S100 (one case), vimentin (three cases), NKI/C3 (two cases), NKI/Bteb (one case) and CK (three cases).

S100 Binding (positivity) of associated with melanoma, carcinoma and metastasis

16) Confidence 0.23 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.35 Pain Relevance 0

Determination of specific interactions of the S100 complex with flavocytochrome b558 by atomic force microscopy [157] has been confirmed later by the same group using different experimental systems.

S100 Binding (interactions) of

17) Confidence 0.16 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

However, the transition of cytochrome b558 to an activated state appears to be a result of the binding of the S100 complex.

S100 Binding (binding) of

18) Confidence 0.16 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

This controversy about the site of S100 complex interaction could be explained by the use of different neutrophil model systems and different methods to investigate protein interactions.

S100 Binding (interaction) of in neutrophil

19) Confidence 0.16 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

Preincubation of S100A8/S100A9 in the absence of Ca2+ led to an interaction with flavocytochrome b558 but not to a conformational change, supporting the fact that Ca2+, through S100 binding, is required for NADPH oxidase activity [157].

S100 Binding (binding) of

20) Confidence 0.16 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

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