INT51084

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Context Info
Confidence 0.30
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.25
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
DRG 3
plasma 1
longitudinal muscle 1
neurons 1
skin 1
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 5 100.00 Very High Very High Very High
isoflurane 2 99.62 Very High Very High Very High
Migraine 3 99.48 Very High Very High Very High
Sciatic nerve 2 99.40 Very High Very High Very High
chemokine 50 99.02 Very High Very High Very High
Clonidine 7 98.80 Very High Very High Very High
dorsal root ganglion 7 97.72 Very High Very High Very High
tail-flick 12 95.16 Very High Very High Very High
Enkephalin 1 88.16 High High
Peripheral nerve injury 5 87.68 High High
Disease Link Frequency Relevance Heat
Migraine With Aura 6 99.48 Very High Very High Very High
Heart Rate Under Development 1 98.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 166 97.36 Very High Very High Very High
Ganglion Cysts 12 97.24 Very High Very High Very High
Insulin Resistance 6 95.08 Very High Very High Very High
Nervous System Injury 9 92.36 High High
Attention Deficit Hyperactivity Disorder 93 91.84 High High
Infection 68 83.88 Quite High
Pain 2 82.00 Quite High
Neurodegenerative Disease 56 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkable side-by-side differences in the number of Fos-IR neurons were recognized at 1 to 4 h following the experimental tooth movement.
Fos-IR Binding (recognized) of in tooth
1) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0 Pain Relevance 0.24
After total or partial sciatic nerve transection, or spinal nerve ligation, VR1-immunoreactivity (IR) was significantly reduced in the somata of all damaged dorsal root ganglion (DRG) neuronal profiles, compared to controls.
IR Binding (ligation) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, spinal nerve ligature and sciatic nerve
2) Confidence 0.25 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422451 Disease Relevance 0.97 Pain Relevance 0.92
Another subpopulation containing GRP-IR, but not VIP-IR, projects mainly to the myenteric plexus itself and the external muscle layers, particularly the longitudinal muscle.
GRP-IR Binding (projects) of in longitudinal muscle
3) Confidence 0.23 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8797157 Disease Relevance 0 Pain Relevance 0.09
A novel visible four-channel fluorescence technique revealed a unique population of P2X2/3-IR neurons that lacked GS-I-B(4)-binding but expressed NF-IR.
NF-IR Binding (binding) of in neurons
4) Confidence 0.20 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11118807 Disease Relevance 0.08 Pain Relevance 0.12
Ir-CDS, also of unknown structure, is a material(s) that binds to antibodies raised against clonidine, PAC, or idazoxan.
Ir-CDS Binding (binds) of associated with heart rate under development and clonidine
5) Confidence 0.16 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677340 Disease Relevance 0.23 Pain Relevance 0.62
We performed the first replication study for the reported association of the insulin receptor gene (INSR) with migraine with aura (MA).
insulin receptor gene Binding (association) of associated with migraine with aura and migraine
6) Confidence 0.15 Published 2008 Journal Genomics Section Abstract Doc Link 18455362 Disease Relevance 0.43 Pain Relevance 0.17
Only 7% of the Australian children, 3–17 years old, received a combination of MPH IR and ER in 2004 (Preen et al. 2007).
MPH IR Binding (combination) of
7) Confidence 0.06 Published 2010 Journal Atten Defic Hyperact Disord Section Body Doc Link PMC3000908 Disease Relevance 0.63 Pain Relevance 0
The endocytosis of hepatic IR is linked to the endocytosis of the glucose transporter 2 from the hepatocyte plasma membrane, and studies suggest that the 2 plasma membrane-bound proteins are complexed noncovalently to function and translocate as a unit after insulin binding to the hepatic IR.
insulin Binding (binding) of in plasma
8) Confidence 0.04 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
One percent isoflurane inhalation and an IR20 heat intensity (which was 161.5 mW/cm(2) and resulted in a skin temperature of 65 degrees C after 10 s of radiation) provided reliable TF latencies on repeated TF testing.
IR20 Binding (intensity) of in skin associated with tail-flick and isoflurane
9) Confidence 0.03 Published 2008 Journal Exp. Anim. Section Abstract Doc Link 18256520 Disease Relevance 0.06 Pain Relevance 0.89
Some of these medications can bind the insulin receptor kinase domain and inhibit downstream phosphorylation of targets, or reduce voltage-gated K+ channels and other anion currents (Neye et al. 2006), which are known to affect glucose sensitivity and insulin response signaling (Xu et al. 2004; Desir 2005; Li et al. 2006; Tschritter et al. 2006).
insulin Binding (bind) of
10) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.48 Pain Relevance 0.09
Following L5 spinal nerve ligation, the number of TrkA-IR neurons in the L5 DRG slowly declined, reducing by 25% at 1 week and 35% at 3 weeks postoperation (PO).
TrkA-IR Binding (ligation) of in DRG associated with spinal nerve ligature
11) Confidence 0.03 Published 1999 Journal Exp Brain Res Section Abstract Doc Link 10442405 Disease Relevance 0.30 Pain Relevance 0.48
Following L5 spinal nerve ligation, the number of TrkA-IR neurons in the L5 DRG slowly declined, reducing by 25% at 1 week and 35% at 3 weeks postoperation (PO).
TrkA-IR Binding (ligation) of in DRG associated with spinal nerve ligature
12) Confidence 0.03 Published 1999 Journal Exp Brain Res Section Abstract Doc Link 10442405 Disease Relevance 0.30 Pain Relevance 0.48
Mechanisms of metabolic disruption in HIV-infected patients remain unclear, but it is hypothesized that peripheral chemokine signaling is at least partially involved in the alteration of insulin and glucose homeostasis (Hardy et al. 2001; Carper et al. 2008).
insulin Binding (alteration) of associated with chemokine and acquired immune deficiency syndrome or hiv infection
13) Confidence 0.02 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.78 Pain Relevance 0.12

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