INT51106

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.76
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PPP1R1A) carbohydrate metabolic process (PPP1R1A)
Anatomy Link Frequency
erythrocytes 1
extracellular matrix 1
knee 1
PPP1R1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
mu opioid receptor 1 99.64 Very High Very High Very High
cINOD 3 99.58 Very High Very High Very High
metalloproteinase 3 99.16 Very High Very High Very High
agonist 6 98.36 Very High Very High Very High
Osteoarthritis 1 96.96 Very High Very High Very High
cytokine 13 96.76 Very High Very High Very High
Clonidine 4 94.80 High High
Catecholamine 1 93.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 31 99.30 Very High Very High Very High
Adhesions 16 98.44 Very High Very High Very High
Knee Osteoarthritis 1 97.16 Very High Very High Very High
Cancer 3 95.88 Very High Very High Very High
Necrosis 4 95.64 Very High Very High Very High
Diabetes Mellitus 83 95.36 Very High Very High Very High
Metabolic Syndrome 15 94.32 High High
Apoptosis 89 93.04 High High
Hemorrhage 1 78.56 Quite High
Injury 5 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I1 receptors were barely detected in the dog, rat, and mouse and only further examined by competition binding experiments in calf, rabbit, and human.
Gene_expression (detected) of I1
1) Confidence 0.67 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415909 Disease Relevance 0 Pain Relevance 0.31
Binding studies with [3H]idazoxan and [3H]p-aminoclonidine did not reveal the expression of I1 and I2 binding sites in erythrocytes.
Gene_expression (expression) of I1 in erythrocytes
2) Confidence 0.60 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8925867 Disease Relevance 0 Pain Relevance 0.09
An equivalent fusion protein between the human mu opioid receptor-1 and G(i1)alpha produced a similar D-ala(2),D-leu(5) enkephalin-induced GTP turnover number as the delta opioid receptor-G(i1)alpha fusion construct, consistent with agonist occupation of these two opioid receptor subtypes being equally efficiently coupled to activation of G(i1)alpha.
Gene_expression (produced) of i1 associated with agonist, mu opioid receptor, opioid receptor and enkephalin
3) Confidence 0.33 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259498 Disease Relevance 0.13 Pain Relevance 0.71
While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidine analog that may be an endogenous imidazoline receptor ligand, can interact with both I1 and I2 imidazoline receptors as well as alpha 2-adrenoceptors, although, interestingly, other guanidines such as guanabenz are highly selective for alpha 2-adrenoceptors versus I1 receptors.
Gene_expression (selective) of I1 associated with catecholamine
4) Confidence 0.32 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677390 Disease Relevance 0 Pain Relevance 0.28
OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.
Spec (examine) Gene_expression (expression) of PA inhibitor-1 in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis
5) Confidence 0.15 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47
To maintain vascular homeostasis, the endothelium produces components of the extracellular matrix such as collagen and a variety of regulatory chemical mediators, including nitric oxide (NO), prostanoids (prostacycline), endothelin-1 (ET-1), angiotensin II (ANG-II), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF), adhesion molecules (VCAM, LAM, ICAM), and cytokines, among them Tumor Necrosis Factor ?
Gene_expression (produces) of inhibitor-1 in extracellular matrix associated with necrosis, cancer, adhesions and cytokine
6) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.29 Pain Relevance 0.12

General Comments

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