INT51072

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.84
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr3a) cytoplasm (Htr3a)
Anatomy Link Frequency
nucleus accumbens 2
nucleus 2
cortex 2
Htr3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Antiemetics 1 100.00 Very High Very High Very High
fluoxetine 19 99.98 Very High Very High Very High
Cholecystokinin 12 99.96 Very High Very High Very High
allodynia 6 99.52 Very High Very High Very High
agonist 22 98.80 Very High Very High Very High
Nucleus accumbens 1 98.64 Very High Very High Very High
Desipramine 4 94.36 High High
antagonist 15 93.52 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 5 100.00 Very High Very High Very High
Vomiting 1 100.00 Very High Very High Very High
Hyperglycemia 4 99.96 Very High Very High Very High
Neuropathic Pain 6 99.52 Very High Very High Very High
Anxiety Disorder 3 94.68 High High
Hypertension 35 89.84 High High
Schizophrenia 1 76.20 Quite High
Urological Neuroanatomy 1 74.40 Quite High
Headache 1 50.00 Quite Low
Nociception 1 40.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that selective serotonin reuptake blockers increase extracellular dopamine in the prefrontal cortex by stimulating local 5-HT3 receptors.
Positive_regulation (increase) of Positive_regulation (stimulating) of 5-HT3 in cortex associated with dopamine and serotonin
1) Confidence 0.49 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7675944 Disease Relevance 0 Pain Relevance 0.89
We have previously demonstrated that the pharmacological stimulation of central 5-HT3 receptors, the target for several therapeutic agents used as antiemetics in the course of chemotherapy, induces hyperglycemia.
Positive_regulation (induces) of Positive_regulation (stimulation) of 5-HT3 associated with hyperglycemia and antiemetics
2) Confidence 0.49 Published 2004 Journal Neuropeptides Section Abstract Doc Link 15223272 Disease Relevance 0.36 Pain Relevance 0.36
Previous studies have shown that the activation of 5-HT3 receptors in the nucleus tractus solitarii (NTS) increases the baseline mean arterial pressure (MAP).
Positive_regulation (increases) of Positive_regulation (activation) of 5-HT3 in nucleus
3) Confidence 0.49 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144032 Disease Relevance 0 Pain Relevance 0.36
These data suggest that 5-HT4 receptor activation enhances the ability of 5-HT3 receptor activation to induce intestinal allodynia.
Positive_regulation (induce) of Positive_regulation (activation) of 5-HT3 associated with allodynia
4) Confidence 0.49 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10471214 Disease Relevance 0.25 Pain Relevance 0.29
These data suggest that 5-HT4 receptor activation enhances the ability of 5-HT3 receptor activation to induce intestinal allodynia.
Positive_regulation (enhances) of Positive_regulation (activation) of 5-HT3 associated with allodynia
5) Confidence 0.49 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10471214 Disease Relevance 0.25 Pain Relevance 0.29
The obtained results indicate that fluoxetine increases the MK-801-induced locomotor hyperactivity via activation of 5-HT3 receptors and, to a lesser degree, 5-HT2 ones.
Positive_regulation (increases) of Positive_regulation (activation) of 5-HT3 associated with attention deficit hyperactivity disorder and fluoxetine
6) Confidence 0.49 Published 1996 Journal J Neural Transm Section Abstract Doc Link 9026367 Disease Relevance 0.38 Pain Relevance 0.75
Activation of 5-HT3 receptors was found to increase CCK release from rat cortical or nucleus accumbens synaptosomes.
Positive_regulation (increase) of Positive_regulation (Activation) of 5-HT3 in nucleus accumbens associated with nucleus accumbens and cholecystokinin
7) Confidence 0.49 Published 1993 Journal Neurochem. Int. Section Abstract Doc Link 8513278 Disease Relevance 0.43 Pain Relevance 1.08
In vivo microdialysis was used to investigate the mechanism behind the increase in extracellular dopamine (DA) induced by increase in extracellular serotonin (5-HT) level and 5-HT1 and 5-HT2 receptor activation.
Positive_regulation (increase) of Positive_regulation (activation) of 5-HT2 receptor associated with dopamine and serotonin
8) Confidence 0.33 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9632315 Disease Relevance 0 Pain Relevance 0.39
These findings suggest that upregulation of the 5-HT2B receptor proteins is not absolutely required for this receptor to mediate agonist-induced contraction.


Neg (not) Positive_regulation (required) of Positive_regulation (upregulation) of 5-HT2B receptor associated with agonist
9) Confidence 0.18 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC201025 Disease Relevance 0.17 Pain Relevance 0.13
CONCLUSION: Our results suggest that activation of the 5-HT2A receptor leads to an enhancement of NO production in trigeminovascular pathway.
Positive_regulation (leads) of Positive_regulation (activation) of 5-HT2A receptor
10) Confidence 0.16 Published 2002 Journal Headache Section Body Doc Link 12482207 Disease Relevance 0 Pain Relevance 0

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