INT51089

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Context Info
Confidence 0.24
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.18
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRMT1) methyltransferase activity (PRMT1) nucleus (PRMT1)
cytoplasm (PRMT1)
Anatomy Link Frequency
hypothalamus 1
liver 1
PRMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 3 100.00 Very High Very High Very High
Nucleus accumbens 1 99.68 Very High Very High Very High
Central grey 1 97.52 Very High Very High Very High
alcohol 8 95.68 Very High Very High Very High
Clonidine 4 89.80 High High
Enkephalin 1 85.72 High High
Opioid 2 84.12 Quite High
Central nervous system 1 82.72 Quite High
fibrosis 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 97.52 Very High Very High Very High
Targeted Disruption 4 95.24 Very High Very High Very High
Hepatitis C Virus Infection 64 94.80 High High
Osteogenic Sarcomas 4 86.04 High High
Aggression 2 57.76 Quite High
Chronic Hepatitis 8 50.00 Quite Low
Chronic Hepatitis C 2 50.00 Quite Low
Hepatocellular Cancer 6 49.12 Quite Low
Infection 6 45.48 Quite Low
Cirrhosis 6 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An important consequence of the increased amount of PP2Ac is the inhibition of protein arginine methyltransferase 1 (PRMT1) [8], [9].
Negative_regulation (inhibition) of PRMT1
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.47 Pain Relevance 0
An important consequence of the increased amount of PP2Ac is the inhibition of protein arginine methyltransferase 1 (PRMT1) [8], [9].
Negative_regulation (inhibition) of arginine methyltransferase 1
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.46 Pain Relevance 0
A good correlation exists between the affinities of various imidazoline/guanidine type ligands for IR-I2 in both human placenta and rat liver membranes which can be accurately determined because both tissues lack IR-I1 and alpha 2-adrenergic receptors.
Negative_regulation (lack) of IR-I1 in liver
3) Confidence 0.11 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677341 Disease Relevance 0 Pain Relevance 0.27
These animals had a decreased activity of dynorphin B-ir in the nucleus accumbens, decreased levels of MEAP-ir in the periaqueductal gray (PAG) and higher levels of MEAP-ir in the hypothalamus compared to controls.
Negative_regulation (decreased) of B-ir in hypothalamus associated with nucleus accumbens, dynorphin, urological neuroanatomy and central grey
4) Confidence 0.04 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11124391 Disease Relevance 0.25 Pain Relevance 0.71

General Comments

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