INT51099

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.97
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nisch) plasma membrane (Nisch) cytoplasm (Nisch)
Anatomy Link Frequency
brainstem 2
blood 1
medulla 1
heart 1
Nisch (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 26 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Clonidine 23 97.96 Very High Very High Very High
Rostral ventrolateral medulla 3 93.12 High High
Catecholamine 3 88.44 High High
antidepressant 9 85.40 High High
Potency 1 75.40 Quite High
cerebral cortex 1 67.84 Quite High
depression 1 47.08 Quite Low
agonist 1 29.56 Quite Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 7 100.00 Very High Very High Very High
Hypertension 3 92.40 High High
Hypotension 9 91.16 High High
Pressure And Volume Under Development 1 78.88 Quite High
Cardiovascular Disorder Under Development 1 47.08 Quite Low
Miosis 1 46.00 Quite Low
Glaucoma 1 31.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of IR1 sites was dose-dependent (minimal effective dose of i.p.
Negative_regulation (Downregulation) of IR1
1) Confidence 0.43 Published 1997 Journal Life Sci. Section Abstract Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.44
Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem.
Negative_regulation (downregulates) of IR1 in brainstem associated with medulla
2) Confidence 0.38 Published 1997 Journal Life Sci. Section Title Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.36
However, IMI induced a decrease in the density (Bmax measured under NE mask) of brainstem IR1 sites, with no change in KD.
Negative_regulation (decrease) of IR1 in brainstem associated with medulla
3) Confidence 0.37 Published 1997 Journal Life Sci. Section Abstract Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.45
The effects of selective blockade of alpha2- or I1 receptor by 2-methoxyidazoxan and efaroxan, respectively, on the blood pressure and heart rate responses to clonidine and subsequent ethanol administration were evaluated in conscious spontaneously hypertensive rats.
Negative_regulation (blockade) of I1 receptor in heart associated with hypertension and clonidine
4) Confidence 0.35 Published 2001 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11486246 Disease Relevance 0.40 Pain Relevance 0.51
However, unilateral microinjection of idazoxan (a mixed antagonist of imidazoline receptor and alpha2-adrenoceptor, 2 nmol/50 nl) into the caudal ventrolateral medulla significantly (P<0.01) decreased mean arterial pressure, heart rate, and the discharge of the rostral ventrolateral medulla presympathetic neurons, and completely abolished the pressor effect of clonidine.
Negative_regulation (antagonist) of imidazoline receptor in medulla associated with medulla, rostral ventrolateral medulla, antagonist and clonidine
5) Confidence 0.17 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 12827019 Disease Relevance 0.08 Pain Relevance 1.08
Taken together, these results indicate that brimonidine stimulates an ocular alpha-2 adrenoceptor to decrease IOP in the rabbit and a CNS imidazoline receptor to decrease IOP, blood pressure, and heart rate in the cynomolgus monkey.
Negative_regulation (decrease) of imidazoline receptor in blood associated with ocular hypertension
6) Confidence 0.01 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677389 Disease Relevance 0.49 Pain Relevance 0.10

General Comments

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