INT511

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.58
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IARS) nucleolus (IARS) nucleus (IARS)
ligase activity (IARS) cytoplasm (IARS)
Anatomy Link Frequency
Plasma 1
brain 1
IARS (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 12 88.84 High High
Chronic pancreatitis 1 88.40 High High
Neuropeptide 1 73.36 Quite High
cocaine 1 69.24 Quite High
headache 5 57.20 Quite High
Infliximab 34 50.00 Quite Low
rheumatoid arthritis 30 46.56 Quite Low
cytokine 1 43.40 Quite Low
methotrexate 21 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 1 100.00 Very High Very High Very High
Malaria 129 94.60 High High
Obesity 28 93.56 High High
Mycobacterial Infection 25 91.28 High High
Cancer 16 88.80 High High
Pancreatitis 1 88.40 High High
Allergic Dermatitis 3 86.56 High High
Viral Meningitis 1 85.60 High High
Body Weight 8 81.28 Quite High
Meningeal Tuberculosis 1 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma immunoreactive secretin (IRS) increased from 3.0 +/- 0.8 pmol/l (mean +/- S.E.M.) to 9.8 +/- 0.5 pmol/l (p less than 0.01) in the duodenectomized patients.
Positive_regulation (increased) of IRS in Plasma
1) Confidence 0.45 Published 1979 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 43589 Disease Relevance 0.18 Pain Relevance 0.09
It was observed that the caregivers in both groups of villages had a poor perception of IRS in contrast to another study in south-western Ethiopia showing that the majority of the community knew the reason for house spraying [42].
Positive_regulation (perception) of IRS
2) Confidence 0.43 Published 2010 Journal Malar J Section Body Doc Link PMC2829593 Disease Relevance 0.73 Pain Relevance 0
Furthermore, mRNA-levels of eight different aminoacyl-tRNA synthetases (CARS, EPRS, GARS, IARS, MARS, SARS, WARS, YARS) were upregulated.


Positive_regulation (upregulated) of IARS associated with severe acute respiratory syndrome
3) Confidence 0.36 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.29 Pain Relevance 0
Overall, the highest incidence of IRs and the highest incidence of IRs leading to discontinuation occurred during the first 26 weeks (Figure 2c).
Positive_regulation (incidence) of IRs
4) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911915 Disease Relevance 1.60 Pain Relevance 0.10
Conversely, the insulin-controlled internalization of IR has been shown to depend on IR autophosphorylation [13],[16],[17], but to be independent of downstream activation of IRS or phosphatidylinositol-3 kinase [17].
Positive_regulation (activation) of IRS
5) Confidence 0.20 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.23 Pain Relevance 0
A hundred IRs with 12 single reflections each of random relative level were generated (750 samples, 1.86 ms).
Positive_regulation (generated) of IRs
6) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847841 Disease Relevance 0.08 Pain Relevance 0
Obese individuals who have recently lost substantial amounts of weight became insulinresistant when put on a short-term hypercaloric diet, while lean individuals remained sensitive to insulin under identical circumstances.50 This phenomenon is explained, at least to some extent, by the ability of nutrient excess to block the activation of IRS/ PI 3-kinase signal transduction.51 Indeed, blunting of signal transduction by macronutrients has been observed in peripheral tissues as well as in brain tissue.29,52,53 Lastly, cumulating data have indicated that free fatty acids (FFAs) and glucose are each capable of increasing hepatic sensitivity to insulin and of reducing hepatic glucose production.
Positive_regulation (activation) of IRS in brain associated with obesity
7) Confidence 0.05 Published 2007 Journal Obes Surg Section Body Doc Link PMC2798024 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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