INT51083

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 8.24
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Adc)
Anatomy Link Frequency
brain 4
smooth muscle 2
endothelial cells 1
astrocyte 1
Median nerve 1
Adc (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 42 99.64 Very High Very High Very High
addiction 1 99.12 Very High Very High Very High
cva 84 99.08 Very High Very High Very High
Clonidine 10 98.12 Very High Very High Very High
imagery 303 90.20 High High
Central nervous system 18 76.24 Quite High
medulla 2 69.64 Quite High
midbrain 1 68.84 Quite High
Hippocampus 12 54.08 Quite High
Catecholamine 2 44.68 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 288 99.64 Very High Very High Very High
Cv Unclassified Under Development 26 99.64 Very High Very High Very High
Injury 26 99.12 Very High Very High Very High
Cerebral Infarction 54 99.08 Very High Very High Very High
Intracranial Hypertension 42 98.80 Very High Very High Very High
Edema 120 98.44 Very High Very High Very High
Hydrocephalus 258 97.92 Very High Very High Very High
Leukoencephalopathies 2 97.92 Very High Very High Very High
Dementia 32 97.88 Very High Very High Very High
Stroke 70 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Median nerve CSA, ADC, and FA were analyzed at standardized anatomic levels.
Spec (analyzed) Gene_expression (analyzed) of ADC in Median nerve
1) Confidence 0.53 Published 2009 Journal Skeletal Radiol. Section Body Doc Link 19132371 Disease Relevance 0 Pain Relevance 0
The ADC maps were produced by use of ADC values > or = 3 SD and > or = 10 SD above the mean value of normal WM.
Gene_expression (produced) of ADC
2) Confidence 0.52 Published 2001 Journal AJNR Am J Neuroradiol Section Body Doc Link 11559490 Disease Relevance 0 Pain Relevance 0
Studies have shown a correlation between ADC severity and CSF HIV-1 RNA and ?
Gene_expression (severity) of ADC associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.50 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.63 Pain Relevance 0
These figures therefore suggest that there should have been more ADC progressions in the study participants if HAART had no effect on dementia.
Gene_expression (progressions) of ADC associated with dementia
4) Confidence 0.50 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.19 Pain Relevance 0
However, the fact that both the SBG and ABC groups improved at week 12 of the study (that is, after at least 5 mo on HAART) and that there were only two ADC progressions (both in the SBG group) strongly suggest that HAART does have efficacy in ADC leading to a lengthening of the time window.
Gene_expression (progressions) of ADC
5) Confidence 0.50 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.20 Pain Relevance 0
For an antiretroviral therapy (ART) to be effective in ADC, theoretically it should have potent antiviral activity, ability to penetrate the brain at efficacious concentrations, and activity in macrophages and microglia, the primary targets of HIV infection within the brain.
Gene_expression (effective) of ADC in brain associated with acquired immune deficiency syndrome or hiv infection and infection
6) Confidence 0.50 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.26 Pain Relevance 0
In addition, CBF and ADC values did not differ between C57Bl/6 and Sv/129 mice at any time point or region of interest.
Gene_expression (values) of ADC
7) Confidence 0.49 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2847985 Disease Relevance 0.65 Pain Relevance 0.24
Similarly, ADC values in the same ROIs showed no statistical differences between group means.
Gene_expression (values) of ADC
8) Confidence 0.49 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2847985 Disease Relevance 0.55 Pain Relevance 0
We investigated whether vascular smooth muscle and endothelial cells express imidazoline (I-) receptors, their endogenous ligand agmatine and/or its biosynthetic enzyme arginine decarboxylase (ADC), and if I-receptors regulate smooth muscle proliferation.
Spec (whether) Gene_expression (express) of arginine decarboxylase in smooth muscle
9) Confidence 0.25 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786560 Disease Relevance 0 Pain Relevance 0.08
The two most commonly used indices of water diffusion in tissue are the magnitude, expressed as the apparent diffusion coefficient (ADC) and the directional dependence of diffusion (diffusion anisotropy [12]) , often expressed as the fractional anisotropy (FA) [13].
Gene_expression (expressed) of ADC associated with addiction
10) Confidence 0.25 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.23 Pain Relevance 0.21
We investigated whether vascular smooth muscle and endothelial cells express imidazoline (I-) receptors, their endogenous ligand agmatine and/or its biosynthetic enzyme arginine decarboxylase (ADC), and if I-receptors regulate smooth muscle proliferation.
Gene_expression (biosynthetic) of arginine decarboxylase in endothelial cells
11) Confidence 0.22 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786560 Disease Relevance 0 Pain Relevance 0.08
Interestingly, however, we observed decreased ADC values in a periventricular rim in the parietal region in two patients.
Gene_expression (values) of ADC in parietal
12) Confidence 0.11 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.34 Pain Relevance 0.04
We investigated whether vascular smooth muscle and endothelial cells express imidazoline (I-) receptors, their endogenous ligand agmatine and/or its biosynthetic enzyme arginine decarboxylase (ADC), and if I-receptors regulate smooth muscle proliferation.
Gene_expression (biosynthetic) of arginine decarboxylase in smooth muscle
13) Confidence 0.07 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786560 Disease Relevance 0 Pain Relevance 0.08
Linear regression did not propose direct linear correlation of ADC values and AQP4 expression in the periventricular region, in opposition to data presented in one other study [17].
Gene_expression (expression) of ADC
14) Confidence 0.07 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.93 Pain Relevance 0.29
We consider that changes in ADC values and AQP4 represent phases of ICP changes following hydrocephalus development.
Gene_expression (values) of ADC associated with hydrocephalus and cva
15) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.99 Pain Relevance 0.29
At two weeks, increased abundance of AQP4 expressed in astrocyte processes of the periventricular region was found, together with significant elevated ADC values.
Gene_expression (values) of ADC in astrocyte
16) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.78 Pain Relevance 0.27
In the same study it was shown that cell injury following global ischemia causes decreased ADC values in both extra- and intracellular compartments [54].
Gene_expression (values) of ADC associated with ischemia and injury
17) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.94 Pain Relevance 0.17
No significant linear correlation between periventricular AQP4 expression and ADC value was found (Figure 9).


Gene_expression (expression) of ADC
18) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.45 Pain Relevance 0.04
The missing correlation between AQP4 expression and ADC-values indicate that other factors such as co-transporters may play a major role in brain water transport.


Gene_expression (expression) of ADC in brain
19) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.87 Pain Relevance 0.13
It and its biosynthetic enzyme arginine decarboxylase are present in brain, and agmatine is widely distributed throughout the body.
Gene_expression (present) of arginine decarboxylase in brain
20) Confidence 0.02 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677340 Disease Relevance 0.22 Pain Relevance 0.21

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